Successful eradication of Helicobacter pylori with a herbal medicine, goshuyuto (Wu Zhu Yu Tang), plus rabeprazole after failure of triplet therapy with vonoprazan: A report of three cases

Nagata, Yutaka; Nagasaka, Kazuhiko; Koyama, Syunpei; Murase, Masatoshi; Saito, Minoru; Yazaki, Toshinori; Komatsu, Nobutoshi; Murase, Takayuki; Uehara, Toshiki; Taniuchi, Norihide

doi:10.1111/1751-2980.12537

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…(2017) in China indicated the effectiveness of goshuyuto and the successful eradication of a resistant species of H. pylori infection with this medicinal plant compared to drug regimens [31]. Besides, Hajiagha mohammadi et al (2015) in Qazvin stated that adding garlic extract to the standard anti-H. pylori regimen increased its eradication rate from 52.6-75.8% [21].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, due to the lack of a cost-effectiveness threshold in Iran and as proposed by the World Health Organization (WHO), the threshold of one to three times the per capita GDP was considered for developing countries [30]. The GDP in Iran was $ 12547 in 2019 (1* GDP) [31], using which the threshold of willingness to pay (WTP) was $ 37641 (3* GDP) in the country [32].…”

Section: Sensitivity Analysismentioning

confidence: 99%

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Cost-Effectiveness Analysis Of Plant Versus Antibiotic Regimens In Treating Patients With Helicobacter Pylori (H. Pylori) Infection In The South Of Iran

Faramarzi

Khajoei

Lotfi

et al. 2022

Preprint

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Background: Helicobacter pylori infection is highly prevalent worldwide and affects more than half of the world's population. A variety of treatment regimens to eliminate H. pylori infection have been evaluated, but choosing the best treatment method that results in the most eradication at the lowest cost is one of the challenges facing physicians. Therefore, the present study aimed at analyzing the cost-effectiveness of using different methods to treat H. pylori in southern Iran. Methods: This study was a cost-effectiveness analysis conducted on 132 patients with H. pylori who referred to Shahid Motahari Clinic in Shiraz. The study was carried out in 2020 to evaluate two drug treatment strategies, including antibiotics (pantoprazole 40 mg, Bismuth subcitrate 108 mg, tetracycline 500 mg, and metronidazole 200 and 400 mg) and plants (Supermint Barij soft capsules 20 mg, Alium S garlic tablets 400 mg, and Green Teadin (green tea) tablets 500 mg). The patients were randomly divided into two groups, 64 of whom received an antibiotic regimen and 68 patients given a plant regimen. The success rate of clinical trials in each treatment method was determined as the clinical outcome. This study was conducted from a community perspective and therefore, direct and indirect costs were included. A data collection form was also used to collect the cost and effectiveness data. In addition, a one-way sensitivity analysis was performed to measure the robustness of the results. The data were analyzed using TreeAge Pro 2011 and Excel 2016 software. Results: The results showed that antibiotic treatment was cheaper and more effective than plant treatment and was the dominant strategy. The mean costs in the antibiotics and plant groups were $446.14 and $477.81, respectively, and the effectiveness was 0.625% and 0.382%. In addition, the one-way sensitivity analysis confirmed the robustness of the study results. Conclusion: The results showed that the use of antibiotics was a cost-effective and dominant strategy compared to plant treatment and could be suggested as a better alternative to a wide range of patients with Helicobacter pylori infection.

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Section: Discussionmentioning

confidence: 99%

Section: Sensitivity Analysismentioning

confidence: 99%

Cost-Effectiveness Analysis Of Plant Versus Antibiotic Regimens In Treating Patients With Helicobacter Pylori (H. Pylori) Infection In The South Of Iran

Faramarzi

Khajoei

Lotfi

et al. 2022

Preprint

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show abstract

“…Chang et al found that geniposide, a bioactive extract of Gardenia, could obviously reduce H. pylori infections by interfering with the growth and virulence as well as attenuating the inflammatory response [18]. Nagata et al reported that successful eradication of H. pylori with a herbal medicine, goshuyuto (Wu Zhu Yu Tang), prevents relapse of peptic ulcer disease [19]. Therefore, it is expected that herbal products may be promising drugs against H. pylori infection and may be able to decrease the risk of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Effect of Celastrus orbiculatus in inhibiting Helicobacter pylori induced inflammatory response by regulating epithelial mesenchymal transition and targeting miR-21/PDCD4 signaling pathway in gastric epithelial cells

