Successful Lymph Node Transplantation in Rats, With Restoration of Lymphatic Function

Surgical Treatment Modalities for Lymphedema

“…In a meta-analysis that pooled 5 studies, all patients reported subjective improvement, while 90.7% of patients had quantitative improvement, and 78.0% of patients were able to discontinue compressive therapy [7,12]. A randomized control trial also evaluated the efficacy of VLNT in treating stage II breast cancer-related lymphedema.…”

“…Through both in vitro and animal studies, 9-cis RA has been shown to effectively stimulate lymphangiogenesis and prevent lymphedema progression after combined radiation and surgical injury, as measured by clinical and standard histologic parameters [12].…”

Radiologic Manifestations of Senile Lymph Nodes in the Popliteal Fossa

“…[24][25][26] Based on results from these experiments, preliminary trials of lymph node transplantation have been attempted clinically for treating lymphedema of the upper extremities. 27,28 Procedures have included a vascularized groin free flap containing superficial inguinal lymph nodes that was harvested from the inguinal region and transferred to a recipient site (axillary, elbow, or wrist) on the affected limb for restoring lymphatic drainage function.…”

Vascularized Lymph Node Transfer

“…11 When the groin lymph node flap was transferred to the lymphadenectomized popliteal fossa as either an island flap or a free flap, it survived and reintegrated into the lymphatic circulation. However, when the vascular pedicle was divided and the tissue transferred as a graft, it did not survive.…”