Substrate-protecting antiproteolytic agents for the prevention of pathological degradation of connective tissues. A review

Robert, A.M.

doi:10.1016/j.patbio.2011.12.001

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…MOF are widely present in food, such as apples, grapes, chocolate and red wine. MOF have been shown to protect (micro)vascular tissue via the stabilization of collagen and elastin [ 18 ]. While binding to these macromolecules, MOF prevent their degradation by temperature, oxidative stress, inflammation and proteinases [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Monomeric and Oligomeric Flavanols on Kidney Function, Inflammation and Oxidative Stress in Runners: A Randomized Double-Blind Pilot Study

et al. 2020

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Nonsteroidal anti-inflammatory drugs are frequently used by athletes in order to prevent musculoskeletal pain and improve performance. In combination with strenuous exercise, they can contribute to a reduction of renal blood flow and promote development of kidney damage. We aimed to investigate whether monomeric and oligomeric flavanols (MOF) could reduce the severity of kidney injuries associated with the intake of 400-mg ibuprofen followed by the completion of a half-marathon in recreational athletes. In this double-blind, randomized study, the original MOF blend of extracts from grape seeds (Vitis vinifera L.) and pine bark (Pinus pinaster L.) or placebo were taken for 14 days preceding the ibuprofen/half-marathon. Urine samples were collected before and after the ibuprofen/half-marathon, and biomarkers of kidney injury, inflammation and oxidative stress were assessed. Intake of MOF significantly reduced the incidence of post-race hematuria (p = 0.0004) and lowered concentrations of interleukin (IL)-6 in the urine (p = 0.032). Urinary neutrophil-associated lipocalin, creatine, albumin, IL-8 and malondialdehyde tended to decrease. The supplementation with MOF in recreational runners appears to safely preserve kidney function, reduce inflammation and promote antioxidant defense during strenuous exercise and intake of a single dose of ibuprofen.

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Section: Introductionmentioning

confidence: 99%

Effects of Monomeric and Oligomeric Flavanols on Kidney Function, Inflammation and Oxidative Stress in Runners: A Randomized Double-Blind Pilot Study

et al. 2020

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“…This antiproteolytic activity offered by the oligomeric flavan-3-ols present in the preparation has been classified as ‘substrate protection’, because the compounds do not primarily inhibit the proteinases that degrade the matrix-components but rather bind to the matrix macromolecules thus preventing degradation by various triggers such as temperature, oxidative stress, inflammation, proteinases among others [81]. …”

Section: Introductionmentioning

confidence: 99%

Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits

Weseler¹,

Bast²

2017

Nutr J

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Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect relationship between the intake of that product and its health effect. In this review we follow a specific grape seed extract containing monomeric and oligomeric flavan-3-ols from its creation by Jack Masquelier in 1947 towards a botanical remedy and nutraceutical with proven health benefits. The preparation’s research history parallels the advancing insights in the fields of molecular biology, medicine, plant and nutritional sciences during the last 70 years. Analysis of the extract’s flavanol composition emerged from unspecific colorimetric assays to precise high performance liquid chromatography - mass spectrometry and proton nuclear magnetic resonance fingerprinting techniques. The early recognition of the preparation’s auspicious effects on the permeability of vascular capillaries directed research to unravel the underlying cellular and molecular mechanisms. Recent clinical data revealed a multitude of favorable alterations in the vasculature upon an 8 weeks supplementation which summed up in a health benefit of the extract in healthy humans. Changes in gene expression of inflammatory pathways in the volunteers’ leukocytes were suggested to be involved in this benefit. The historically grown scientific evidence for the preparation’s health effects paves the way to further elucidate its metabolic fate and molecular action in humans.

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Longevity and aging, genetic and post-genetic mechanisms. Which target to choose for postponing and treating age-related diseases

Robert

2012

European Geriatric Medicine

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Substrate-protecting antiproteolytic agents for the prevention of pathological degradation of connective tissues. A review

Cited by 3 publications

References 30 publications

Effects of Monomeric and Oligomeric Flavanols on Kidney Function, Inflammation and Oxidative Stress in Runners: A Randomized Double-Blind Pilot Study

Effects of Monomeric and Oligomeric Flavanols on Kidney Function, Inflammation and Oxidative Stress in Runners: A Randomized Double-Blind Pilot Study

Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits

Longevity and aging, genetic and post-genetic mechanisms. Which target to choose for postponing and treating age-related diseases

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