Subtotal splenectomy preserving the inferior splenic pole for the treatment of Hodgkin’s lymphoma

Petroianu, Andy

doi:10.1016/j.ijscr.2017.04.015

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…The spleen is the largest lymphoid organ, serving the function of the body's defense in removing foreign particles from the blood, as well as playing a pivotal role in the bilirubin, lipids, and amino acids metabolism [ 1 ]. This organ also controls the circulating leukocytes and platelets, as well as the maturation of the lymphocytes, among other activities, such as the removal of old red blood cells and the storage of metals, especially iron from the metabolism of hemoglobin [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in splenic uptake pattern associated with X-ray irradiation

Faria

Petroianu

Campos

et al. 2020

Heliyon

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Purpose To evaluate the splenic uptake function after irradiation with high-energy X-rays. Materials and methods Fourteen male Wistar rats were distributed into three groups. Group 1 (n = 6) – control, non-irradiated; Group 2 (n = 4) – animals that were irradiated and studied 24 h after irradiation; and Group 3 (n = 4) – animals that were irradiated and studied 48 h after irradiation. The animals were irradiated with 8 Gy X-rays in the abdominal region. According with the groups, after 24 or 48 h, 1 ml/kg of a 50% colloidal carbon solution was injected in the left internal jugular vein. After 40 min, the spleens were removed for histological studies. Macrophages containing carbon pigments in their cytoplasms were counted in 16 consecutive microscopic fields, and their means were considered as the uptake pattern of each animal. Results In the control groups, carbon pigments were captured by macrophages in the red and white pulps, while in the irradiated groups, the uptake in the marginal zone, around the white pulp, was enhanced. There was no disorder on the splenic parenchyma or necrosis in histological analyzes. Qualitatively rare apoptotic events were observed, with no difference between control and irradiated animals. Conclusion The high-energy X-ray, used in radiotherapy, modifies the splenic clearance, enhancing the amount of marginal zone macrophages containing colloid particles. This radiation was not associated with morphological changes, nor with necrosis or apoptosis of splenic tissue.

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Section: Introductionmentioning

confidence: 99%

Changes in splenic uptake pattern associated with X-ray irradiation

Faria

Petroianu

Campos

et al. 2020

Heliyon

Self Cite

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“…22 Compared with surgical resection alone, surgical excision plus postoperative radiotherapy can greatly increase oral and maxillofacial malignancy local control and long-term survival rates. 5,23 However, the conventional external beam radiotherapy can seriously damage normal tissues, leading to oral mucositis, hemorrhage, xerostomia, radiation caries and orradionecrosis of the jaws. 11,24 Precision radiotherapy aims to improve radiation curative effects and reduce side effects by targeting lesions with more precise radiation doses and protect normal tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative radiotherapy is usually applied for high‐grade malignant tumors and nerve‐involved tumors 22 . Compared with surgical resection alone, surgical excision plus postoperative radiotherapy can greatly increase oral and maxillofacial malignancy local control and long‐term survival rates 5,23 . However, the conventional external beam radiotherapy can seriously damage normal tissues, leading to oral mucositis, hemorrhage, xerostomia, radiation caries and orradionecrosis of the jaws 11,24 .…”

Section: Discussionmentioning

confidence: 99%

MR‐guided 125I seed implantation treatment for maxillofacial malignant tumor

Wang

Peng

et al. 2020

J Applied Clin Med Phys

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PurposeThis study assessed the therapeutic efficacy of postoperative magnetic resonance (MR)‐guided interstitial 125I seed implantation for treatment of oral and maxillofacial malignant tumors.Methods and MaterialsA total of 127 patients with oral or maxillofacial malignant tumors were included in this study who received interstitial 125I treatment after the surgery resection. Before implantation, all the patients received MR scans to assess the lesion scope, extent, and nature. 125I implantation target regions were based on the pre‐operative imaging. 125I seeds were delivered to target regions via puncture needles under the real‐time guidance of MR. Computed tomography (CT)or MR was performed immediately after implantation and again every 3 months later.ResultsAfter successful 125I implantation, all patients were also examined regularly to detect tumor recurrence, lymphatic, and distant metastases. To date, CT or MR verification showed that 13/127 patients experienced tumor recurrence or lymphatic metastasis or distant metastasis. No seeds migration was observed, no serious treatment‐related complications affected patient quality of life, and no important organ (such as major cervical vessels, spinal cord, etc.) injuries were observed.ConclusionOur results show that MR‐guided 125I implantation is an effective approach to site‐specific treatment for oral and maxillofacial tumor, which could potentially reduce postoperative complications and tumor recurrence rates, increase patient survival, and improve quality of life.

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“…More recently, this technique has been the subject of a review study 11 . A more current study still deals with subtotal splenectomy with preservation of the lower pole in patients with Hodgkin’s lymphoma 12 . Other studies on subtotal splenectomy with preservation of the lower pole in last five years have been published 13 - 14 .…”

Section: Introductionmentioning

confidence: 99%

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

et al. 2020

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Purpose To evaluate the viability of the upper (UP) and lower pole (LP) of the spleen from a macro and microscopic point of view, after subtotal splenectomy with preservation (SSP) of the UP and the LP. Methods Seventeen male Wistar rats, two months old, were submitted to SSPUP and SSPLP and 5 to simulated operation (SG). After 80 days, the rats were euthanized, and the remaining LP and UP and intact spleens were evaluated macroscopically and microscopically. Results Two rats died during the operation. Macroscopic analysis showed that in 15 LP, one of them was not viable and in 15 UP and in 5 spleens in the SG, all were viable. In the statistical analysis, there was no difference in relation to viability. The LP and UP analyzed showed variation. As for the length, the UP increased significantly; however, in relation to the width, there was a significant increase in the LP in relation to the UP. In addition, the weight of the UP was significantly greater than that of the LP. Microscopic analysis attested viability of the splenic remnants. Conclusion There was no significant difference regarding the viability of UP and LP, in macroscopy and microscopy.

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Subtotal splenectomy preserving the inferior splenic pole for the treatment of Hodgkin’s lymphoma

Cited by 7 publications

References 15 publications

Changes in splenic uptake pattern associated with X-ray irradiation

Changes in splenic uptake pattern associated with X-ray irradiation

MR‐guided 125I seed implantation treatment for maxillofacial malignant tumor

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

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