Successful Combined Treatment of Primary Cardiac Malignant Lymphoma With Urgent Cardiac Operation and Chemotherapy

Fujita, Yoshifumi; Inamori, Masahiko; Tarui, Suguru; Irié, Hiroyuki

doi:10.1253/circj.cj-08-0064

Cited by 15 publications

(6 citation statements)

References 7 publications

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“…Pathology-based diagnosis of malignant lymphoma is essential in order to administer appropriate therapy. Most PCLs in the literature were B-cell neoplasms and of the diffuse large cell type 1-4)7-9). Our patient was also diagnosed with diffuse large B cell lymphoma and this was confirmed by immunohistology.…”

Section: Discussionsupporting

confidence: 75%

A Butterfly-Shaped Primary Cardiac Lymphoma That Showed Bi-Atrial Involvement

et al. 2012

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We described here a patient who presented with symptoms of heart failure who was found to have severe bilateral impairment of atrioventricular inflow. Primary cardiac lymphoma (PCL) with extensive involvement of the two atria, pericardium and myocardium is an extremely rare tumor in immunocompetent patients. We report here a case of PCL in an immunocompetent patient with involvement of both atria and the atrial septum. The tumor had a butterfly shape. We could not do surgical excision because of the massive pericardiac invasion. The diagnosis was B-cell lymphoma and this was confirmed by the pericardiac biopsy.

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Section: Discussionsupporting

confidence: 75%

A Butterfly-Shaped Primary Cardiac Lymphoma That Showed Bi-Atrial Involvement

et al. 2012

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“…Primary cardiac lymphoma is an extremely type of lymphoma, the majority of which are of the B cell phenotype,2) as seen in the second case. Although there have been case reports and small case series of B cell lymphomas presenting as AV block,3)4) the first case is one of the first to demonstrate that T cell lymphomas can also present as such.…”

Section: Discussionmentioning

confidence: 86%

Multimodality Imaging Can Help to Doubt, Diagnose and Follow-Up Cardiac Mass

et al. 2011

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Primary cardiac lymphoma is a very rare form of lymphoma primarily or mainly involving the heart, as in the two cases presented in this report. Various imaging modalities, including coronary computed tomography angiography, cardiac magnetic resonance imaging and positron emission tomography were useful for the characterization and diagnosis of cardiac mass. Pathologic confirmation was successful with endomyocardial biopsy under echocardiographic guidance, intra- and extracardiacally. In primary cardiac lymphoma, diagnosis using multiple modalities may be useful for mass characterization, and for response monitoring after chemotherapy.

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“…In general, DLBCL is one of the most aggressive types of lymphoma and can progress extremely rapidly, as illustrated by a report of a patient with palpitations who had normal findings on echocardiography and examination by a cardiologist at 3 weeks prior to presenting with heart failure caused by an 8 cm mass in the right atrium and ventricle [ 14 ]. It is also well known that cardiac DLBCL can cause circulatory failure at an early stage [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is also well known that cardiac DLBCL can cause circulatory failure at an early stage [ 15 , 16 ]. There are a few published case reports of patients with acute right-sided heart failure who underwent emergency tumor excision by the Fontan procedure before successfully undergoing chemotherapy or who received chemotherapy with the support of arterio-venous extracorporeal membrane oxygenation (ECMO) [ 14 , 15 , 17 , 18 ]. Because invasive treatments such as surgical revascularization, tumor excision, and assisted circulation with ECMO must often be considered in patients with rapidly progressive cardiac failure, prompt diagnosis and swift decision-making about the appropriateness of such invasive procedures in an individual are essential.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Recurrence of Diffuse Large B-cell Lymphoma More Than a Decade After Attaining Complete Remission

et al. 2018

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Patient: Female, 79Final Diagnosis: Cardiac recurrence of DLBCLSymptoms: Cardiogenic shockMedication: —Clinical Procedure: Biopsy specimenSpecialty: Cardiology/HematologyObjective:Unusual clinical courseBackground:Although diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults, isolated cardiac recurrence of DLBCL which can cause fatal heart failure via various mechanisms is extremely rare. Furthermore, the frequency of recurrence of DLBCL more than 5 years after attaining complete remission is as low as 3.6%. The rate of complete remission and partial remission of DLBCL that have recurred 5 or more years after attaining the initial remission are reported to be 61% and 29%, respectively.Case Report:A 79-year-old female with a history of DLBCL at the age of 63 years was transferred to our hospital because of cardiogenic shock. Although cardiac tamponade was suspected, her hemodynamics did not improve with pericardiocentesis. Thoracotomy showed an elastic to hard tumor occupying most of the right ventricular wall. Cytological examination of the pericardial effusion and histological examination of a biopsy of the tumor yielded a diagnosis of DLBCL; this information was available only post mortem. Immunostaining of a biopsy specimen suggested that her cardiac tumor was a recurrence of her lymphoma diagnosed 16 years previously. Bone marrow aspiration was not performed; no recurrences were detected in any other site. This patient thus appeared to have an isolated cardiac recurrence of DLBCL.Conclusions:When managing a patient with a cardiac tumor and a past history of DLBCL, albeit more than a decade previously, establishing a histological diagnosis as early as possible would facilitate possible successful treatment and a good prognosis.

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Successful Combined Treatment of Primary Cardiac Malignant Lymphoma With Urgent Cardiac Operation and Chemotherapy

Cited by 15 publications

References 7 publications

A Butterfly-Shaped Primary Cardiac Lymphoma That Showed Bi-Atrial Involvement

A Butterfly-Shaped Primary Cardiac Lymphoma That Showed Bi-Atrial Involvement

Multimodality Imaging Can Help to Doubt, Diagnose and Follow-Up Cardiac Mass

Cardiac Recurrence of Diffuse Large B-cell Lymphoma More Than a Decade After Attaining Complete Remission

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