Successful management of acute interstitial nephritis in two cases of disseminated tuberculosis

Kizilbash, Quratulain

doi:10.1016/j.tube.2016.09.014

Cited by 4 publications

(12 citation statements)

References 4 publications

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“…Our findings also provide a basis for patient management, particularly in female patients, who develop hematological toxicity during TB therapy. The current study also evaluated other ADRs, including hyperbilirubinemia, AKI, and CKD, which were not fully understood in a few previous studies . AKI and CKD caused by ATDs are rare but severe and have been reported concomitant with hepatitis in 10% of patients .…”

Section: Discussionmentioning

confidence: 99%

Antituberculosis Drug‐Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors

Zhang

Bai

et al. 2017

Clin Pharma and Therapeutics

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Antituberculosis drug‐induced adverse drug reactions (ATD‐ADRs) are increasing globally, and it is key to identify candidate ATD‐ADRs loci for clinical management. We prospectively enrolled 1,235 highly suspicious tuberculosis (TB) inpatients to investigate the profiles and genetic risk factors of ATD‐ADRs in the liver, kidneys, and blood. Overall, 644 subjects were eligible and genotyped for seven polymorphisms in drug‐metabolizing enzymes and transporter genes. Clinical follow‐up and blood analysis were performed regularly. We found that a notable rate of ATD‐ADRs (incidence: 16.5%, drug intervention rate: 10.4%), mainly involving hepatotoxicity (10.6%) and leukopenia (3.3%) in western China. CYP2D6 rs1135840 and NUDT15 rs116855232 increased the risks of hepatotoxicity and leukopenia with an odds ratio of 2.52 and 4.97, respectively. Both variants showed excellent negative predictive values (93.7% and 98.1%, respectively) but moderate sensitivities (72.7% and 52.4%, respectively). These data provide new insight into ATD‐ADRs in the Chinese population and may offer future leads for diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Antituberculosis Drug‐Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors

Zhang

Bai

et al. 2017

Clin Pharma and Therapeutics

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“…1 The kidney biopsy is the gold standard for the diagnosis of ATIN. 5 In cases where renal biopsy is contraindicated or not feasible, The diagnosis can be based on a compatible clinical course and laboratory findings. such as eosinophiluria and accumulation of 67 Ga in the bilateral kidneys.…”

Section: Discussionmentioning

confidence: 99%

“…When a biopsy is performed, ATIN and acute tubular necrosis are the most common histopathological findings during RIF‐induced AKI 1 . The kidney biopsy is the gold standard for the diagnosis of ATIN 5 …”

Section: Discussionmentioning

confidence: 99%

Rifampicin‐induced acute tubulointerstitial nephritis during pulmonary tuberculosis treatment: A case report

Moussa,

Esbaa,

Rouis

et al. 2023

Respirology Case Reports

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Drug‐induced tubulointerstitial nephritis is an uncommon complication in patients on anti‐tuberculosis therapy that can lead to permanent kidney damage. Rifampicin is the most offending drug. We report a case of a 41‐years old man being treated for pulmonary tuberculosis and presenting with tubulointerstitial nephritis associated with rifampicin. We focus on diagnosis features and therapeutic challenges.

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“…Entre los microorganismos relacionados con la presencia de la NTIA se destacan: la Legionella, Leptospira, cytomegalovirus (CMV), Streptococcus, Mycobacterium tuberculosis, Corynebacterium diphtheriae, virus de Epstein-Barr (EBV), Yersinia, Polyomavirus, Enterococcus, Escherichia coli, adenovirus, virus BK y Candida. Los pacientes infectados por VIH son particularmente susceptibles al desarrollo de las enfermedades de hipersensibilidad renal, no solo por el compromiso infeccioso derivado directamente por el genoma viral, sino por las coinfecciones y el uso constante de diferentes medicamentos (antiretrovirales, antimicrobianos y medicamentos antituberculosos) (3,12,32,33) . En un estudio en donde se revisaron 262 biopsias renales de pacientes con VIH, se encontró que cerca del 11 % de ellos presentaron la NTIA sin compromiso de la función renal; de estos, en el 72 % la causa de la NTIA fue asociada con medicamentos, especialmente, AINES y trimetoprim sulfametoxazol (32) .…”

Section: Ntia Por Infeccionesunclassified

“…La nefritis tubulointersticial aguda (NTIA) es un tipo de lesión renal que afecta típicamente el intersticio y se acompaña, generalmente, de daño tubular (1) . Se caracteriza por un infiltrado inflamatorio en el intersticio del riñón asociado a un deterioro de la función renal (2,3) .…”

Section: Introductionunclassified

Nefritis tubulointersticial aguda. Revisión bibliográfica

Nieto-Ríos

Ruiz-Velásquez

Álvarez

et al. 2020

Iatreia

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La nefritis tubulointersticial aguda hace referencia a un tipo de daño renal que afecta principalmente el intersticio y ocasiona la lesión renal aguda, potencialmente reversible. Su curso puede ser subclínico, con deterioro progresivo hasta evolucionar hacia la insuficiencia renal crónica. La nefritis tubulointersticial aguda tiene múltiples etiologías, las más frecuentes son los medicamentos, productos herbales, las infecciones y las enfermedades autoinmunes. Las principales manifestaciones clínicas son la poliuria, polaquiuria, nocturia, dolor lumbar, microhematuria y leucocituria, aunque puede ser totalmente asintomática. El tratamiento depende de la causa de base y los esteroides juegan un papel importante cuando la condición es de origen medicamentoso o autoinmune. El pronóstico generalmente es bueno, si el problema se identifica de forma oportuna y se trata adecuadamente.

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Successful management of acute interstitial nephritis in two cases of disseminated tuberculosis

Cited by 4 publications

References 4 publications

Antituberculosis Drug‐Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors

Antituberculosis Drug‐Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors

Rifampicin‐induced acute tubulointerstitial nephritis during pulmonary tuberculosis treatment: A case report

Nefritis tubulointersticial aguda. Revisión bibliográfica

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