Subregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study

Faber, Benjamin G; Bredbenner, Todd L.; Baird, Denis; Gregory, Jennifer S.; Saunders, Fiona; Giuraniuc, Claudio; Aspden, Richard M.; Lane, Nancy E.; Orwoll, Eric S.; Tobias, Jonathan H

doi:10.1016/j.joca.2020.04.011

Cited by 17 publications

(16 citation statements)

References 49 publications

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“…The associations between hip OA and both cam morphology and acetabular dysplasia have already been proven in other studies that used traditional measurements, such as the alpha angle and the CEA 7,8,10,28e35 . Two cross-sectional studies that used SSM also found associations between cam morphology and the presence of hip OA 36,37 . These studies were not included in our systematic review due to their cross-sectional design.…”

Section: Discussionmentioning

confidence: 97%

Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review

Buuren

Arden

Bierma-Zeinstra

et al. 2021

Osteoarthritis and Cartilage

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Section: Discussionmentioning

confidence: 97%

Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review

Buuren

Arden

Bierma-Zeinstra

et al. 2021

Osteoarthritis and Cartilage

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“…(6) SSM has identified relationships between HOA and a range of shape changes besides cam and pincer-type morphology, including femoral head size, femoral neck (FN) width, and lesser and greater trochanter size. (4,7) A possible explanation for the heterogeneous findings from different studies is the varying definitions used for HOA, including radiographic HOA (rHOA), symptomatic rHOA, and end-stage disease as reflected by THR.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning–Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank

Frysz

Faber

Ebsim

et al. 2020

Journal of Bone and Mineral Research

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The contribution of shape changes to hip osteoarthritis (HOA) remains unclear, as is the extent to which these vary according to HOA severity. In the present study, we used statistical shape modeling (SSM) to evaluate relationships between hip shape and HOA of different severities using UK Biobank DXA images. We performed a cross-sectional study in individuals with left hip dual-energy X-ray absorptiometry (DXA) scans. Statistical shape modeling (SSM) was used to quantify hip shape. Radiographic HOA (rHOA) was classified using osteophyte size and number and joint space narrowing. HOA outcomes ranged in severity from moderate (grade 2) to severe (grade ≥3) rHOA, hospital-diagnosed HOA, and subsequent total hip replacement (THR). Confounder-adjusted logistic regression between the top 10 hip shape modes (HSMs) and OA outcomes was performed. Further models adjusted for alpha angle (AA) and lateral center-edge angle (LCEA), reflecting acetabular dysplasia and cam morphology, respectively. Composite HSM figures were produced combining HSMs associated with separate OA outcomes. A total of 40,311 individuals were included (mean 63.7 years, 47.8% male), of whom 5.7% had grade 2 rHOA, 1.7% grade ≥3 rHOA, 1.3% hospital-diagnosed HOA, and 0.6% underwent THR. Composite HSM figures for grade 2 rHOA revealed femoral neck widening, increased acetabular coverage, and enlarged lesser and greater trochanters. In contrast, grade ≥3 rHOA, hospital-diagnosed HOA, and THR were suggestive of cam morphology and reduced acetabular coverage. Associations between HSMs depicting cam morphology and reduced acetabular coverage and more severe HOA were attenuated by AA and LCEA adjustment, respectively. Relationships between hip shape and HOA differed according to severity. Notably, cam morphology and acetabular dysplasia were features of severe HOA, but unrelated to moderate disease, suggesting possible prognostic utility.

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“…The same genetic variants associated with hip shape and endochondral bone formation in adults appear to be important in adolescence [17]. Further work using SSM show that lesser trochanter size and cam-type FAI are related to radiographic OA [18].…”

Section: Hip Imaging Studiesmentioning

confidence: 85%

Bone in osteoarthritis: imaging and interventions

Khokhar

Conaghan

2021

Current Opinion in Rheumatology

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Purpose of reviewTo review the recent literature on bone in osteoarthritis (OA), with a focus on imaging and intervention studies Recent findingsMost studies focused on knee OA; hip and hand studies were uncommon. Bone shape studies demonstrated that shape changes precede radiographic OA, predict joint replacement, and have demonstrated high responsiveness. Novel quantitative 3D imaging markers (B-score) have better characterized OA severity, including preradiographic OA status. The addition of computerized tomography-derived 3D metrics has improved the prediction of hip joint replacement when compared to radiographs alone. Recent studies of bisphosphonates for knee OA have reported no benefits on pain or bone marrow lesion (BML) size. A meta-analysis on Vitamin D supplementation in knee OA suggested minimal symptom improvement and no benefits on the structure. Cathepsin K inhibition demonstrated reduction in OA bone change progression, but with no symptom benefit. Studies of injections of bone substitutes into BMLs (subchondroplasty) have generally been small and potential benefits remain unclear. SummarySubchondral bone features are associated with pain, incidence and progression of OA. Recent studies have validated quantitative bone shape as a biomarker for OA trials. Trials of bone-targeted OA therapies have been disappointing although cathepsin K inhibition may slow structural progression.

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Subregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study

Cited by 17 publications

References 49 publications

Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review

Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review

Machine Learning–Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank

Bone in osteoarthritis: imaging and interventions

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