2004
DOI: 10.1097/01.inf.0000136870.17071.fd
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Successful Treatment of a Child with Posttraumatic Necrotizing Fasciitis Caused by Apophysomyces elegans: Case Report and Review of Literature

Abstract: Apophysomyces elegans is an uncommon human pathogen that causes deeply invasive infections in immunocompromised patients and cutaneous infection in immunocompetent patients. We report the development of severe deep soft tissue zygomycosis caused by A. elegans in an otherwise healthy child after trauma. She was successfully treated with surgical debridements and antifungal therapy with liposomal amphotericin B. A review of the literature indicates that zygomycosis caused by A. elegans is associated with traumat… Show more

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Cited by 56 publications
(24 citation statements)
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“…Fever has been described in several cases (70,170,187,223,358,363). In some cases, cotton-like, fine white fluffy material with a woolly appearance or a white cottony filamentous structure covering a wound base has also been observed (47,58,170,223,291,298,355).…”
Section: Apophysomyces Elegans Complexmentioning
confidence: 99%
See 1 more Smart Citation
“…Fever has been described in several cases (70,170,187,223,358,363). In some cases, cotton-like, fine white fluffy material with a woolly appearance or a white cottony filamentous structure covering a wound base has also been observed (47,58,170,223,291,298,355).…”
Section: Apophysomyces Elegans Complexmentioning
confidence: 99%
“…Fever has been described in several cases (70,170,187,223,358,363). In some cases, cotton-like, fine white fluffy material with a woolly appearance or a white cottony filamentous structure covering a wound base has also been observed (47,58,170,223,291,298,355). Although Apophysomyces elegans infections may occur in any region of the body, the extremities, abdominal wall, and perineum are the most common sites (47,70,144,221,223,291,298,363 (ii) Rhino-orbito-cerebral infection.…”
Section: Apophysomyces Elegans Complexmentioning
confidence: 99%
“…Secondary vascular invasion may also lead to hematogenously disseminated infection of the deep organs. Cutaneous and subcutaneous disease may lead to necrotizing fasciitis, which has a mortality approaching 80% (18,80,115,124). However, isolated cutaneous mucormycosis (i.e., not disseminated disease) has a favorable prognosis and a low mortality if aggressive surgical debridement is done promptly (4).…”
Section: Epidemiology and Disease Manifestationsmentioning
confidence: 99%
“…While most of the reports in the literature involve disruption of an extensive amount of the cutaneous surface [22, 24, 49], occasionally invasive disease is reported after only a minor insult [50]. Among the US military case series, wound cultures grew only Mucorales in 35 % [5, 35].…”
Section: Clinical Mycologymentioning
confidence: 99%