Successful Autologous Stem Cell Therapy in Premature Ovarian Failure

Edessy, Mahmoud

doi:10.15406/mojwh.2015.01.00013

Cited by 2 publications

(2 citation statements)

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“…In the study of Eddesy et al, 10 women presenting with idiopathic POF were subjected to MSC autologous ovarian transplantation. Recovery of menstruation was achieved 3 months following autologous MSC transplantation for two patients and a subsequent live birth of a healthy offspring has been documented 31 . In another study published by Gabr et al, 30 women with idiopathic POF were also subjected to MSC autologous ovarian transplantation.…”

Section: Stem Cell Transplantationmentioning

confidence: 93%

Novel Approaches in Addressing Ovarian Insufficiency in 2019: Are We There Yet?

Sfakianoudis¹,

Rapani

Grigoriadis

et al. 2020

Cell Transplant

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Ovarian insufficiency is described as a multifaceted issue typically encountered in the field of assisted reproduction. The three main identified diagnoses of ovarian insufficiency include premature ovarian failure (POF), poor ovarian response (POR), and advanced maternal age (AMA). Patient heterogeneity in the era of individualized medicine drives research forward leading to the emergence of novel approaches. This plethora of innovative treatments in the service of adequately managing ovarian insufficiency is called to undertake the challenge of addressing infertile patients exploring their reproductive options. This review provides an all-inclusive presentation and critical analysis on novel treatments that have not achieved routine clinical practice status yet, but have recently emerged as promising. In light of the lack of randomized controlled trials conveying safety and efficiency, clinicians are left puzzled in addressing the “how” and “for whom” these approaches may be beneficial. From ovarian injection employing platelet-rich plasma (PRP) or stem cells to artificial gametes and ovaries, ovarian transplantation, and mitochondrial replacement therapy, this descriptive review provides insight toward assisting the practitioner in decision making regarding these cutting-edge treatments. Biological mechanisms, invasiveness levels, efficiency, as well as possible complications, the current status along with bioethical concerns are discussed in the context of identifying future optimal treatment.

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Section: Stem Cell Transplantationmentioning

confidence: 93%

Novel Approaches in Addressing Ovarian Insufficiency in 2019: Are We There Yet?

Sfakianoudis¹,

Rapani

Grigoriadis

et al. 2020

Cell Transplant

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“…Stem cells transplantation showed promising results for POI cases as regard clinical, histopathological, and immunohistochemical outcomes [39] .…”

Section: Stem Cells Transplantationmentioning

confidence: 99%

Female Fertility Preservation: Current & Future Strategies

Sallam

Hemida

2022

Mansoura Medical Journal

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Recently, the spectacular progress in diagnosis, treatment, and prognosis of different malignancies has increased the demands on fertility preservation. Fertility impairment is considered one of the complications of radio/cytotoxic treatments in females who managed to overcome their cancer. This issue of fertility preservation also concerns those who are at risk of developing ovarian failure as well as healthy individuals who aim to overcome age-related fertility decline. Regarding female fertility preservation, there are various options that could be selected according to various factors, including the patient's age, type of the disease, as well as type and urgency of treatment. Among these options, embryo/oocyte cryopreservation as well as ovarian tissue cryopreservation and autotransplantation are the most reliable modalities for post-and pre-pubertal patients, respectively. Moreover, novel techniques such as the artificial ovary, isolation and cryopreservation of follicles and immature oocyte, potential pharmacological gonadoprotective agents, and stem cells transplantation have the potential to be used in the future. In this article, current and future female fertility preservation strategies are highlighted.

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Successful Autologous Stem Cell Therapy in Premature Ovarian Failure

Cited by 2 publications

References 0 publications

Novel Approaches in Addressing Ovarian Insufficiency in 2019: Are We There Yet?

Novel Approaches in Addressing Ovarian Insufficiency in 2019: Are We There Yet?

Female Fertility Preservation: Current & Future Strategies

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