Substantiation of Application of Allogenic Fibroblasts in Treatment of Extensive Burns

Fistal, E. Ya.; Soloshenko, V. V.

doi:10.24884/0042-4625-2017-176-1-42-45

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Клиническая эффективность аллогенных фибробластов обусловлена их способностью продуцировать компоненты внеклеточного матрикса и факторы роста, в результате воздействия которых происходит стимуляция пролиферации аутологичных фибробластов и кератиноцитов [4,5]. Таким образом, есть все основания полагать, что трансплантация дермальных фибробластов способствует самостоятельной эпителизации пограничных ожогов, сокращает продолжительность эпителизации перфорационных ячеек и ускоряет подготовку донорских ран к повторному отбору трансплантатов [6,7]. К настоящему времени предложено большое число разнообразных природных и синтетических полимерных носителей, предназначенных для переноса культивированных клеток на раневую поверхность (коллаген, хитозан, глюкозаминогликаны и т.…”

Section: Introductionunclassified

Experience in the clinical use of allogeneic fibroblasts in patients with severe burns

Vagner

Zinoviev

Владимирович³

et al. 2018

HERALD of North-Western State Medical University named after I.

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Purpose. To evaluate the results of the application of allogenic fibroblasts in patients with extensive thermal burns. Methods. The study included 34 patients with burns over 20% TBSA, treated in the burn ICU. In accordance with the indications for transplantation of fibroblasts, all patients were divided into 4 groups: stimulation of regeneration of superficial burns (n = 10), stimulation of regeneration after meshed skin graft (n = 14), reduction of healing time for donor wounds (n = 6) and acceleration growth of granulations after the escharectomy (n = 4). Results. A positive effect of fibroblast transplantation was found in 7 (70%) patients of the first group, 13 (93%) of the patients in the second group, 2 (33%) of the third group and 2 (50%) in the fourth study group. Conclusion. The maximum positive effect of transplantation of human dermal fibroblasts can be observed when performing the meshed skin graft and treating the superficial burns.

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Section: Introductionunclassified

Experience in the clinical use of allogeneic fibroblasts in patients with severe burns

Vagner

Zinoviev

Владимирович³

et al. 2018

HERALD of North-Western State Medical University named after I.

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Modern aspects of the monitoring of a burn wound readiness for autodermoplasty

Zurnadzh'yants,

Kchibekov,

Ragimov

et al. 2024

jour

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The leading principle of burned patients’ treatment is to perform free autodermoplasty with split autodermografts. The main criterion for a successful plastic surgery is the percentage of engraftment of skin grafts. The issues of readiness of burn wounds for such surgical interventions continue to be studied and remain open at the present time. The degree of readiness of burn wounds for skin grafting is known to depend on many factors, among which the state of the microbial flora and the level of bacterial contamination of the wound surface play an important role as one of the main criteria for maintaining inflammation in the wound. The method of cytological examination of prints from burn wounds has found wide application, which is associated with the peculiarities of pathomorphological processes in burn wounds. Great importance is attached to studying the state of microcirculation in the wound using laser Doppler flowmetry in order to determine the perfusion and reparative ability of granulation tissue of a burn wound. However, in addition to local criteria, general condition of the body and the state of its immune system in particular should be taken into account. A great number of research works is devoted to the study of immune reactions in response to burn injury. The results of these studies also make it possible to identify certain criteria for predicting the success or chance of unsatisfactory outcomes of autodermoplasty. The levels of hemoglobin and total protein allowing to expect successful surgical treatment have been determined. In spite of the wide range of methods to determe the readiness of a wound for autodermoplasty, many of them are imperfect and nonspecific. The development of complications in the form of lysis or rejection of skin grafts, the maintenance of inflammatory processes, the development of a shortage of donor resources, mortality and the likelihood of developing severe cicatricial deformities in long-term results depend on the quality and timing of surgical treatment. Therefore, the problem of uniform criteria identification for the readiness of a burn wound surface for plastic surgery remains relevant for combustiologists and surgeons.

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Clinical and experimental studies of tissues in thermal injuries

2019

Actual Problems of Modern Medicine

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The article is devoted to studies used in the clinic and in the experiment in the study of tissue damage caused by exposure to high temperature. Determining the area and depth of tissue damage during thermal injury is of fundamental importance not only for treatment, but also for prognosis. The use of laser Doppler flowmetry, magnetic resonance imaging, pH-metry, contactless infrared thermometry of burn wounds, the method of assessing tissue viability based on the study of dielectric parameters allows to evaluate the viability and the state of damaged tissues in dynamics. The importance of tissue research methods for establishing an accurate diagnosis, assessing the readiness of wounds for autodermoplasty and determining the extent of surgical interventions is shown. The use of morphological methods in experimental studies and in the treatment of victims with burns is substantiated. Using histological and cytological methods, the condition of the burn wound is monitored, the efficacy of surgical interventions and the use of therapeutic agents is evaluated, the wound process phase is determined, and medical tactics is planned. The histochemical method is used to study the composition and state of the tissues of a burn wound paranecrosis area, and the immunohistochemical method is used to assess the intensity of regeneration processes by determining the tissue proliferation and differentiation markers. Ultramicroscopic examination of tissues at different times after thermal injury is informative for understanding the dynamics of pathomorphological changes in burns. Review of the pathogenesis of burn disease, taking into account the data of ultramicroscopic studies, creates the prospect of developing methods for targeted correction of the condition of patients with burns at the subcellular level. The role of experimental studies in the investigation of thermal damage, preclinical trials of medicinal products used to influence the wound process, improving the existing methods and developing the new ones for treatment of burn injury has been determined.

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Substantiation of Application of Allogenic Fibroblasts in Treatment of Extensive Burns

Cited by 3 publications

References 2 publications

Experience in the clinical use of allogeneic fibroblasts in patients with severe burns

Experience in the clinical use of allogeneic fibroblasts in patients with severe burns

Modern aspects of the monitoring of a burn wound readiness for autodermoplasty

Clinical and experimental studies of tissues in thermal injuries

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