Glide symmetry, which is one kind of higher symmetry, is introduced in a special type of plasmonic metamaterial, the transmission lines (TLs) of spoof surface plasmon polaritons (SSPPs), in order to control the dispersion characteristics and modal fields of the SSPPs. We show that the glide-symmetric TL presents merged pass bands and mode degeneracy, which lead to broad working bandwidth and extremely low coupling between neighboring TLs. Dual-conductor SSPP TLs with and without glide symmetry are arranged in parallel as two channels with very deep subwavelength separation (e.g., λ 0 ∕100 at 5 GHz) for the application of integrated circuits and systems. Mutual coupling between the hybrid channels is analyzed using coupled mode theory and characterized in terms of scattering parameters and near-field distributions. We demonstrate theoretically and experimentally that the hybrid TL array obtains significantly more suppressed crosstalk than the uniform array of two nonglide symmetric TLs. Hence, it is concluded that the glide symmetry can be adopted to flexibly design the propagation of SSPPs and benefit the development of highly compact plasmonic circuits.