Subthalamic deep brain stimulation improves auditory sensory gating deficit in Parkinson’s disease

Gulberti, Alessandro; Hamel, Wolfgang; Buhmann, Carsten; Boelmans, Kai; Zittel, Simone; Westphal, Manfred; Engel, Andreas K.; Schneider, Till R.; Moll, Christian K.E.

doi:10.1016/j.clinph.2014.06.046

Cited by 26 publications

(27 citation statements)

References 98 publications

(108 reference statements)

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“…Evidence from experiments in cognitive tasks points to modulation of brain network activity: EEG studies show that increased theta power in the medial prefrontal cortex associated with high-conflict tasks predicts increased time to decision, while STN-DBS reverses mediofrontal influence on decision thresholds. 17 Furthermore, intraoperative intracranial recordings in the STN show corresponding changes in low-frequency power during high-conflict tasks, suggesting communication with the medial prefrontal cortex. 12 In some cognitive and perceptual tasks, this can lead to increased errors, 14,16 however in our study, switching stimulation on made perceptual inference closer to that of controls.…”

Section: Reach Movement Metricsmentioning

confidence: 99%

“…found that chronic STN-DBS attenuated the effects of PD on auditory evoked potentials to rhythmic auditory stimuli, whereas transient interruptions to stimulation had no effect. 17 Using an overnight stimulation "washout", Koch et al (2004) showed that PD patients discriminated auditory inter-stimulus intervals more accurately on-stimulation than off-stimulation. 11 Extrapolating from these studies, STN-DBS may improve temporal discrimination in the RHI, strengthening the asynchronous signal, which would explain why our patients rejected the RHI more strongly in the asynchronous condition when in the 'on-stimulation' state.…”

Section: Reach Movement Metricsmentioning

confidence: 99%

“…We reasoned that improved processing of visual, somatosensory and temporal cues on stimulation [8][9][10][11][17][18][19] would lead to a more typical rejection of the RHI when visual-tactile cues are asynchronous. We expected to see this only in the asynchronous condition because, in our previous study, PD had no effect on illusion scores in the synchronous condition.…”

Section: Introductionmentioning

confidence: 99%

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Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion

Ding

Palmer

Hohwy

et al. 2017

Preprint

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Parkinson's disease (PD) alters cortico-basal ganglia-thalamic circuitry and susceptibility to an illusion of bodily awareness, the Rubber Hand Illusion (RHI). Bodily awareness is thought to result from multisensory integration in a predominantly cortical network; the role of subcortical connections is unknown. We studied the effect of modulating cortico-subcortical circuitry on multisensory integration for bodily awareness in PD patients treated with peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/231340 doi: bioRxiv preprint first posted online subthalamic nucleus (STN) deep brain stimulation (DBS) using the RHI experiment.Typically, synchronous visuo-tactile cues induce a false perception of touch on the rubber hand as if it were the subject's hand, whereas asynchronous visuo-tactile cues do not.However, we found that in the asynchronous condition, patients in the off-stimulation state did not reject the RHI as strongly as healthy controls; switching on STN-DBS partially 'normalised' their responses. Patients in the off-stimulation state also misjudged the position of their hand, indicating it to be closer to the rubber hand than controls. However, STN-DBS did not affect proprioceptive judgements or subsequent arm movements altered by the perceptual effects of the illusion. Our findings support the idea that the STN and subcortical connections have a key role in multisensory integration for bodily awareness. Decisionmaking in multisensory bodily illusions is discussed.

