Successful treatment of disseminated superficial actinic porokeratosis with calcipotriol

Bakardzhiev, Ilko; Kavaklieva, Svetlana; Pehlivanov, Georgy

doi:10.1111/j.1365-4632.2010.04704.x

Cited by 16 publications

(5 citation statements)

References 16 publications

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“…Traditional topical treatment approaches include topical treatments like diclofenac [10][11][12], imiquimod [13][14] and calcipotriol [15][16][17][18][19]. Oral retinoids [20][21][22] and cryotherapy [15] were used in the past with no any satisfied results.…”

Section: Discussionmentioning

confidence: 99%

Two cases of disseminated superficial actinic porokeratosis (DSAP) and treatment literature review

Thomaidou¹,

Katz²,

Leibovici³

2018

Our Dermatol Online

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Background: Disseminated superficial actinic porokeratosis (DSAP) is characterized by asymptomatic multiple papules with annular keratotic rim distributed symmetrically on the sun-exposed areas. Many approaches have been proposed in the past for treating DSAP, but the therapy is still a challenge for every physician, mostly because of the frequent relapses of the disease and the multiplicity of the skin lesions. Material and Methods: Two case reports were reported emphasizing the challenges of treatment approach. Therefore, a systemic English literature review was conducted searching Medline database using PubMed Central and Ovid software as search interface to collect evidence based on the various treatment modalities for DSAP. Results: The initial search yielded 146 articles, but only the relevant case reports, case series and studies relating to the treatment of DSAP have been described and summarized in a table. For each different therapy the efficacy of each treatment, side effects, cost-effectiveness and authors' recommendations were reported. Conclusion: Several factors need to be considered prior to physicians' decision of the most appropriate treatment for each patient like age, the extent of body surface area involvement, patients' medical history and social situation, the available resources, the side effects and cost-effectiveness of each treatment. However, l the exact value of each treatment is difficult to determine owing to the lack of controlled studies evaluating their efficacy. Due to few incidences of squamous cell carcinoma, patients need to be followed up and monitored closely for any early detection of recurrence or possible onset of malignancies.

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Section: Discussionmentioning

confidence: 99%

Two cases of disseminated superficial actinic porokeratosis (DSAP) and treatment literature review

Thomaidou¹,

Katz²,

Leibovici³

2018

Our Dermatol Online

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“…79,83,84 Significant improvement to complete remission was observed in 86% of patients (6 of 7), with duration of treatment ranging from 6 weeks to 19 months. [79][80][81][82][83] Chronic disease characterized by facial hyperpigmentation appeared to be more resistant and to require a longer duration of treatment-up to 19 months in one patient. 79 One particular split-face trial showed that CO 2 laser was superior to topical talcalcitol, which produced no improvement in a patient with a 20-year history of hyperpigmented papules to the face.…”

Section: Disseminated Superficial Actinic Porokeratosismentioning

confidence: 95%

“…Six case reports (n 5 7) described the use of calcipotriol, tacalcitol, or maxacalcitol in the treatment of disseminated superficial actinic porokeratosis (DSAP). [79][80][81][82][83][84] Three of seven patients were of Asian descent with type III-IV skin. 79,83,84 Significant improvement to complete remission was observed in 86% of patients (6 of 7), with duration of treatment ranging from 6 weeks to 19 months.…”

Section: Disseminated Superficial Actinic Porokeratosismentioning

confidence: 99%

Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Wat

Dytoc

2014

J Cutan Med Surg

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“…The results seem to be promising, yet have not been confirmed in randomised trials. Monotherapy or combination treatment including topical vitamin D3 analogs have been reported to be effective: calcipotriol 0.005% twice daily [133,134], tacalcitol 0.002% or 0.004% [135,136], calcipotriol 0.005%/adapalene 0.1% gel [137], calcipotriol/betamethasone gel [138] and CO 2 laser with tacalcitol 0.002% ointment [139]. A combination of calcipotriol and 5-fluorouracil (5-FU) provided a moderate effect (some flattening of the lesions) [71].…”

Section: Treatmentmentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Successful treatment of disseminated superficial actinic porokeratosis with calcipotriol

Cited by 16 publications

References 16 publications

Two cases of disseminated superficial actinic porokeratosis (DSAP) and treatment literature review

Two cases of disseminated superficial actinic porokeratosis (DSAP) and treatment literature review

Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

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