2006
DOI: 10.1248/bpb.29.2362
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Substrate Selectivity of Monoamine Oxidase A, Monoamine Oxidase B, Diamine Oxidase, and Semicarbazide-Sensitive Amine Oxidase in COS-1 Expression Systems

Abstract: Amine oxidases (AOs) are widely distributed among all living organisms. 1) This class of enzymes is divided into two subclasses: FAD-containing amine oxidases (FAD-AOs) and Cu-containing amine oxidases (Cu-AOs). Two types of mitochondrial monoamine oxidases, monoamine oxidases (MAO)-A and MAO-B, and cytosolic polyamine oxidase are included in FAD-AOs.2) The Cu-AOs consist of retina amine oxidase, diamine oxidase (DAO), and semicarbazide-sensitive amine oxidase (SSAO), which is known as the tissue-bound or plas… Show more

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Cited by 26 publications
(14 citation statements)
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“…Two isoforms of MAO, i.e. MAO-A and MAO-B, have been identified according to differences in their specificities for inhibitors [20][21][22] and substrates [22][23][24][25]. MAO-A is inhibited by clorgyline at low nanomolar concentrations and this irreversible inhibitor has been used to estimate the turnover rate of MAO-A to be 2 days and recovery of MAO-A activity and protein levels after treatment with clorgyline to occur within 14 days [26].…”
Section: There Are Two Isoforms Of Maomentioning
confidence: 99%
“…Two isoforms of MAO, i.e. MAO-A and MAO-B, have been identified according to differences in their specificities for inhibitors [20][21][22] and substrates [22][23][24][25]. MAO-A is inhibited by clorgyline at low nanomolar concentrations and this irreversible inhibitor has been used to estimate the turnover rate of MAO-A to be 2 days and recovery of MAO-A activity and protein levels after treatment with clorgyline to occur within 14 days [26].…”
Section: There Are Two Isoforms Of Maomentioning
confidence: 99%
“…5) and/or one of the MAO isoforms on the outer mitochondrial membrane [48] further oxidised 1-MH cannot finally be answered by the results of the present study. A trend to increase the 1-MH appearance after inhibition of DAO with AG ( Fig.…”
Section: Discussionmentioning
confidence: 62%
“…1-MH can also be oxidised in a second step by DAO [45][46][47] or one of the monoamine oxidases, MAO-A or MAO-B [44,48]. Histamine catabolism by the mentioned enzymes is essentially an intracellular process.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…On its own, intracellular Hia can slow the G1/S progression of the cell cycle, as recently demonstrated in transfected human embryonic cells expressing active and inactive versions of HDC [5]. It can also act as a stress factor because it is degraded by amino oxidases [6]. Extracellular Hia can be taken up by organic cation transporters [7].…”
Section: Introduction: Previous Knowledge and Hypothesismentioning
confidence: 99%