Successful case of adult ABO-incompatible liver transplantation: Beneficial effects of intrahepatic artery infusion therapy: A case report

Single-Center Experience of ABO-Incompatible Living-Donor Liver Transplantation With a New Simplified Intravenous Immunoglobulin Protocol: A Propensity Score-Matching Analysis

“…In fact, the outcomes of ABO-I LT have markedly improved since 2000 due to effective DSZ strategies, including plasma exchange, LIT, splenectomy, and rituximab, and success is now similar to that of ABO-C LT [3,4]. LIT was first introduced by the Keio and Kyoto groups with the aim of preventing local intravascular coagulation in the liver by direct infusion of anti-inflammatory agents, such as steroids or prostacyclin, through the hepatic artery or portal vein, and resulted in improved survival rates in patients receiving ABO-I LDLT [10,11]. However, LIT does not prevent the fundamental antibody-mediated immunological reaction, and in fact has a negative impact on the outcome in ABO-I LDLT because it is associated with a higher incidence of catheter-related complications, such as vascular thrombosis, sepsis, bleeding, and catheter dislocation [2,7].…”

Remedy Experience of Severe Abdominal Infection after Orthotopic Liver Transplantation

“…After the patient achieved a stable condition, growth hormone was administered to improve body metabolism and immune status, protect the intestinal barrier function, and promote the recovery of the body. Better clinical results were achieved (13)(14)(15)(16)(17).…”

Current aspects of ABO-incompatible liver transplantation

“…Besides, biliary complications were transient and resolved completely. The second innovation was introduced by a Kyoto group of specialists [6]. The immunosuppressive therapy included multiple perioperative plasmapheresis, splenectomy, and treatment with tacrolimus, methylprednisolone, and cyclophosphamide.…”

“…Another local infusion therapy emerged from Kyoto group [6]. The immunosuppressive therapy included multiple perioperative plasmapheresis, splenectomy, and treatment with tacrolimus, …”