Abstract:The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simult… Show more
“…This was not the case for those patients who showed lower reactivity. For some contact allergens (in the particular case, a photocontact allergen), for example ketoprofen , a much shorter occlusion time (1 hr) than 48 hrs seems to be as effective as the traditional occlusion period.…”
SummaryThe present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement. Finally, short reference is made to aspects of (continuing) medical education and to electronic collection of data for epidemiological surveillance.
“…This was not the case for those patients who showed lower reactivity. For some contact allergens (in the particular case, a photocontact allergen), for example ketoprofen , a much shorter occlusion time (1 hr) than 48 hrs seems to be as effective as the traditional occlusion period.…”
SummaryThe present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement. Finally, short reference is made to aspects of (continuing) medical education and to electronic collection of data for epidemiological surveillance.
“…The analogues of ketoprofen, piketoprofen and dexketoprofen have a similar behaviour concerning photosensitivity. 61,98 New topical formulations of ketoprofen in plaster aim to reduce UV exposure of the drug, but do not completely hinder this particular side-effect.…”
A fotossensibilidade induzida por fármacos traduz uma resposta cutânea anormal à luz em indivíduos expostos a um fármaco, os quais, na sua ausência, tolerariam o mesmo grau de fotoexposição. Pode ocorrer como uma reação aguda ou retardada, assumindo características clínicas polimórficas que variam desde a queimadura solar exagerada até aspectos de fotoonicólise, pseudo- -porfíria, pigmentação, eczema agudo e lúpus eritematoso cutâneo. Os autores descrevem os fármacos mais frequentemente envolvidos neste tipo de reações e as formas clínicas mais frequentes e discutem o possível contributo destes fármacos na potenciação da fotocarcinogénese. O reconhecimento d estes padrões clínicos de fotossensibilidade e dos fármacos responsáveis é fundamental para a evicção do fármaco causal e consequente melhoria ou resolução da reação de fotossensibilidade.
“…The ideal variables for each chemical, namely, the ideal exposure time, are not precisely known. Studies with ketoprofen have shown that 1 h of application is enough for skin penetration and induction of positive photopatch tests [10], but no studies have been done with other chemicals.…”
Photopatch testing is a procedure that combines patch testing with UV irradiation. It is primarily indicated to study photoallergic contact dermatitis, but it can also contribute to establish a correct diagnosis of any exposed site dermatitis or systemic drug photosensitivity. Photopatch testing has been standardized with the input of the European Society of Contact Dermatitis and European Society of Photodermatology, but it is still seldom performed. It consists on the application of two sets of allergens for 1 or 2 days, irradiation of one set at D1 or D2 with 5 J/cm 2 of UVA, and readings immediately after irradiation and two or more days thereafter. A European photopatch test
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