Successful soft and hard tissue augmentation with platelet‐rich fibrin in combination with bovine bone space maintainer in a delayed implant placement protocol in the esthetic zone: A case report

Brouwers, Joost E. I. G.; Buis, Sharon; Haumann, Rianne; Groot, Philip Ph. G. de; Laat, Bas de; Remijn, Jasper A.

doi:10.1002/ccr3.2177

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Thus, surface topography and chemistry can be manipulated to promote the adhesion of membranes with drug/peptide therapeutics for eliciting antimicrobial action in response to multiple oral diseases. Examples of other potential applications in dentistry taking advantage of the dual hard−soft tissue adhesion properties of these membranes are guided bone regeneration (GBR), 45 synthetic gingival grafts to treat gingival recession in chronic periodontitis, 46 augmentation of periimplant tissues, 47 and temporary toothache relief or tooth numbing. 48 The versatility of our membranes is reliant on the easy incorporation in the fibrillary structure of multiple biologicals, drugs, and/or anesthetics depending on the specific application.…”

Section: Discussionmentioning

confidence: 99%

Dual Oral Tissue Adhesive Nanofiber Membranes for pH-Responsive Delivery of Antimicrobial Peptides

Boda

Fischer

et al. 2020

Biomacromolecules

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Bioadhesive membranes with controllable and reversible underwater adhesion are desirable for several biomedical applications ranging from biosensing, drug/therapeutic delivery, and tissue regeneration. Here, we present dual soft mucosal and hard bone/enamel tissue adhesive nanofiber membranes composed of chitosan and pectin derivatives for pH-controlled delivery of antimicrobial peptides (AMPs) in the oral cavity. Ex vivo testing with porcine esophagus (soft mucosal mimic) indicated a 2-fold increase in the mucoadhesion of chitosan membranes with 0.05 wt % oxidized pectin coating, while the uncoated membranes exhibited 3–4-fold stronger adhesion to hydroxyapatite discs (enamel/hard bone mimic) compared to the coated membranes. The former is attributed to a synergistic interaction of surface nanofiber topography, intermolecular hydrogen bonding, and aldehyde–amine chemistry between surface polar groups and mucosal proteins, while the latter may arise from electrostatic interactions between cationic amines (−NH3 +) in chitosan and anionic phosphates (−PO4 3–) in hydroxyapatite. Further, the dual hard–soft oral tissue adhesive nanofiber membranes loaded with cationic amphipathic AMPs (D-GL13K and IDR-1018) elicited pH-responsive AMP delivery and antimicrobial action comparable to chlorhexidine (CHX) against oral streptococci. Concurrently, the AMP loaded membranes were cytocompatible to both soft epithelial tissue-derived human oral keratinocytes and hard calvarial murine pre-osteoblast cells. We envision these membranes to function as adhesive gingival grafts and guided bone regeneration (GBR) membranes at the hard–soft tissue interface while simultaneously protecting against oral infections.

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Section: Discussionmentioning

confidence: 99%

Dual Oral Tissue Adhesive Nanofiber Membranes for pH-Responsive Delivery of Antimicrobial Peptides

Boda

Fischer

et al. 2020

Biomacromolecules

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“…The three-dimensional mesh architecture of PRF could release the growth factors slowly and accelerate the healing of both soft and hard tissues[ 8 , 9 ]. The application of PRF could not only benefit the construction of osteogenic environment but also repair the regeneration of soft tissue in the treatment of immediate implant placement[ 10 , 11 ]. In addition, various kinds of leukocytes in PRF (especially granulocytes and lymphocytes) also present a noticeable impact on antimicrobial and immuno-modulatory effects, which could reduce the inflammatory response of wound healing and prevent the infected risk of chronic periodontitis[ 12 - 15 ].…”

Section: Introductionmentioning

confidence: 99%

Immediate implant placement in combination with platelet rich-fibrin into extraction sites with periapical infection in the esthetic zone: A case report and review of literature

