Successful human ovarian autotransplantation to the upper arm

Hilders, Carina G. J. M.; Barański, Andrzej; Peters, Lex; Ramkhelawan, Andre; Trimbos, J. Baptist

doi:10.1002/cncr.20715

Cited by 77 publications

(48 citation statements)

References 96 publications

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“…This leads to a substantial loss of follicles in cryopreserved ovarian tissue, which is estimated to be at least 50% to 75% [31][32][33]. Ischemia and hypoxia, which are the critical factors in follicular loss, are the major limiting factors that have been shown to affect the longevity of the graft [19,32]. In this case, a follow-up period of transplanted ovarian cortical pieces for 21 months demonstrated adequate ovarian endocrine function including vascularization and follicular activity.…”

Section: Resultsmentioning

confidence: 80%

“…Neovascularization from the surrounding tissue will take ≤ 5 months before the initiation of follicular activity and hormone production [29]. This leads to a substantial loss of follicles in cryopreserved ovarian tissue, which is estimated to be at least 50% to 75% [31][32][33]. Ischemia and hypoxia, which are the critical factors in follicular loss, are the major limiting factors that have been shown to affect the longevity of the graft [19,32].…”

Section: Resultsmentioning

confidence: 99%

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Autologous Transplantation of Cryopreserved Ovarian Tissue to the Upper Extremity for the Preservation of Ovarian Function in Young Patient with Cervical Carcinoma

Chen¹,

Shao²,

Ma³

et al. 2017

J Cancer Sci Ther

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For women of reproductive age with cervical carcinoma, they usually receive not only standard surgical treatment but also postoperative radiotherapy to increase the cure rates. However, infertility and premature ovarian failure are often occurred after radiotherapy. Autotransplantation of cryopreserved ovarian tissue is a new technique for preserving gonadal function for cervical cancer patients of reproductive age. Here, a successful ovarian function recovery through cryopreservation and autotransplantation in a case of 28-year-old patient with cervical cancer was reported. In brief, a slow-programmed freezing/thawing method was conducted for ovarian cortex cryopreservation. Six thawed ovarian cortical slices were transplanted to the left upper arm after the radiotherapy. The ovarian endocrine functions and follicle growth was successfully improved to normal level at 12 months after autotransplantation. In conclusion, autotransplantation of cryopreserved ovarian cortex for ovarian function preservation is a viable option for cervical cancer patients to gain the quality of life and avoid the suffering from conventional menopause hormone therapy.[17,18]. Therefore, this study chose slow-freezing for cryopreservation of ovarian tissue.In this study, we reported a successful experience of the ovarian function recovery after radiotherapy using slow freezing/thawing method for ovarian cortex cryopreservation in a 28-year-old cervical cancer patient. Several parameters such as follicle development, level of serum estrogen 2 (E 2 ), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) after transplantation were observed and recorded for evaluating the recovery of ovarian function in a follow-up of 21 months. Materials and Methods Patient recruitmentA 28-year-old woman with cervical cancer was referred to the Department of Gynecology at the Shenzhen People's Hospital in June 2013. Her weight was 49.5 kg and the blood pressure was 92/60 mmHg at the time of determination. Her medical history revealed 1 uncomplicated pregnancy. She had irregular post-coital bleeding without the use of oral contraceptives during the last year. During the last 2 months, she had symptoms of irregular vaginal blood loss and menstruation endless dripping. MRI examination showed a cervical

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Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Autologous Transplantation of Cryopreserved Ovarian Tissue to the Upper Extremity for the Preservation of Ovarian Function in Young Patient with Cervical Carcinoma

Chen¹,

Shao²,

Ma³

et al. 2017

J Cancer Sci Ther

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“…e appreciate the comments of K. Oktay on our article, 1 and the opportunity to further explain our opinion on the subject of fertility preservation.…”

mentioning

confidence: 88%

Successful human ovarian autotransplantation to the upper arm

Oktay

2005

Cancer

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“…The fertilized eggs were placed in the uterus of three female monkeys, one of which gave birth to a baby. Application of this technique to humans will enable preservation of fertility in patients on radiotherapy for breast or uterine cancer by transplanting the ovary to a site other than the areas of irradiation 4,5) . In mammals, there is a report of autotransplantation of whole cryopreserved ovine ovaries resulting in a live birth 6) .…”

Section: Animal Experimentsmentioning

confidence: 99%

Super-Microsurgery for vascularized ovarian transplantation

Ong

Nakagawa

Noguchi

et al. 2009

ACSC

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Chemotherapy and radiotherapy are essential in the treatment of cancers in children and young women. These therapies almost inevitably result in side effects of reduced ovarian function, specifi cally, premature ovarian failure and sterility. 1,2) So far, healthcare professionals have devoted their attention to cancer treatment and have not been concerned about these side effects. As times change, physicians have advocated the need to choose treatment based on the opinions of patients. In other words, patients have expressed their increasingly strong desire to preserve ovarian function, especially fertility, in addition to conventional therapies for cancer. Eventually, healthcare professionals must decide to work seriously in fi nding solutions to the demand to preserve ovarian functions while maintaining the outcomes of cancer treatment. Studies on preservation of the ovariesRecently, gynecological research has addressed the cryopreservation of sperm and eggs before initiation of cancer treatment to avoid iatrogenic sterility, a complication of cancer treatment. However, cryopreservation of eggs is possible only for postpubertal women and yields a very low rate (about 0.2%) of pregnancy after transplantation of cryopreserved eggs due to the structurally lower tolerance of eggs to freezing compared with sperm and fertilized eggs. In addition, placement of fertilized eggs and the embryo transfer requires a partner. Thus, attempts are ongoing to cryopreserve and transplant ovarian tissue.

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Successful human ovarian autotransplantation to the upper arm

Cited by 77 publications

References 96 publications

Autologous Transplantation of Cryopreserved Ovarian Tissue to the Upper Extremity for the Preservation of Ovarian Function in Young Patient with Cervical Carcinoma

Autologous Transplantation of Cryopreserved Ovarian Tissue to the Upper Extremity for the Preservation of Ovarian Function in Young Patient with Cervical Carcinoma

Successful human ovarian autotransplantation to the upper arm

Super-Microsurgery for vascularized ovarian transplantation

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