Successful Skin Homografts in Mature Non-littermate Rats Treated with Fractions Containing Alpha-globulins.

Kamrin, Benjamin B.

doi:10.3181/00379727-100-24522

Cited by 69 publications

(12 citation statements)

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“…The occurrence of a lymphocyte reactivity depressive factor (LDF) in serum was noted by Kamrin (1959) whilst Mowbray (1963a, b) and Mowbray and Hargrave (1966) found that a serum factor could diminish antibody response in experimental animals. Cooperband et al (1968) (Heilman and MacFarland, 1966); hepatitis (Paronetto and Popper, 1970); ataxia telangiectasia (MacFarlin and Oppenheim, 1969); secondary syphilis (Levene et al, 1969); chronic candidiasis (Canales et al, 1969); Hodgkin's disease (Trubowitz, Masek and del Rosario, 1966); as well as cancer (Trubowitz et al, 1966;Salk, 1967;and others).…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Sensitization in Advanced Malignant Disease: A Study of Serum Lymphocyte Depressive Factor

Field¹,

Caspary²

1972

Br J Cancer

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Summary.-Patients with advanced malignant disease show an apparent lesser degree of lymphocyte sensitization to cancer antigen when tested under standard conditions than do early cases. In the serum of cancer patients there is a lymphocyte response depressing factor whose titre rises as the neoplasm becomes more extensive. The low lymphocyte response shown by advanced cancers is not, however, directly referable to this rise in depressive factor, but to removal by the tumour mass of specifically sensitized lymphocytes so that amongst the standard number of cells under routine test an adequate number does not remain to give a full response. Increasing the number of cells under test restores the result to the level found in moderately sized cancers. The " absorptive capacity " of large tumours for circulating sensitized lymphocytes is greater than can be provided by natural immunization produced by the tumour. Active immunization with a tumour antigen can be expected therefore to increase lymphocyte -associated defence against cancer.

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Section: Discussionmentioning

confidence: 99%

Lymphocyte Sensitization in Advanced Malignant Disease: A Study of Serum Lymphocyte Depressive Factor

Field¹,

Caspary²

1972

Br J Cancer

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“…During the past dec ade, several investigators have described the endogenous immunosuppres sants, derived from human and mammalian tissues such as plasma [8,15,16], thymus [2,3], spleen [4], placenta [10,17] and amniotic fluid [12] etc., and the exogenous ones mainly originated irom bacteria. In regard to the streptococcal organism, H a n n a and W a tso n [5] described the immu nosuppressive effect of pyrogenic exotoxin from group A streptococci.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of <sup>3</sup>H-Thymidine Incorporation into Human Lymphocytes by Dialyzable Material of Streptokinase-Streptodornase

Kuroume¹,

Suzuki²,

Nemoto³

et al. 1976

Int Arch Allergy Immunol

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Using the ³H-thymidine incorporation test, the lymphocyte-stimulating activity of streptokinase-streptodornase (SK-SD, Varidase) and its fractions were evaluated. The dose-response curves of all the preparations except the third fraction had two peaks with the maximum around 5 and 40 μg. The dialyzable fraction of Sk-SD (D-SK-SD) occupying approximately half of the original sample had almost no lymphocyte-stimulating activity; and conversely, it had a potent inhibitory effect on the ³H-thymidine incorporation into lymphocytes that normally occurs with non-dialyzable SK-SD (ND-SK-SD), PPD and PHA-P. Therefore, it will be desirable to remove the dialyzable fraction from the commercial SK-SD preparation when it is used for the determination of the capacity of cellular immunity against SK-SD.

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“…Similarly, effector cells active in reactions of delayed hypersensitivity are subjected to augmenting and suppressing influences imposed by other T cells, B cells, and macrophages (6,(20)(21)(22)(23). Additionally, both T-and B-cell reactivity can be affected by an increasing list of soluble substances which may be produced exogenously by other nonlymphoid cells (24)(25)(26)(27)(28). This variety of mechanisms by which immunologic reactivity may be impaired is reflected by the heterogeneity of immunologic defects detected in patients with fungal infection; some of which are depicted by the three groups of patients indicated here and many of which have been reported previously (2,3,(29)(30)(31)(32)(33)(34).…”

Section: Methodsmentioning

confidence: 99%

Suppressor thymus-derived lymphocytes in fungal infection.

Stobo¹,

Paul²,

Scoy³

et al. 1976

J. Clin. Invest.

235

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Successful Skin Homografts in Mature Non-littermate Rats Treated with Fractions Containing Alpha-globulins.

Cited by 69 publications

References 0 publications

Lymphocyte Sensitization in Advanced Malignant Disease: A Study of Serum Lymphocyte Depressive Factor

Lymphocyte Sensitization in Advanced Malignant Disease: A Study of Serum Lymphocyte Depressive Factor

Inhibition of <sup>3</sup>H-Thymidine Incorporation into Human Lymphocytes by Dialyzable Material of Streptokinase-Streptodornase

Suppressor thymus-derived lymphocytes in fungal infection.

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