Brainstem pilocytic astrocytomas are benign lesions that frequently develop in the medulla with an often exophytic component. [1][2][3] These lesions develop in children and young adults and are revealed by lower cranial nerves dysfunction and long tracts involvement. Medulla pilocytic astrocytomas have a better overall prognosis than pontine and midbrain lesions, particularly after surgical resection, which can be curative, allowing the control of the disease and avoiding adjuvant treatments in young patients. [2][3][4][5] The transcondylar approach with mobilization of the vertebral artery offers the necessary ventral exposure for the resection of such medulla oblongata lesions. 6 After exposure, the initial step of resection starts with the cerebellopontine angle occupying exophytic portion after identification of cerebrovascular landmarks. Ultrasonic aspiration on a low setting allows to progressively debulk the tumor and identify the normal medulla tissue while closely following the electrophysiological neuromonitoring. Preservation of the small medulla perforators is the key for successful resection, including minimal use of bipolar coagulation in the vicinity of brainstem tissue. We demonstrate these principles through the case of a 33-year-old woman presenting with a large left medulla oblongata exophytic tumor, with an MRI presentation consistent with pilocytic astrocytoma. The patient consented to the procedure and publication of her images.