Subthalamic Local Field Beta Oscillations during Ongoing Deep Brain Stimulation in Parkinson’s Disease in Hyperacute and Chronic Phases

Abstract

In the past years, local field potential (LFP) signals recorded from the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) for Parkinson’s disease (PD) disclosed that DBS has a controversial effect on STN beta oscillations recorded 2–7 days after surgery for macroelectrode implantation. Nothing is known about these DBS-induced oscillatory changes 30 days after surgery. We recorded STN LFPs during ongoing DBS in 7 patients with PD, immediately (hyperacute phase) and 30 days (chronic phase) after surgery. STN LFP recordings showed stationary intranuclear STN beta LFP activity in hyperacute and chronic phases, confirming that beta peaks were also present in chronic recordings. Power spectra of nuclei with significant beta activity (54% of the sample) showed that it decreased significantly during DBS (p = 0.021) under both recording conditions. The time course of beta activity showed more evident DBS-induced changes in the chronic than in the hyperacute phase (p = 0.014). DBS-induced changes in STN beta LFPs in patients undergoing DBS in chronic phase provide useful information for developing a new neurosignal-controlled adaptive DBS system.

Neural origin of evoked potentials during thalamic deep brain stimulation

“…One potential closed-loop feedback signal is the local field potential (LFP) recorded from the DBS electrode and reflecting synchronized network activity (Marceglia et al 2007;Santaniello et al 2011) that is correlated to motor symptoms in PD (Smirnov et al 2008;Tass et al 2010) and ET (Kane et al 2009). Beta band (13-35 Hz) activity in PD (Brown and Williams 2005) and theta band (4 -7 Hz) activity in ET (Kane et al 2009) are disrupted by DBS (Bronte-Stewart et al 2009;Eusebio et al 2012;Ray et al 2008;Rosa et al 2011;Santaniello et al 2011), suggesting that LFP recordings might be used to identify clinically effective stimulation parameters (Yoshida et al 2010). Additionally, a closed-loop internal globus pallidus (GPi)-DBS system used single-unit activity from primary motor cortex (M1) as a trigger for each stimulus pulse and demonstrated greater symptom reduction than continuous, open-loop stimulation (Rosin et al 2011).…”

“…Beta band (13-35 Hz) activity in PD (Brown and Williams 2005) and theta band (4 -7 Hz) activity in ET (Kane et al 2009) are disrupted by DBS (Bronte-Stewart et al 2009;Eusebio et al 2012;Ray et al 2008;Rosa et al 2011;Santaniello et al 2011), suggesting that LFP recordings might be used to identify clinically effective stimulation parameters (Yoshida et al 2010). Additionally, a closed-loop internal globus pallidus (GPi)-DBS system used single-unit activity from primary motor cortex (M1) as a trigger for each stimulus pulse and demonstrated greater symptom reduction than continuous, open-loop stimulation (Rosin et al 2011).…”

The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease

“…A possible explanation for this limitation is that even though PD motor disturbances fluctuate, DBS is delivered with constant settings (reprogrammable only at follow-up visits). One way to improve the clinical results would therefore be to develop neuromodulatory strategies based on a neurosignal that could adapt moment-by-moment (online) to the individual patient's clinical condition [8,9]. Electrodes implanted in the brain for DBS record neural activity through local field potentials (LFPs) from large neuronal ensembles [10,11,12].…”

“…In patients with PD, LFPs can be recorded from the first choice target for DBS - the subthalamic nucleus (STN) [1]. STN LFP oscillations are specifically modulated during movement, during cognitive and behavioral tasks, and by various treatments [3,9,11,13,14,15,16,17,18,19,20,21,22,23,24,25,26]. Pathophysiological LFP rhythms recorded from the STN in parkinsonian patients oscillate in the low-frequency (LF) band (2-7 Hz) [15], beta band (8-30 Hz) [19,20], gamma band (60-90 Hz) [27] and high-frequency band (>200 Hz) [28,29,30].…”

“…Pathophysiological LFP rhythms recorded from the STN in parkinsonian patients oscillate in the low-frequency (LF) band (2-7 Hz) [15], beta band (8-30 Hz) [19,20], gamma band (60-90 Hz) [27] and high-frequency band (>200 Hz) [28,29,30]. LFPs remain stable weeks after DBS electrode implantation [9]. For all these reasons, LFPs have been proposed as potential control variables to adjust DBS settings online according to the patient's clinical condition [8].…”