Successful management of dowling-degos disease with combination of Q-switched Nd: YAG and fractional carbon dioxide laser

També, Swagata; Patil, Priyanka; Saple, D. G.

doi:10.4103/0974-2077.204583

Cited by 10 publications

(11 citation statements)

References 5 publications

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“…Retinoids have proved ineffective in DDD, and Er:YAG and fractional CO 2 are being considered to decrease pigmentation in DDD. [ 12 ] Our patients presented with predominantly comedones; therefore, oral isotretinoin was initiated, and the patients are being followed up to assess long-term safety. To conclude, presence of follicular papules, comedones, and pitted scars along with classical irregular star-shaped/Chinese letter pattern on dermoscopy are diagnostic clues for follicular DDD.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopy of follicular dowling–degos disease

et al. 2020

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Dowling–Degos disease (DDD) is a late-onset genodermatosis characterized by hyperpigmented macules on the flexures along with scattered comedo-like lesions and pitted acneiform scars. Follicular Dowling–Degos is a rare type of DDD, with only two reports so far. It presents with follicular papules and comedo-like lesions predominantly on the face and trunk. Dermoscopy of follicular DDD shows irregular star-shaped/Chinese letter pattern pigmentation along with comedo-like lesions. Herein, we describe diagnostic clues including dermoscopy in three patients of follicular DDD which can help in differentiating it from other disorders presenting with comedo-like lesions.

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Section: Discussionmentioning

confidence: 99%

Dermoscopy of follicular dowling–degos disease

et al. 2020

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“…Dowling‐Degos disease is an uncommon genodermatosis, and less than 100 cases have been reported in the literature. Both sexes are affected, with few sources reporting a slight female predominance 6,7 . There is no racial predilection for DDD 8 .…”

Section: Epidemiologymentioning

confidence: 99%

“…One report attempted treatment of a patient with DDD using three sessions of Q‑switched Nd: YAG laser 3 weeks apart followed by two sessions of fractional CO 2 laser 4 weeks apart. This resulted in significant improvement in the clinical hyperpigmentation as well as the pitted scarring 7 . One study performed both fractional ablative CO 2 laser therapy and fully ablative Er:YAG laser on the same patient with DDD using a split‐side technique.…”

Section: Treatmentmentioning

confidence: 99%

Dowling‐Degos disease: a review

2020

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Dowling‐Degos disease is a rare autosomal dominant genodermatosis. It is characterized by acquired reticulate hyperpigmentation over the flexures, comedone‐like follicular papules, and pitted perioral scars that usually develop during adulthood. Mutations in genes affecting melanosome transfer, and melanocyte and keratinocyte differentiation have been implicated in the pathogenesis of this disease. These genes include KRT5, POFUT1, POGLUT1 and, most recently, PSENEN. Dowling‐Degos disease can be found in isolation or with other associated findings, most notably hidradenitis suppurativa. This condition belongs to a spectrum of conditions that all result in reticulate hyperpigmentation that at times are hard to distinguish from each other. The most closely linked entity is Galli‐Galli, which is clinically indistinguishable from Dowling‐Degos disease and can only be distinguished by the presence of acantholysis on microscopy. Unfortunately, Dowling‐Degos disease is generally progressive and recalcitrant to treatment.

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“…[ 3 ] It is due to dysfunctional mutations in the keratin 5 gene (KRT5) located on chromosome 12q leading to haploinsufficiency in the keratin gene resulting in defective melanosome uptake and defect in hair follicle structure and sebaceous glands. [ 4 ]…”

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confidence: 99%