Substituted Heterocyclic Thioureas I

Thiourea, triazole and thiadiazine compounds and their metal complexes as antifungal agents

“…On the other hand, functionalities bulkier than an allyl group at the R2 position also gave rise to almost complete loss of inhibition of mycobacterial growth. The fact that highest antituberculosis activity in phenylthioureas was observed for compounds with the terminal nitrogen substituted by a single short chain alkyl group, was also in agreement with previous reports [59,60].…”

“…In a previous work, Doub et al [59] revealed antituberculosis properties of a wide number of phenylthioureas (B). Glasser and Dougthy [60] also reported the same type of activity associated with a number of thiourea derivatives substituted with a heterocyclic ring at one nitrogen. The compounds were tested for antimycobacterial activity against Mycobacterium tuberculosis and Mycobacterium fortuitum, a rapidly growing opportunistic pathogen.…”

“…with a substituted thiourea moiety In 2001, Kü çü kgü zel et al[61] reported the synthesis of a series of novel N-alkyl/aryltriazole-3-thione-5-yl)phenyl] thioureas(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65) and three S-alkylated representatives of the former, N-alkyl/aryl-NO-…”

(E)-N′-(4-Chlorobenzylidene)-2-methoxybenzohydrazide

“…For applications and biological activity of hydrazone derivatives, see: Khan et al (2011Khan et al ( , 2012; Ku " çu " kgu " zel et al (1999); Patel et al (1984); Wilder (1967); Glasser & Doughty (1962). For a related structure, see: Cao (2009).…”

“…Data collection: SMART (Bruker, 2000); cell refinement: SAINT (Bruker, 2000); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL, PARST (Nardelli, 1995) and PLATON (Spek, 2009). Organic compounds based on the hydrazone moiety are well known due to their wide range of applications both in structural and medicinal chemistry (Khan et al, 2011(Khan et al, , 2012Kūçūkgūzel et al, 1999;Patel et al, 1984;Wilder, 1967;Glasser & Doughty, 1962). The title compound is a hydrazone derivative synthesized in order to evaluate its biological activities.…”