Successful Meropenem Therapy of a Brain Abscess and Meningitis Arising From Acute Purulent Otomastoiditis: Case Report

Fulminant ependymitis following intraventricular rupture of brain abscess

“…We suspected that Staphylococcus spp. might be the causative pathogen, considering the history of penetrating brain injury [7]. No bacteria were isolated from CSF or blood cultures, however, and the same antibiotics were continued.…”

“…and meropenem (4 g b.i.d. ), was initiated to destroy both Gram-positive and Gram-negative bacteria [7]. We suspected that Staphylococcus spp.…”

Complicated acute mastoiditis with temporal subdural abscess and otogenic lateral sinus thrombosis: A case report

“…We know from Literature that mastoiditis complicates a middle otitis with a frequency of 1.2 to 3.8 cases per 100,000 children-year. It is usually supported by Pneumococcus and does not necessarily need to be treated surgically [1,2]. Our usual attitude is to hospitalize children with clinically suspicious otomastoiditis, where an Otorhinolaringologist find a post-auricular inflammation, with swelling, hyperemia or retroauricular pain [3].…”

Eikenella corrodens Brain Abscess after Repeated Periodontal Manipulations Cured with Imipenem and Neurosurgery

“…In the third case generalized seizures persisted after switching from imipenem to penicillin and the addition of phenytoin and clonazepam. Meropenem, another carbapenem with excellent in vitro activity against gram-negative rods, is less epileptogenic and potentially could be an excellent alternative to imipenem [17,18]. E. corrodens is also sensitive to ampicillin and thirdgeneration cephalosporins (cefotaxime, ceftriaxone and ceftazidime) [11,19].…”