Subsequent Afebrile Seizure in Children Who Have a First Seizure With Fever After 6 Years of Age

Kim, Sunghwan; Lee, Hyun‐Young; Kim, Yeun-Hee

doi:10.1016/j.pediatrneurol.2010.03.009

Cited by 4 publications

(8 citation statements)

References 16 publications

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“…Summarizing the available prognostic data, the percentage of subsequent unprovoked seizures in patients older than 5 years was 13% (4 of 32) 6,10) and in patients older than 6 years was 9% (9 of 94) including our results 12) .…”

Section: Discussionsupporting

confidence: 72%

“…We found, though, no significant variables predictive of subsequent unprovoked seizures in older ages. Other smaller studies also failed to find the risk factors in older patients 11,12) .…”

Section: Discussionmentioning

confidence: 96%

“…Our study revealed that an unprovoked seizure recurred in seven of 79 patients (9%) following a first late-onset febrile seizure. We also reviewed previous studies regarding the prognosis of either first (Table 4) 6,[9][10][11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

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Prognosis in Late-Onset Febrile Seizure

Baek¹,

Hwang²,

Jung-Hye³

et al. 2017

journalofthekoreanchildneurologysociety

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Prognosis in Late-Onset Febrile SeizurePurpose: There is a paucity of evidence about prognosis after a first febrile seizure in older children. We investigated the prognosis and potential risk factors associated with subsequent unprovoked seizures in children who had experienced a first febrile seizure over 6 years of age, which we termed as late-onset febrile seizure. Methods: We included all patients six years or older who presented to the emergency department with a febrile seizure between 2009 and 2015. Clinical data was collected by chart review and parents were contacted for information on seizure progress. We used the Cox proportional-hazards model and Kaplan-Meier analysis for evaluating the risk factors for subsequent unprovoked seizures. Results: Of 247 patients, we excluded 168 children who had a history of epilepsy, unprovoked, or febrile seizure and who were followed-up for period less than six months. Overall, 79 patients were classified as having had a first late-onset febrile seizure. During follow-up of 34.9±25.7(mean±SD) months, unprovoked seizure recurred in 7 of 79 patients (9%). The cumulative probability of seizure recurrence was 4% at 6 months, 6% at 1 year and 9% at 2 years. Clinical variables predictive of subsequent unprovoked seizures were not proved. Conclusion: This is the first multicenter study focusing on prognosis after a lateonset febrile seizure in children six years or older. The percentage of subsequent unprovoked seizure in patients with late-onset febrile seizure was 9% at 2 years of follow-up. Prospective follow-up study with longer duration is warranted.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 96%

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Prognosis in Late-Onset Febrile Seizure

Baek¹,

Hwang²,

Jung-Hye³

et al. 2017

journalofthekoreanchildneurologysociety

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“…"Illness-related seizures" may also be difficult to interpret if there is no fever (Lee and Ong, 2004). The age limits for febrile seizures are said to be 6 months and 5 years, however, some older children will have a seizure with fever but not go on to develop epilepsy (Kim et al, 2010). All epilepsy incidence studies require an inclusive case-finding method (Kotsopoulos et al, 2002).…”

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confidence: 99%

Incidence, prevalence and aetiology of seizures and epilepsy in children

Camfield

2015

Epileptic Disorders

381

209

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Aim. To (1) summarize published, peer‐reviewed literature about the incidence and prevalence of epilepsy in children from developed and developing countries around the world, and (2) discuss problems in defining aetiologies of epilepsy in children, and distinguish between seizures and epilepsy. Methods. Review of selected literature with particular attention to systematic reviews. Results. The incidence of epilepsy in children ranges from 41–187/100,000. Higher incidence is reported from underdeveloped countries, particularly from rural areas. The incidence is consistently reported to be highest in the first year of life and declines to adult levels by the end of the first decade. The prevalence of epilepsy in children is consistently higher than the incidence and ranges from 3.2–5.5/1,000 in developed countries and 3.6–44/1,000 in underdeveloped countries. Prevalence also seems highest in rural areas. The incidence and prevalence of specific seizure types and epilepsy syndromes is less well documented. In population‐based studies, there is a slight, but consistent, predominance of focal seizures compared with generalized seizures. Only about one third of children with epilepsy can be assigned to a specific epilepsy syndrome, as defined by the most recently proposed system for organization of epilepsy syndromes. Conclusions. The incidence and prevalence of epilepsy in children appears to be lower in developed countries and highest in rural areas of underdeveloped countries. The reasons for these trends are not well established. Although focal seizures predominate, the incidence and prevalence of specific epilepsy syndromes is not well documented.

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“…현재까지 비열성 발작을 보이는 위험인자로 발달지연, 복합열경련, 뇌 파 이상, 뇌전증의 가족력 등이 알려져 있다 1,3,4) . 하지만, 6세 이후 열경 련을 보이는 환자에서 비열성 발작을 보이거나 뇌전증으로 진행되는 위 험인자에 대한 연구는 일부에서만 이루어져 왔다 2,5,6,9,13) . 6세…”

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The Prognostic Factors Affecting the Occurrence of Subsequent Unprovoked Seizure in Patients Who Present with Febrile Seizure after 6 Years of Age

Lee¹,

Kim²

2018

Child Neurol

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Purpose: Few reports have described the prognostic factors affecting the occurrence of subsequent unprovoked seizure in patients who present with febrile seizure (FS) after 6 years of age. We investigated the prognostic factors affecting the development of unprovoked seizures after FS among patients from Jeju Island. Methods: We included patients who developed FS after 6 years of age, who presented to our outpatient clinic between January, 2011 and June, 2017. Clinical data were obtained through chart reviews and phone call interviews. We used logistic regression analysis to analyze the risk factors associated with the occurrence of subsequent unprovoked seizure. Results: Of the 895 patients who presented to our hospital due to their febrile seizure, 83 developed FS after 6 years of age. Among them, 3 patients were prescribed antiepileptic drugs before the onset of the unprovoked seizure, and 4 patients developed an unprovoked seizure before 6 years of age. Thus, overall, 76 patients were included in the study. 51 patients developed first FS before 6 years of age. In the remaining patients, the first FS developed after 6 years of age. The mean observational period since the last outpatient follow-up visit was 3.2 years (median 3.04 years, range: 1.42-4.71 years). Among them, 21% developed an unprovoked seizure. Logistic regression analysis showed that electroencephalographic (EEG) abnormalities served as an independent risk factor for a subsequent unprovoked seizure. Conclusion: EEG is the proper diagnostic tool to predict the risk of a subsequent unprovoked seizure in patients with FS after 6 years of age.

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Subsequent Afebrile Seizure in Children Who Have a First Seizure With Fever After 6 Years of Age

Cited by 4 publications

References 16 publications

Prognosis in Late-Onset Febrile Seizure

Prognosis in Late-Onset Febrile Seizure

Incidence, prevalence and aetiology of seizures and epilepsy in children

The Prognostic Factors Affecting the Occurrence of Subsequent Unprovoked Seizure in Patients Who Present with Febrile Seizure after 6 Years of Age

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