2023
DOI: 10.3389/fimmu.2023.1148483
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Subtype classification based on t cell proliferation-related regulator genes and risk model for predicting outcomes of lung adenocarcinoma

Abstract: BackgroundLung adenocarcinoma (LUAD), the major lung cancer histotype, represents 40% lung cancers. Currently, outcomes are remarkably different in LUAD patients with similar AJCC/UICC-TNM features. T cell proliferation-related regulator genes (TPRGs) relate to the proliferation, activity and function of T cells and tumor progression. The values of TPRGs in classifying LUAD patients and predicting outcomes remain unknown.MethodsGene expression profile and corresponding clinical data were downloaded from TCGA a… Show more

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Cited by 5 publications
(5 citation statements)
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“…Interdisciplinary analyses based on large amounts of sequencing data and diverse bioinformatics algorithms are increasingly being used for the identification of tumor subtypes, providing a valuable reference in the discovery of potential biomarkers [40][41][42][43]. In this study, a combined analysis of single-cells and bulk RNA sequencing was performed to construct a CAFRss comprising 11 CAFsrelated genes.…”
Section: Discussionmentioning
confidence: 99%
“…Interdisciplinary analyses based on large amounts of sequencing data and diverse bioinformatics algorithms are increasingly being used for the identification of tumor subtypes, providing a valuable reference in the discovery of potential biomarkers [40][41][42][43]. In this study, a combined analysis of single-cells and bulk RNA sequencing was performed to construct a CAFRss comprising 11 CAFsrelated genes.…”
Section: Discussionmentioning
confidence: 99%
“…TBDs are emerging multisystem cancer‐predisposition syndromes associated with a higher risk of benign and malignant hematolymphoid and solid neoplasms, described particularly in the context of POT1 genetic mutations [ 14 , 15 , 16 , 17 , 18 , 19 ]. More recently, genetic anticipation has been described in successive generations with heterozygous POT1 gene defects [ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…RT-qPCR was carried out as we previously described [ 7 , 22 , 23 ]. RT-qPCR primers for PDGFRL (forward: 5’GACGACATCAGTGTGCTCTGCA3’, revers: 5’CCAAGTGTCTTGGATCGTCACAG3’).…”
Section: Methodsmentioning
confidence: 99%
“…MTT, wound healing and transwell experiments were also performed according to our previous protocol [ 7 , 22 , 23 ].…”
Section: Methodsmentioning
confidence: 99%
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