Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease

Herzog, Jan; Weiss, Peter H.; Assmus, A.; Wefer, B.; Seif, C.; Braun, P.; Herzog, Hans; Volkmann, Jens; Deuschl, Günther; Fink, Gereon R.

doi:10.1093/brain/awl302

Cited by 137 publications

(85 citation statements)

References 66 publications

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“…The location of peak activity in STN identified both in the current study and in Aron and Poldrack appeared to be somewhat medial to the MNI coordinates specified in previous studies (e.g., x=18, right STN, x=−16, left STN, Herzog et al, 2006). Thus, we overlay the BOLD activation for long>short SSRT on coronal and axial sections of a single-subject T1 structural image in order to better visualize the approximate locations of the STNs (Fig.…”

Section: Neural Activity Differentiating Individuals With Short and Lsupporting

confidence: 50%

Subcortical processes of motor response inhibition during a stop signal task

et al. 2008

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This PDF receipt will only be used as the basis for generating PubMed Central (PMC) documents. PMC documents will be made available for review after conversion (approx. 2-3 weeks time). Any corrections that need to be made will be done at that time. No materials will be released to PMC without the approval of an author. Only the PMC documents will appear on PubMed Central --this PDF Receipt will not appear on PubMed Central.Previous studies have delineated the neural processes of motor response inhibition during a stop signal task, with most reports focusing on the cortical mechanisms. A recent study highlighted the importance of sub-cortical processes during stop signal inhibition in 13 individuals and suggested that the subthalamic nucleus (STN) may play a role in blocking response execution (Aron and Poldrack, 2006). Here in a functional magnetic resonance imaging (fMRI) study we replicated the finding of greater activation in the STN during stop (success or error) trials, compared to go trials, in a larger sample of subjects (n=30). However, since a contrast between stop and go trials involved processes that could be distinguished from response inhibition, the role of subthalamic activity during stop signal inhibition remained to be specified. To this end we followed an alternative strategy to isolate the neural correlates of response inhibition (Li et al., 2006a). We compared individuals with short and long stop signal reaction time (SSRT) as computed by the horse race model. The two groups of subjects did not differ in any other aspects of stop signal performance. We showed greater activity in the short than the long SSRT group in the caudate head during stop successes, as compared to stop errors. Caudate activity was positively correlated with medial prefrontal activity previously shown to mediate stop signal inhibition. Conversely, bilateral thalamic nuclei and other parts of the basal ganglia, including the STN, showed greater activation in subjects with long than short SSRT. Thus, fMRI delineated contrasting roles of the prefrontal-caudate and striato-thalamic activities in mediating motor response inhibition.

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Section: Neural Activity Differentiating Individuals With Short and Lsupporting

confidence: 50%

Subcortical processes of motor response inhibition during a stop signal task

et al. 2008

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“…Other studies have shown that DBS of the STN positively influences urodynamic parameters during the storage phase (Finazzi-Agro et al, 2003). A recent study has demonstrated that this improvement of urinary bladder function is related to a decreased activation of the ACC and lateral PFC during bladder filling, which could be a consequence of the improvement of the continence (Herzog et al, 2006).…”

Section: Effect Of Dbs On Vegetative/autonomic Functionsmentioning

confidence: 94%

PET functional imaging of deep brain stimulation in Parkinson’s disease

Thobois

Broussolle

2012

Journal of Neurolinguistics

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“…By using PET signals to observe regional cerebral blood flow (rCBF), bladder filling was found to significantly increase rCBF in the anterior cingulate gyrus and lateral frontal cortex. DBS improved the coordinated cortical control of pelvic floor muscle activity and eliminated supplemental motor and pre-motor activity resulting in the potential for improved UI in PD patients [15]. Further study of functional incontinence outcomes appears to be warranted by this initial innovative trial.…”

Section: Spinal and Deep Brain Stimulationmentioning

confidence: 98%

Diagnosis and Management of Stress Urinary Incontinence in Females With Neurogenic Disease

Satyanarayan

Gliga

Lemack

2015

Curr Bladder Dysfunct Rep

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Women with a wide variety of neurological conditions, including multiple sclerosis (MS), Parkinson's disease (PD), cerebrovascular accidents (CVA), and spinal cord injury (SCI) frequently develop neurovesical dysfunction, commonly resulting in what is often called neurogenic bladder (NGB). The most common manifestations of NGB are urinary urgency, frequency, and urgency urinary incontinence (UUI). However, because many women with NGB conditions lead active lifestyles and are at an age when stress urinary incontinence (SUI) is prevalent, indeed, SUI is not uncommon in affected women. It is also true that, in some conditions, SUI may be a direct result of the neurological insult, for example, patients with low thoracic or lumbar SCI. Thus, deciphering the cause of urinary incontinence in patients with NGB is often complex, yet vital to developing optimal management strategies. This review focuses on the recent literature regarding both the diagnosis and treatment of SUI in women with NGB. In particular, specific strategies that may be essential in evaluating women with NGB and urinary incontinence (UI) will be discussed. Additionally, we will discuss both treatments uniquely applicable to patients with NGB and SUI as well as common treatments that might have unique risks and adaptations in women with NGB. From this review, it is clear that, as standardized practice and technologies continue to grow for management of SUI in patients with comorbid neurological conditions, additional research and analysis may be required to determine the complexities of this unique disease process.

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Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease

Cited by 137 publications

References 66 publications

Subcortical processes of motor response inhibition during a stop signal task

Subcortical processes of motor response inhibition during a stop signal task

PET functional imaging of deep brain stimulation in Parkinson’s disease

Diagnosis and Management of Stress Urinary Incontinence in Females With Neurogenic Disease

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