Successful Pregnancy after Microsurgical Transplantation of an Intact Ovary

Abstract

correspondence n engl j med 359;24 www.nejm.org december 11, 2008 2617 these two lines of evidence provide support for the role of the NHERF1 variants in the decrease in TmP/GFR values in our patients.Since FGF-23 decreases renal phosphate reabsorption and can induce hypophosphatemia, we studied patients with normal serum FGF-23 concentrations. Rendina et al. hypothesized that serum FGF-23 concentrations should be low in patients with hypophosphatemia. Undetectable FGF-23 levels are considered normal. We did not assess the serum FGF-23 concentrations in our patients according to whether the TmP/GFR values were normal or low, so we do not know whether hypophosphatemia lowered FGF-23 production. Although the serum FGF-23 concentration correlates with the serum phosphate con-The New England Journal of Medicine Downloaded from nejm.org at NYU WASHINGTON SQUARE CAMPUS on May 30, 2015. For personal use only. No other uses without permission.

The human postmenopausal ovary as a tool for evaluation of cryopreservation protocols towards whole ovary cryopreservation

“…We did not specifically measure the width of the arterial lumen in our patients but noted great variations. The diameter of the ovarian artery lumen in premenopausal women is stated to be 0.5-0.8 mm [9] and it is quite likely that the ovarian artery of a postmenopausal ovary is of smaller diameter, considering the decrease in ovarian blood flow after menopause. The backtable procedure, to trim the ends of the blood vessels and cannulation, would of course be aided by use of a dissection microscope, in line with our experience to cannulate the small common iliac arteries of the rat during flushing a uterine graft [18].…”

“…The microsurgical vascular anastomoses of the human ovarian arteries and veins is achievable as illustrated by successful heterotopic auto-transplantation [7,8] and orthotopic transplantation between monozygotic twins [9]. A live birth was reported by the latter method [9].…”

“…A live birth was reported by the latter method [9]. The main challenge concerning human whole ovary cryopreservation is to overcome the complex cryobiological properties of the large ovarian tissue.…”

Optimizing cryoprotectant perfusion conditions for intact ovary: a bovine model

“…Spontaneous pregnancies after transplantation of an intact ovary with microvascular anastomosis have occurred in rat, ewe, and human [12][13][14]. It shows that this technique is promising.…”

First pregnancy in Russia after orthotopic transplantation of cryopreserved ovarian tissue in a patient with Hodgkin’s disease: (case report)

“…Однако описан случай рождения здорового ре-бенка после трансплантации размороженной ткани яичника в гетеротопическое место [10]. На сегод-няшний день данный подход активно применяют перед гонадотоксичным противоопухолевым лече-нием и опубликованы сообщения о рождении около 40 здоровых детей по всему миру [11][12][13][14][15][16][17][18][19].…”