Successful desensitization to gonadotropin‐releasing hormone analogue triptorelin acetate using a sustained‐release depot preparation

Ng, Poh Lin Pauline Chan; Huang, Chiung‐Hui; Rajakulendran, Mohana; Tan, Michelle Meiling; Wang, Ping Ping; Tay, Lei Qiu; Goh, Siok Ying; Tham, Elizabeth Huiwen

doi:10.1111/pai.12927

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…If it is essential to use the GnRH that caused hypersensitivity reaction and alternative therapeutic options are not available, desensitization protocols can be used. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Hypersensitivity Reactions with Leuprolide Acetate and Triptorelin Acetate in Children

Misirlioglu¹,

Metbulut²,

Adıgüzel³

et al. 2021

Indian Journal of Endocrinology and Metabolism

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Introduction: Gonadotropin releasing hormone analogues (GnRHa) are commonly used to treat central precocious puberty (CPP). Generally, they are well-tolerated; however adverse reactions have been reported. Local adverse events occur in 10-15% of the patients who were treated with GnRHa. Anaphylactoid reactions with GnRHa are very rarely seen. The aim of this study is to report our clinical experience with hypersensitivity reactions seen in pediatric patients receiving leuprolide acetate (LA) and triptorelin acetate (TA) in CPP at the single pediatric tertiary medical center and to evaluate the incidence rate of hypersensitivity reactions. Methods: This retrospective study included children with CPP who were treated with GnRHa (LA and TA) at our hospital between January 2013 and December 2020. We analyzed clinical characteristics of patients who experienced adverse reactions and analyzed the incidence rate. Results: Seven side effects (adverse reactions) (0.69%) were observed among total of 1010 CPP patients who were treated with TA and LA. Sterile abscesses were observed in 3 patients (0.29%). None of the patients had an anaphylaxis. Tremors of both hands, a vomiting episode, an urticarial rash, and musculoskeletal stiffness were observed in one patient each. Conclusion: In our study, mild reactions were seen in 7 patients. GnRHa can be safely used and well-tolerated medications; but exceedingly rare, severe reactions can be developed.

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“…If it is essential to use the GnRH that caused hypersensitivity reaction and alternative therapeutic options are not available, desensitization protocols can be used. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Hypersensitivity Reactions with Leuprolide Acetate and Triptorelin Acetate in Children

Misirlioglu¹,

Metbulut²,

Adıgüzel³

et al. 2021

Indian Journal of Endocrinology and Metabolism

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“…Successful desensitization to gonadotropin‐releasing hormone analogue triptorelin acetate was reported using a sustained‐release depot preparation …”

Section: Drug Allergymentioning

confidence: 99%

Food and drug allergy, and anaphylaxis in EAACI journals (2018)

Eigenmann

Akdiş²,

Bousquet

et al. 2019

Pediatric Allergy Immunology

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: "Allergy," "Pediatric Allergy and Immunology (PAI)," and "Clinical and Translational Allergy (CTA)." One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. This paper summarizes the achievements of 2018 in anaphylaxis, and food and drug allergy. Main topics that have been focused are anaphylaxis, mechanisms of food allergy (FA), epidemiology of FA, food allergens, diagnosis of FA, prevention and control of FA, FA immunotherapy, drug allergy, and political agenda. K E Y W O R D S allergy, anaphylaxis, Clinical and Translational Allergy, drug allergy, European Academy of Allergy and Clinical Immunology, food allergy, hypersensitivity, Pediatric Allergy and Immunology

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“…Gonadotropin-releasing hormone (GnRH) analogs are widely utilized in pediatric patients as depot formulations to manage CPP 4 . These analogs work by suppressing gonadotropin and sex hormone secretion, thereby preventing the progression of advanced puberty and mitigating the impact on final adult height due to accelerated growth plate fusion 5 . One commonly used GnRH analog is triptorelin acetate (TA), a synthetic nanopeptide that downregulates GnRH receptors in the pituitary 2 .…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Analysis of Spontaneous Reports of Suspected Adverse Drug Reactions to Triptorelin Acetate in a Tertiary Pediatric Medical Center: Still a Lot of Preventable Harm

Cao,

Cheng,

Chen

et al. 2023

Preprint

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Background: Although triptorelin acetate (TA) is generally considered a safe medication, severe adverse drug reactions (ADRs) to triptorelin have occurred. In this study, we present the largest retrospective analysis of ADRs related to TA during the treatment of pediatric central precocious puberty. Methods: We describe a total of 38 suspected cases of TA-induced ADRs reported to the pharma-covigilance center of Shenzhen Children’s Hospital from September 2015 to December 2022. Causality assessment was carried out using the validated Kramer’s algorithm. The severity of ADRs was evaluated using the Modified Hartwig and Siegel Scale. Results: The most common ADRs attributed to TA were damage to the cutaneous tissues (29.3%) and reactions affecting the systemic and digestive systems (20.7%). The majority (61.1%) of ADRs occurred within 2 hours of administration. Among the 12 patients with severe ADRs, the three most frequent symptoms were anaphylactic reactions, hip synovitis, and arthralgia. Additional-ly, six patients experienced ADRs due to a change in the manufacturing process. Conclusion: The majority of ADRs observed in pediatric cases were type I anaphylactic reactions, which are rare but life-threatening. It is advisable to perform skin prick tests and intradermal tests when switching pharmaceutical manufacturers.

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Successful desensitization to gonadotropin‐releasing hormone analogue triptorelin acetate using a sustained‐release depot preparation

Cited by 6 publications

References 10 publications

Evaluation of Hypersensitivity Reactions with Leuprolide Acetate and Triptorelin Acetate in Children

Evaluation of Hypersensitivity Reactions with Leuprolide Acetate and Triptorelin Acetate in Children

Food and drug allergy, and anaphylaxis in EAACI journals (2018)

A Retrospective Analysis of Spontaneous Reports of Suspected Adverse Drug Reactions to Triptorelin Acetate in a Tertiary Pediatric Medical Center: Still a Lot of Preventable Harm

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