Successful Eradication of Helicobacter pylori as Determined by 13C-Urea Breath Test Does Not Alter Fibrinogen and Acute Phase Response Markers

Schweeger, Ingrid; Fitscha, P; Sinzinger, H.

doi:10.1016/s0049-3848(99)00230-3

Cited by 18 publications

(13 citation statements)

References 32 publications

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“…Notably, no difference in number of WBC between H pylori-infected patients with gastritis and those with ulcer has been noted [21] . Additionally, little difference has been reported in number of WBC between those with active disease and those with inactive disease in patients with inflammatory bowel disease [22] .…”

Section: Discussionmentioning

confidence: 99%

Clinical investigation of 41 patients with ischemic colitis accompanied by ulcer

Matsumoto¹,

Tsuji²,

Shirahama³

2007

WJG

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AIM: To investigate the relationship among the presence of ulcer lesions, underlying disease, and clinical course in patients with ischemic colitis. METHODS:The subjects were 41 patients (10 male and 31 female; mean age 70 years) with ischemic colitis who were admitted to and received treatment in our hospital from 2000 to 2006. We compared their characteristics and analyzed the mean lengths of admission and fasting for 9 patients with ulcer lesions (ulcer group) and 32 without (non-ulcer group). RESULTS:The groups with presence and absence of ulcer differed significantly only in white blood cell (WBC) count. Lengths of fasting and admission were 7.9 d and 17.9 d for the ulcer group and 4.4 d and 10.7 d for the non-ulcer group, respectively, and significantly longer in the ulcer group (P = 0.0057 and 0.0001). There was no correlation between presence of ulcer and presence of underlying diseases. CONCLUSION:Lengths of fasting and admission were significantly longer in patients with ischemic colitis with ulcer than for those without ulcer.

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Section: Discussionmentioning

confidence: 99%

Clinical investigation of 41 patients with ischemic colitis accompanied by ulcer

Matsumoto¹,

Tsuji²,

Shirahama³

2007

WJG

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“…However, the role of H. Pylori in the pathogenesis of atherosclerosis is controversial and the mechanism in this association is also unclear. Several different mechanisms are proposed for the role of H. pylori in ischemic heart disease [1–4, 9, 10, 24]. …”

Section: Discussionmentioning

confidence: 99%

Helicobacter pyloriEradication Lowers Serum Asymmetric Dimethylarginine Levels

Aydemır

Eren

Tekin

et al. 2010

Mediators of Inflammation

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Introduction. Microbial pathogens, one of them is Helicobacter pylori (H. pylori), have frequently been implicated in the atherogenesis. Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS) and plays a pivotal role in the regulation of vascular tone. Asymmetric dimethylarginine (ADMA) is the most potent endogenous NOS inhibitor. Elevated levels of ADMA have been reported in many circumstances associated with a high cardiovascular risk. The aim of the present study was to investigate whether the eradication of H. pylori infection affects serum ADMA levels. Materials and Methods. Forty-two H. pylori-positive patients were enrolled in the study. Triple therapy for 14 days were given to all patients. Serum ADMA levels were measured at baseline and 2 months after therapy. Results. Eradication was achieved in 34 (81%) patients. The mean serum ADMA levels before and after therapy were 1, 77 ± 0, 30 and 1, 67 ± 0, 29 ng/mL in the group with H. pylori eradicated and 1, 63 ± 0, 28 and 1, 56 ± 0, 32 ng/mL in the noneradicated, respectively. We detected statistically significant decreased serum ADMA levels after therapy in H. pylori eradicated group. Conclusion. These findings have indicated that eradication of H. pylori infection may decrease the risk of atherosclerosis and cardiovascular events.

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“…These observations raise the possibility that chronic infections may be CHD risk factors mostly or only in these "susceptible" individuals who react to these infections with a harmful systemic inflammatory reaction, reflected in elevated levels of CRP. Treating Helicobacter pylori and Chlamydia pneumoniae infections decreased CRP levels in the study of Torgano et al [4] but no effect was observed in the study of Schweeger et al [5]. …”

Section: Introductionmentioning

confidence: 99%