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Section: Reach Movement Metricsmentioning

confidence: 99%

Section: Reach Movement Metricsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion

Ding

Palmer

Hohwy

et al. 2017

Preprint

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“…Both EEG sessions can be recorded on the same day consecutively without electrode repositioning between sessions (Devos et al 2004). Alternating EEG recordings with DBS ON and OFF requires to be careful about the DBS washout effect: when turning the stimulator OFF, there might be still ongoing DBS ON carry over effects (Gulberti et al 2015b), such as the modulation of synaptic plasticity induced by chronic DBS that is not washed out by brief DBS discontinuation (Gulberti et al 2015a;Quraan et al 2014). Therefore, it is important to wait sufficiently long, given the ethically acceptable conditions that depend on the pathology, between the DBS setting modification and the beginning of task-related behavioral and EEG recordings.…”

Section: Task-related Evoked Responsesmentioning

confidence: 99%

“…In OCD patients, it was used to study the role of the associative-limbic STN on the cortical networks of motor inhibition during a stop signal task (Kibleur et al 2016). The same methodology was also used to study ERPs amplitude and latency modulation by DBS on visual evoked potentials (Jech et al 2006;Priori et al 2001), in a passive rhythmic auditory stimulation task (Gulberti et al 2015b), in a working memory task (Selzler et al 2013) and in an auditory Go/NoGo task in PD patients stimulated in the STN (Gerschlager et al 1999; and on SEPs in PD patients with STN (Priori et al 2001;Conte et al 2010;Insola et al 2005) and GPi DBS (Pierantozzi et al 1999). As for SCEPs, the reconstruction of ERP sources, for example using minimum norm (Kibleur et al 2016) or multiple sparse priors (Kibleur et al 2017), can help defining the projection of DBS modulation on cortical regions activated by the specific cognitive tasks.…”

Section: Task-related Evoked Responsesmentioning

confidence: 99%

Electroencephalographic read-outs of the modulation of cortical network activity by deep brain stimulation

Kibleur

David

2018

Bioelectron Med

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Deep brain stimulation (DBS), a reversible and adjustable treatment for neurological and psychiatric refractory disorders, consists in delivering electrical currents to neuronal populations located in subcortical structures. The targets of DBS are spatially restricted, but connect to many parts of the brain, including the cortex, which might explain the observed clinical benefits in terms of symptomatology. The DBS mechanisms of action at a large scale are however poorly understood, which has motivated several groups to recently conduct many research programs to monitor cortical responses to DBS. Here we review the knowledge gathered from the use of electroencephalography (EEG) in patients treated by DBS. We first focus on the methodology to record and process EEG signals concurrently to DBS. In the second part of the review, we address the clinical and scientific benefits brought by EEG/DBS studies so far.

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Neurophysiological investigation of auditory intensity dependence in patients with Parkinson’s disease

et al. 2021

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There is accumulating evidence for auditory dysfunctions in patients with Parkinson's disease (PD). Moreover, a possible relationship has been suggested between altered auditory intensity processing and the hypophonic speech characteristics in PD. Nonetheless, further insight into the neurophysiological correlates of auditory intensity processing in patients with PD is needed primarily.In the present study, high-density EEG recordings were used to investigate intensity dependence of auditory evoked potentials (IDAEPs) in 14 patients with PD and 14 age-and gendermatched healthy control participants (HCs). Patients with PD were evaluated in both the on-and offmedication states. HCs were also evaluated twice.Significantly increased IDAEP of the N1/P2 was demonstrated in patients with PD evaluated in the on-medication state compared to HCs. Distinctive results were found for the N1 and P2 component. Regarding the N1 component, no differences in latency or amplitude were shown between patients with PD and HCs regardless of the medication state. In contrast, increased P2 amplitude was demonstrated in patients with PD evaluated in the on-medication state compared to the off-medication state and HCs.In addition to a dopaminergic deficiency, deficits in serotonergic neurotransmission in PD were shown based on increased IDAEP. Due to specific alterations of the N1-P2 complex, the current results suggest deficiencies in early-attentive inhibitory processing of auditory input in PD. This interpretation is consistent with the involvement of the basal ganglia and the role of dopaminergic and serotonergic neurotransmission in auditory gating.

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Subthalamic deep brain stimulation improves auditory sensory gating deficit in Parkinson’s disease

Cited by 26 publications

References 98 publications

Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion

Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion

Electroencephalographic read-outs of the modulation of cortical network activity by deep brain stimulation

Neurophysiological investigation of auditory intensity dependence in patients with Parkinson’s disease

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