No abstract

We report four cases of anxiety disorder where psychiatric symptoms were effectively treated with combination therapy utilizing keishikaryukotsuboreito and kanbakutaisoto, which are two herbal formulas. The patients had common symptoms and experienced episodes leading to emotional stress. Moreover, in all four cases aggravation of psychiatric symptoms due to emotional stress, re-experience and memory retrieval were commonly observed. Additional treatment with kanbakutaisoto was effective for such aggravation. On the objective assessment, rapid pulse, deficient pulse, weak abdominal strength and brisk pulsation in the supraumbilical region were present. Yawning was not necessarily present. There are many patients with anxiety disorder or mental disorder associated with emotional stress, and Kampo treatment is often considered to be effective for these cases. However, a single administration of Kampo extract formulae does not often provide adequate results. When a single Kampo administration is ineffective, the combination of keishikaryukotsuboreito and kanbakutaisoto may be useful.keishikaryukotsuboreito, kanbakutaisoto, keishikaryukotsuboreitogokanbakutaisoto, anxiety disorder

Case: We present the case of a 43-year-old woman diagnosed with antibiotic-associated diarrhea. She had diarrheal and hemorrhagic stool after secondary eradication of Helicobacter pylori. On examination of feces, rapid test for Clostridium difficile was glutamate dehydrogenase (GDH) antigen positive/toxins negative. Vancomycin was initiated for the C. difficile infection due to intolerance (nausea) of metronidazole, but vancomycin treatment was a clinical failure. GDH screening test continued to be positive. Kampo treatment was requested and daiobotampito (DBT) was selected due to eligible right lower quadrant abdominal pain. Stool abnormality improved and the GDH test became negative after DBT treatment. Outcome: Symptoms such as diarrheal and hemorrhagic stool improved after treatment with DBT. Conclusion: DBT may be useful for antibiotic-associated diarrhea non-responsive to antibiotics.