Zhu¹,

Liu

et al. 2019

BMC Complement Altern Med

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Background The extract of Celastrus orbiculatus (COE) have been studied for anti- Helicobacter pylori ( H. pylori ) activity and anti-cancer effects in vitro and in vivo. However, the molecular mechanism by which COE inhibits H. pylori -induced inflammatory response has not been fully elucidated so far. Methods The effects of COE on viability, morphological changes, inflammatory cytokine secretion, protein and mRNA expression were analyzed by MTT assay, enzyme-linked immunosorbent assay (ELISA), immunofluorescence, western blot and real-time PCR (RT-PCR), respectively. The methylation level of programmed cell death 4 (PDCD4) promoter was investigated by methylation-specific PCR. (MSP) . Results COE effectively inhibited the H.pylori -induced inflammatory response by regulating epithelial-mesenchymal transition (EMT). The methylation level of PDCD4 promoter was suppressed by COE, which increased the expression ofPDCD4. Moreover, COE could inhibit microRNA-21 (miR-21) expression, as shown by an enhancement of its target gene PDCD4. Furthermore, both miR-21 over-expression and PDCD4 silencing attenuated the anti-inflammatory effect. of COE. Conclusions COE inhibits H. pylori induced inflammatory response through regulating EMT, correlating with inhibition of miR-21/PDCD4 signal pathways in gastric epithelial cells. Electronic supplementary material The online version of this article (10.1186/s12906-019-2504-x) contains supplementary material, which is available to authorized users.

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“…A Chinese meta-analysis revealed that integrated traditional Chinese and Western medicine treatment had a higher eradication rate and fewer adverse reactions than Western medicine alone (OR 2.21, 95% CI: 1.74, 2.81) ( Zhong et al, 2022 ). Other studies demonstrated that the combination of berberine or WUZHUYUTANG combined with the antibiotic bismuth can improve the eradication effect of rescue treatment ( Nagata et al, 2018 ; Zhang et al, 2020 ). However, these studies were only conducted in China, and more Western studies are needed to confirm whether this treatment is suitable for patients in other parts of the world.…”

Section: Options For Rescue Treatment: Antibiotic-susceptibility Test...mentioning

confidence: 99%

Treatment of refractory Helicobacter pylori infection: A new challenge for clinicians

He²,

Zhu³

2022

Front. Microbiol.

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Patients who have failed two or more attempts to eradicate Helicobacter pylori are commonly referred to as refractory. Although the incidence of refractory Helicobacter pylori infection is only 10–20%, with the increasing rate of antibiotic resistance in various regions, the treatment of refractory Helicobacter pylori infection has gradually become a difficult problem faced by clinicians. When choosing a rescue therapy, the physician must consider numerous factors. A longer treatment duration, higher doses of proton pump inhibitors (PPIs), or the use of potassium-competitive acid blocker (P-CAB) may increase the efficacy of triple therapy or bismuth quadruple therapy. Rescue treatment based on bismuth quadruple therapy usually achieves better results. At the same time, treatment based on drug susceptibility tests or genotypic resistance is recommended where available. Of course, appropriate empiric treatment can also be selected according to local drug resistance, a patient’s previous medication history and compliance. It is the best choice if it can improve the success rate of the first treatment and reduce the occurrence of refractory Helicobacter pylori infection. This review aims to summarize the articles related to refractory Helicobacter pylori in recent years and to explore a better remedial treatment plan for clinicians.

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Successful eradication of Helicobacter pylori with a herbal medicine, goshuyuto (Wu Zhu Yu Tang), plus rabeprazole after failure of triplet therapy with vonoprazan: A report of three cases

Cited by 5 publications

References 9 publications

Cost-Effectiveness Analysis Of Plant Versus Antibiotic Regimens In Treating Patients With Helicobacter Pylori (H. Pylori) Infection In The South Of Iran

Cost-Effectiveness Analysis Of Plant Versus Antibiotic Regimens In Treating Patients With Helicobacter Pylori (H. Pylori) Infection In The South Of Iran

Effect of Celastrus orbiculatus in inhibiting Helicobacter pylori induced inflammatory response by regulating epithelial mesenchymal transition and targeting miR-21/PDCD4 signaling pathway in gastric epithelial cells

Treatment of refractory Helicobacter pylori infection: A new challenge for clinicians

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