Subtissue Imaging and Thermal Monitoring of Gold Nanorods through Joined Encapsulation with Nd‐Doped Infrared‐Emitting Nanoparticles

Rocha, Uéslen; Hu, J. F.; Ванецев, А. С.; Rähn, Mihkel; Sammelselg, Väinö; Orlovskii, Yu.V.; Solé, J. Garcı́a; Jaque, Daniel; Ortgies, Dirk H.

doi:10.1002/smll.201600866

Cited by 41 publications

(25 citation statements)

References 54 publications

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“…To construct this kind of NP, one direct way is to combine two nanosized elements into a single nanostructure: one acts as nanoheater and the other provides thermal sensing capacity. For example, Rocha et al successfully encapsulated gold nanorods and LaF 3 :Nd NPs into single poly(lactic‐co‐glycolic acid) capsule, leading to the ability of thermally monitoring subcutaneous PTT. However, this kind of “double particle” approach increases the complexity and instability of the system.…”

Section: Therapeutic Applications Of 808 Nm‐excited Lnnpsmentioning

confidence: 99%

808‐nm‐Light‐Excited Lanthanide‐Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications

et al. 2017

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808 nm-light-excited lanthanide (Ln )-doped nanoparticles (LnNPs) hold great promise for a wide range of applications, including bioimaging diagnosis and anticancer therapy. This is due to their unique properties, including their minimized overheating effect, improved penetration depth, relatively high quantum yields, and other common features of LnNPs. In this review, the progress of 808 nm-excited LnNPs is reported, including their i) luminescence mechanism, ii) luminescence enhancement, iii) color tuning, iv) diagnostic and v) therapeutic applications. Finally, the future outlook and challenges of 808 nm-excited LnNPs are presented.

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Section: Therapeutic Applications Of 808 Nm‐excited Lnnpsmentioning

confidence: 99%

808‐nm‐Light‐Excited Lanthanide‐Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications

et al. 2017

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“…Numerous approaches have been developed to attain highly sensitive intracellular thermometry methods, including fluorescent probes 14 – 18 and nanodiamonds 11 , 19 , but they are limited by spatiotemporal resolution. Spatial resolution could be improved by the encapsulation of photothermal agents with a thermometer 20 or scanning-based strategies 21 , 22 , but the detection speed keeps the temporal resolution far from the aim of imaging the transient heat generation. Integration of the photothermal material (for example, gold nanorods) and thermosensitive polymers may be the solution due to distinct photothermal properties and the mechanoresponse.…”

Section: Introductionmentioning

confidence: 99%

Imaging the transient heat generation of individual nanostructures with a mechanoresponsive polymer

et al. 2017

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Measuring the localized transient heat generation is critical for developing applications of nanomaterials in areas of photothermal therapy (PTT), drug delivery, optomechanics and biological processes engineering. However, accurate thermometry with high spatiotemporal resolution is still a challenge. Here we develop a thermosensitive polymer-capped gold nanorod (AuNRs@pNIPAAm), which has temperature-dependent local surface plasmon resonance spectra due to the submolecular conformational change of pNIPAAm molecules. We measure the conformational dynamics on individual gold nanorods at the milliseconds level by the developed spatiotemporal resolution plasmonic spectroscopy (SRPS) and find that it has a fast (<4 ms), linear and reversible mechanoresponse to temperature changes as small as 80 mK. The rapid and highly sensitive thermosensitive AuNRs@pNIPAAm opens a new way to achieve spatiotemporal thermometry for potential applications in PTT and other biological research.

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“…They also demonstrated multimodal bioimaging by forming hybrid structures. In addition, the combination of NIR emissive Ln 3+ ‐doped UCNPs with AuNRs had shown the subtissue localization at NIR II window and thermal monitoring ability by using chicken breast tissue . These reports indicated that imaging at NIR II window might be a future trend for FI.…”

Section: Discussionmentioning

confidence: 93%

Cutting‐Edge Nanomaterials for Advanced Multimodal Bioimaging Applications

2017

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The desire for high sensitivity, resolution, low toxicity, and fast clearance contrast agents has driven the research for new nanomaterial systems. The drawbacks of traditional molecular probes limit their bioimaging ability, hence the exploration of emerging nanomaterials for multimodal bioimaging continues with rational designs. The key for realizing effective multimodal bioimaging is harnessing the physical and chemical properties of the nanomaterials. Although some nanomaterials possess multimodality intrinsically, those imaging modes may not be sufficient to meet the increasing demands of various applications. Therefore, the fabrication of novel composite structures by integrating various nanomaterials or molecules may overcome the challenging issues in multimodal bioimaging. An overview and considerations for multimodal bioimaging and the requirements regarding the nanomaterials are presented. The recently emerged nanomaterials and their composite structures for multimodal bioimaging are highlighted, including the recently emerging 2D materials. The traditional nanomaterials also show breakthroughs in terms of novel structures and morphologies, which would affect the contrast ability, entrance, and clearance from the in vivo models. Finally, some suggestions for toxicity studies of nanomaterials and new strategies are presented for realizing the advance of multimodal bioimaging.

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Subtissue Imaging and Thermal Monitoring of Gold Nanorods through Joined Encapsulation with Nd‐Doped Infrared‐Emitting Nanoparticles

Cited by 41 publications

References 54 publications

808‐nm‐Light‐Excited Lanthanide‐Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications

808‐nm‐Light‐Excited Lanthanide‐Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications

Imaging the transient heat generation of individual nanostructures with a mechanoresponsive polymer

Cutting‐Edge Nanomaterials for Advanced Multimodal Bioimaging Applications

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