Successful management of testicular primitive neuroectodermal tumor with multiple bone metastases

Takasawa, Takuya; Minagawa, Tomonori; Domen, Takahisa; Fukushima, Toshirou; Fujii, Yu; Iwaya, Mai; Koizumi, Tomonobu; Ogawa, Toshihide; Ishizuka, Osamu

doi:10.1002/iju5.12431

Cited by 2 publications

(4 citation statements)

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“…ALPs have been studied extensively in various types of tumors and have shown potential as diagnostic, prognostic, and therapeutic markers. One of the key applications of ALPs in tumor diagnosis is as a marker for bone metastases ( 15 , 19 , 37 , 54 , 57 ). Elevated levels of ALPs in the blood have been shown to be associated with bone metastases in prostate cancer, breast cancer, and other types of cancer ( 34 , 36 ).…”

Section: Discussionmentioning

confidence: 99%

“…ALPs have been studied in testicular cancer, specifically in non-seminoma germ cell tumors (NSGCTs), and have shown potential as a diagnostic and prognostic marker ( 56 ). In NSGCT, elevations in serum ALP levels are commonly seen when there is a presence of metastases in the body, primarily bone metastases ( 57 ). Elevated ALP levels can aid in the diagnosis of NSGCT and in monitoring the treatment response of the tumor.…”

Section: Alps In Testicular Cancermentioning

confidence: 99%

“…Elevated ALP levels can aid in the diagnosis of NSGCT and in monitoring the treatment response of the tumor. Studies have suggested that high ALP levels in NSGCT patients are associated with an increased risk of disease recurrence and a decreased overall survival rate, indicating a potential role for ALP as a prognostic marker ( 57 - 59 ). ALP can also help identify chemotherapy-resistant or metastatic NSGCT, which can guide personalized treatment decisions ( 59 ).…”

Section: Alps In Testicular Cancermentioning

confidence: 99%

“…In these cases, monitoring of ALP levels can be an important tool in the management of cancer treatment. ALP levels have also been studied as potential prognostic biomarkers in chemotherapy-treated cancer patients ( 57 , 58 ). In some studies, a reduction in ALP levels after chemotherapy has been associated with improved outcomes in certain types of cancer, including CRC and pancreatic cancer ( 28 , 29 , 52 ).…”

Section: Alps In Chemotherapy and Radiation Therapymentioning

confidence: 99%

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Do alkaline phosphatases have great potential in the diagnosis, prognosis, and treatment of tumors?

Jiang,

Zeng,

2023

Transl Cancer Res

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Alkaline phosphatase (ALP) is a group of enzymes that catalyze hydrolysis of phosphate esters at an alkaline pH, resulting in the generation of inorganic phosphate. These enzymes are widely distributed, and their activity is found in various tissues including bone, liver, intestine, and placenta. However, abnormalities in ALP expression and activity have been observed in certain types of cancer. In some cases, elevated serum levels of ALP are observed in patients with liver and bone metastasis. In other cases, increased levels of ALP have been observed in patients with pancreatic and lung cancer. On the other hand, low expression of ALP has also been associated with poor prognosis in patients with certain types of tumors, including colorectal cancer (CRC), breast cancer, and non-small cell lung cancer (NSCLC). In these cases, low ALP activity may be associated with decreased differentiation of cancer cells and increased cancer cell proliferation. Overall, the role of ALP in cancer is complex and context-dependent. This article reviews application progress of ALP in cancer, and we hypothesize that ALP might be a potential tumor biomarker, combined detection of aspartate aminotransferase (AST)/alanine aminotransferase (ALT), bone-specific alkaline phosphatase (BSAP), carbohydrate antigen 19-9 (CA 19-9), lactate dehydrogenase (LDH) and ALP isozymes levels can be used for more accurate diagnosis of a particular tumor. Further research is needed to better understand the mechanisms underlying ALP dysregulation in cancer and to identify potential therapeutic targets.

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