Fang

Xin

et al. 2021

WJCC

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BACKGROUND In this case, platelet-rich fibrin (PRF) was added to guided tissue regeneration as a biomaterial in proper order for immediate planting in aesthetic area with periapical infection. CASE SUMMARY With the history of endodontic failure in maxillary central incisor, a 34-year-old female patient required the extraction of maxillary anterior residual root and immediate implantation. Cone beam computed tomography and clinical observation were used to assess the regeneration of soft and bone tissue. Before operation, cone beam computed tomography showed the anterior residual root had serious periapical periodontitis with insufficient labial bone in the aesthetic zone. The patient underwent immediate implant placement and reconstruction of the bone substitution by modified guided bone regeneration. The barrier was a three-layer structure of PRF-collagen membrane-PRF that covered the mixture of PRF and Bio-Oss to promote both osteogenesis and soft tissue healing. At 6 mo postoperatively, the definitive crown was placed after accomplished finial impression. One-year follow-up showed a satisfactory aesthetic effect with no obvious absorption of the labial bone and soft tissue. CONCLUSION The use of PRF in combination with guided bone regeneration can serve as a reliable and simple adjuvant for immediate implanting in infected socket and result in a stable osteogenic effect with good aesthetic outcome.

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“…8 However, studies on PRF's ability to increase peri-implant mucosal thickness are limited. 9,10 Then, this study aimed to assess whether the use of PRF membranes would increase the peri-implant mucosal thickness when a delayed implant placement protocol was followed, in the anterior maxilla area, after 3 months of follow-up.…”

Section: Introductionmentioning

confidence: 99%

“…Platelet‐rich fibrin (PRF) stimulates cell migration and proliferation and can speed up soft tissue healing due to its ability to release growth factors and cytokines 8 . However, studies on PRF's ability to increase peri‐implant mucosal thickness are limited 9,10 . Then, this study aimed to assess whether the use of PRF membranes would increase the peri‐implant mucosal thickness when a delayed implant placement protocol was followed, in the anterior maxilla area, after 3 months of follow‐up.…”

Section: Introductionmentioning

confidence: 99%

Use of Platelet‐Rich Fibrin Membranes With Single Implant Placement for Peri‐Implant Mucosal Thickness Augmentation: A Case Series Study

Lima

Miguel

Ferraz

et al. 2021

Clin Adv Periodontics

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Introduction:The use of platelet-rich fibrin (PRF) membranes has been evaluated for different purposes. However, few studies aimed to assess the effect of PRF membranes on peri-implant mucosal thickness augmentation. Thus, the aim was to evaluate whether the use of PRF membranes placed using the same surgical procedure of single implant installation in the anterior area of the maxilla can result in peri-implant mucosal thickness increase. Case series:Eight patients received single maxillary implants (anterior area), covered by three PRF membranes (2,500 rpm/12 minutes, RCFmax = 719.71 g). Clinical parameters (baseline and 3 months postoperative) and patientcentered parameters were evaluated. The buccal peri-implant mucosal thickness (BMT) and ridge defect (RD) parameters showed a statistically significant difference, with a gain of 0.7 ± 0.3 mm in BMT and reduction of 0.8 ± 0.3 mm in RD. Supracrestal tissue height (STH) was >3 mm after 3 months. Postoperative pain and number of analgesics showed low values (0.95 ± 1.06 and 1.92 ± 2.75), respectively, using a visual analog scale (VAS). Conclusion:The use of three PRF membranes along with single implant placement in the anterior maxilla led to an increase in the BMT.

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Successful soft and hard tissue augmentation with platelet‐rich fibrin in combination with bovine bone space maintainer in a delayed implant placement protocol in the esthetic zone: A case report

Cited by 5 publications

References 23 publications

Dual Oral Tissue Adhesive Nanofiber Membranes for pH-Responsive Delivery of Antimicrobial Peptides

Dual Oral Tissue Adhesive Nanofiber Membranes for pH-Responsive Delivery of Antimicrobial Peptides

Immediate implant placement in combination with platelet rich-fibrin into extraction sites with periapical infection in the esthetic zone: A case report and review of literature

Use of Platelet‐Rich Fibrin Membranes With Single Implant Placement for Peri‐Implant Mucosal Thickness Augmentation: A Case Series Study

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