Successful Diagnosis of Gallbladder Carcinoma Coexisting with Adenomyomatosis by 18F-FDG-PET—Report of a Case

Suzuki, Keiichi; Watada, Susumu; Mitsui, Yoko; Nakahara, Tsutomu; Kumamoto, Yusuke

doi:10.1007/s12029-010-9221-5

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…13 In these cases FDG PET is recommended after reduction of the serum level of C-reactive protein. 14 According to treatment algorithm developed by Pellino et al symptomatic patients with GBA should undergo surgery. In asymptomatic patients management depends on the different GBA types.…”

Section: Resultsmentioning

confidence: 99%

Segmental type of gallbladder adenomyomatosis – Case report and literature review

Michalak

Milewski

Żurada

et al. 2015

Polish Annals of Medicine

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Section: Resultsmentioning

confidence: 99%

Segmental type of gallbladder adenomyomatosis – Case report and literature review

Michalak

Milewski

Żurada

et al. 2015

Polish Annals of Medicine

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“…However, sometimes FDG uptake occurs only in gallbladder lesions. Because benign gallbladder lesions, such as cholecystitis [ 29 ], adenomyomatosis [ 30 ] and gallbladder polyps [ 31 ], also have FDG uptake, when this occurs, the diagnosis is often controversial. The uptake of adenomyomatosis and gallbladder polyps is often lower than that of the liver parenchyma; thus, it is easier to differentiate from GBC [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Multiparameter diagnostic model based on 18F-FDG PET metabolic parameters and clinical variables can differentiate nonmetastatic gallbladder cancer and cholecystitis

Luan

et al. 2023

BMC Cancer

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Objective To evaluate the diagnostic value of a multiparameter model based on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) metabolic parameters and clinical variables in differentiating nonmetastatic gallbladder cancer (GBC) from cholecystitis. Patients and methods In total, 122 patients (88 GBC nonmetastatic patients and 34 cholecystitis patients) with gallbladder space-occupying lesions who underwent 18F-FDG PET/CT were included. All patients received surgery and pathology, and baseline characteristics and clinical data were also collected. The metabolic parameters of 18F-FDG PET, including SUVmax (maximum standard uptake value), SUVmean (mean standard uptake value), SUVpeak (peak standard uptake value), MTV (metabolic tumour volume), TLG (total lesion glycolysis) and SUVR (tumour-to-normal liver standard uptake value ratio), were evaluated. The differential diagnostic efficacy of each independent parameter and multiparameter combination model was evaluated using the receiver operating characteristic (ROC) curve. The improvement in diagnostic efficacy using a combination of the above multiple parameters was evaluated by integrated discriminatory improvement (IDI), net reclassification improvement (NRI) and bootstrap test. Decision curve analysis (DCA) was used to evaluate clinical efficacy. Results The ROC curve showed that SUVR had the highest diagnostic ability among the 18F-FDG PET metabolic parameters (area under the curve [AUC] = 0.698; sensitivity = 0.341; specificity = 0.971; positive predictive value [PPV] = 0.968; negative predictive value [NPV] = 0.363). The combined diagnostic model of cholecystolithiasis, fever, CEA > 5 ng/ml and SUVR showed an AUC of 0.899 (sensitivity = 0.909, specificity = 0.735, PPV = 0.899, NPV = 0.758). The diagnostic efficiency of the model was improved significantly compared with SUVR. The clinical efficacy of the model was confirmed by DCA. Conclusions The multiparameter diagnostic model composed of 18F-FDG PET metabolic parameters (SUVR) and clinical variables, including patient signs (fever), medical history (cholecystolithiasis) and laboratory examination (CEA > 5 ng/ml), has good diagnostic efficacy in the differential diagnosis of nonmetastatic GBC and cholecystitis.

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“…Recently, we also reported a resected case of GBC coexisting with ADM, which was successfully diagnosed preoperatively by FDG-PET/CT. 20 Segmental ADM occurring in the gallbladder fundic mucosa is considered a precancerous condition, and the type of ADM appears to be important for GBC development. Ootani et al 6 reported that GBC developed in 6.4% (12/279 cases) of patients with segmental ADM, whereas no clear association was found between localized and generalized ADM and GBC.…”

Section: Discussionmentioning

confidence: 99%

A Resected Gallbladder Carcinoma Coexisting With Adenomyomatosis Involving Varied Degrees of Intraepithelial Dysplasia: A Case Report and Literature Review

Suzuki

Abe

Ohbu

2019

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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A 59-year-old asymptomatic man underwent ultrasonography, which revealed gallstones and thickened gallbladder wall. Abdominal computed tomography (CT) showed a slightly swollen bilocular gallbladder and a soft tissue mass in the fundus site. Segmental adenomyomatosis (ADM) was suspected because numerous fundic cystic lesions were seen on magnetic resonance imaging. Endoscopic ultrasonography revealed numerous Rokitansky-Aschoff sinuses (RAS) and a papillary

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Successful Diagnosis of Gallbladder Carcinoma Coexisting with Adenomyomatosis by 18F-FDG-PET—Report of a Case

Cited by 10 publications

References 22 publications

Segmental type of gallbladder adenomyomatosis – Case report and literature review

Segmental type of gallbladder adenomyomatosis – Case report and literature review

Multiparameter diagnostic model based on 18F-FDG PET metabolic parameters and clinical variables can differentiate nonmetastatic gallbladder cancer and cholecystitis

A Resected Gallbladder Carcinoma Coexisting With Adenomyomatosis Involving Varied Degrees of Intraepithelial Dysplasia: A Case Report and Literature Review

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