Substance P-induced inhibition of Leydig cell steroidogenesis in primary culture

Angelova, P.; Davidoff, M; Kanchev, L.N.

doi:10.1111/j.1439-0272.1991.tb02572.x

Cited by 22 publications

(5 citation statements)

References 20 publications

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“…While in such a photosensitive species endocrine and behavioural responses to annual changes in daylength have been well documented (Reiter, 1980;Goldman & Elliott, 1988) data on the photoperiod-dependent modulation of paracrine control on gonadal steroidogenesis are lacking. The reported results confirm and extend our observations on the local regulatory role of SP (Angelova et al, 1991b). Its effect is more pronounced in the case of high steroidogenic activity in the testis of LD-animals.…”

Section: Discussionsupporting

confidence: 90%

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In vitro effects of substance P and arginine-vasopressin on testosterone production in Leydig cells of short and long photoperiodic hamsters

et al. 2009

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The aim of the present study was to determine the interaction between substance P (SP) and arginine-vasopressin (AVP) on basal and LH-stimulated testosterone production by Leydig cells isolated from hamsters kept under long or short days (LD-hamsters, SD-hamsters, respectively). SP inhibited the testosterone production of Leydig cells, its effect being more pronounced in the case of LH-stimulated steroidogenesis in LD-hamsters. Similarly, the addition of AVP to the culture medium resulted in a diminution of basal, as well as LH-stimulated testosterone secretions. When Leydig cells were co-incubated with SP (lO-'M) and AVP (10-7M), a strong inhibition of the testosterone production by 50-60% was established in LD-animals. However, even within the experimental circumstances in SD-hamsters, the modulation of testosterone production by SP and AVP was evident. The reported results suggest that there is an interference of two regulatory pathways, namely photoperiodic dependence and paracrine control of testicular steroidogenesis in hamsters.

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Section: Discussionsupporting

confidence: 90%

“…Leydig cells were isolated using the method described by Browne et al ( 1990; see also Angelova et al, 1991b). Briefly, the testes were removed aseptically, decapsulated and minced with a scalpel.…”

Section: Methodsmentioning

confidence: 99%

In vitro effects of substance P and arginine-vasopressin on testosterone production in Leydig cells of short and long photoperiodic hamsters

et al. 2009

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“…In mammals, SP expression can be located in Leydig cells within the testis (e.g., in rat) (Lasaga and Debeljuk, 2011) and SP treatment in vitro inhibits both basal (Angelova et al, 1991) and LH-induced testosterone production in Leydig cell culture (e.g., in hamster) (Angelova et al, 1996). However, it is still unclear if NKB is also expressed in Leydig cells, and to our knowledge, the functional role of NKB in steroid production has not been examined at the gonad level.…”

Section: Expression and Functions Of Nkb In The Gonadmentioning

confidence: 99%

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish

Lin

et al. 2014

General and Comparative Endocrinology

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In mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH). Its regulatory actions are mediated by a subpopulation of kisspeptin neurons within the arcuate nucleus with co-expression of NKB and dynorphin A (commonly called the "KNDy neurons"). By forming an "autosynaptic feedback loop" within the hypothalamus, the KNDy neurons can modulate gonadotropin-releasing hormone (GnRH) pulsatility and subsequent LH release in the pituitary. NKB regulation of LH secretion has been recently demonstrated in zebrafish, suggesting that the reproductive functions of NKB may be conserved from fish to mammals. Interestingly, the TAC3 genes in fish not only encode the mature peptide of NKB but also a novel tachykinin-like peptide, namely NKB-related peptide (or neurokinin F). Recent studies in zebrafish also reveal that the neuroanatomy of TAC3/kisspeptin system within the fish brain is quite different from that of mammals. In this article, the current ideas of "KNDy neuron" model for GnRH regulation and steroid feedback, other reproductive functions of NKB including its local actions in the gonad and placenta, the revised model of tachykinin evolution from invertebrates to vertebrates, as well as the emerging story of the two TAC3 gene products in fish, NKB and NKB-related peptide, will be reviewed with stress on the areas with interesting questions for future investigations.

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“…Different studies suggest the involvement of tachykinins or kisspeptins in androgen production by testes. Treatment of testicular sections or of isolated Leydig cells with SP or NKA reduced testosterone basal levels, as well as the increase induced by LH or hCG (human chorionic gonadotropin) [19,61,63,101]. In Sertoli cells, treatment with NKA in the presence of testosterone caused an increase in estrogen levels, suggesting an activation of aromatase [61].…”

Section: Testicular Steroidogenesismentioning

confidence: 99%

Tachykinins and Kisspeptins in the Regulation of Human Male Fertility

Blasco

Pinto

González-Ravina

et al. 2019

JCM

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Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility.

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Substance P-induced inhibition of Leydig cell steroidogenesis in primary culture

Cited by 22 publications

References 20 publications

In vitro effects of substance P and arginine-vasopressin on testosterone production in Leydig cells of short and long photoperiodic hamsters

In vitro effects of substance P and arginine-vasopressin on testosterone production in Leydig cells of short and long photoperiodic hamsters

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish

Tachykinins and Kisspeptins in the Regulation of Human Male Fertility

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