Successful Treatment of Eccrine Angiomatous Hamartoma With Botulinum Toxin

Barco, D.; Baselga, Eulàlia; Alegre, M.; Curell, Romà; Alomar, A.

doi:10.1001/archdermatol.2008.575

Cited by 39 publications

(33 citation statements)

References 21 publications

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“…Aside from cosmetic reasons, these lesions do not require treatment [3,16,20]. Treatment with botulinum toxin and intralesional sclerosants has been successfully used in cases of EAH [27,28]. Hyperhidrosis and excessive neuromuscular activities are the main indication for botulinum toxin treatment in EAH [27].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment with botulinum toxin and intralesional sclerosants has been successfully used in cases of EAH [27,28]. Hyperhidrosis and excessive neuromuscular activities are the main indication for botulinum toxin treatment in EAH [27]. Barco et al [27] described botulinum toxin to be able to activate a temporary chemodenervation at the presynaptic nerve terminals, blocking the acetylcholine release, reducing the activity of the target striated muscular and autonomic structures as well as decreasing muscle tone and eccrine sweat gland secretion.…”

Section: Discussionmentioning

confidence: 99%

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Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Sanusi

Li²,

Sun³

et al. 2015

Dermatology

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Background: Eccrine angiomatous hamartoma (EAH) is a rare benign cutaneous tumor characterized by the proliferation of eccrine glands and capillaries. Objective: The aim of this study was to summarize the clinicopathological characteristics of EAH. Methods: A retrospective chart review was performed on all patients diagnosed with EAH from 1977 to 2012 in the Union Hospital, Wuhan, P.R. China, and the clinicopathological features were compared with the cases reported in the literature. Results: A total of 26 patients with EAH were identified. The male:female ratio was 1.2:1. EAH most commonly presents as a solitary (80.8%) plaque (50.0%) on the lower extremities (61.5%). Most patients presented with hyperhidrosis localizing to the lesion. Although most patients did not have major pain or anatomic deformity, one patient had severe pain as well as difficulty walking and moving, necessitating leg amputation. The histopathological findings showed typical features of EAH. Conclusion: EAH is a rare but characteristically benign skin hamartomatous condition. In rare occasions it can be associated with severe structural and functional impairment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Sanusi

Li²,

Sun³

et al. 2015

Dermatology

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“…2,3,[5][6][7] Non-invasive treatments comprise of topical antiperspirants or intralesional injections of botulinum toxin type A. 8 As surgery was rejected due to size and topical ointments due to location, botulinum toxin type A was preferred. In this case rapid relieve of hyperhidrosis was achieved resulting in an increase in patient quality of.…”

Section: Discussionmentioning

confidence: 99%

“…4 It is important to recognize the hamartoma as a benign clinical entity, for which aggressive management is not necessary, yet treatment including surgery or topical therapies is occasionally needed to alleviate pain or hyperhidrosis. 2,3,[5][6][7][8][9] While clinical examination can give meaningful clues, the diagnosis is based on the histologic criteria for EAH, which is defined as (1) proliferation of mature, normal or dilated eccrine glands, (2) intimate association of the eccrine structures with benign vascular proliferation, and (3) varying occurrence of pilar, lipomatous, mucinous, and/or lymphatic structures. 1,2,4,10 We present a case of EAH disclosing distinct histopathological features of the previously reported, though rare, mucinous EAH variant but of extraordinary size several hundred times larger than commonly seen.…”

Section: Introductionmentioning

confidence: 99%

Large eccrine angiomatous hamartoma: a novel clinical presentation of disease

Nygaard

Dalager

Spaun

et al. 2015

J Dermatol Case Rep

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Background: Eccrine angiomatous hamartoma is a rare benign cutaneous malformation with a diverse clinical appearance, therefore likely to be misdiagnosed and underreported.Main observations: A 44-year-old man presented with a congenital erythematous hyperhidrotic plaque on the left upper back measuring 18 x 25 cm. No pain or tenderness nor hypertrichosis were observed. Histopathology was consistent with the mucinous variant of eccrine angiomatous hamartoma. Intralesional injection of botulinum toxin type A greatly reduced localized sweating, improving patient quality of life. Conclusions:This article describes a novel clinical presentation of eccrine angiomatous hamartoma: large, erythematous, and slightly indurated plaque localized on the upper back. It emphasizes the role of histopathology in the diagnostic process and botulinum toxin as a viable treatment option. (J Dermatol Case Rep. 2015; 9(3): 58-61)

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“…12,13 Botulinum toxin has been successfully used to treat the hyperhidrosis of EAH. 14 To the best of our knowledge, fewer than 10 cases of EAH with mucin deposition have been reported. The main difference between the present case and previously reported cases is that there was mucin deposition not only in the stroma surrounding the eccrine glands and vascular structures but also in the superficial dermis in the present case.…”

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confidence: 99%

Eccrine angiomatous hamartoma with sudden enlargement and pain in an adolescent girl after menarche

Kikusawa¹,

Oka²,

Taguchi

et al. 2011

Dermato-Endocrinology

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Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous lesion characterized histologically by a proliferation of eccrine glands and vascular structures-generally capillaries-in the middle and deep dermis. Sudden enlargement of EAH lesions with or without pain has been noted during puberty and pregnancy and has been attributed to hormonal stimulation. We herein describe a case of EAH that became symptomatic in an adolescent girl. A 13-year-old girl presented with pain associated with a sudden enlargement of a previously asymptomatic swelling on her right second toe. She had an 8-year history of an asymptomatic swelling on her right second toe, and the symptoms appeared approximately 1 year after menarche. Physical examination revealed swelling of the plantar surface of her right second toe. The overlying surface was erythematous with a small amount of fine scales. The biopsied tissue showed a nodular proliferation of eccrine glands intimately admixed with numerous small vessels in the deep dermis and subcutaneous fat tissue. Mucin deposition was present in the stroma surrounding the proliferating eccrine coils and ducts and in the upper dermis. A diagnosis of EAH was made. We suggest that hormonal changes during puberty may have played a role in the rapid growth and pain in the present case.Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous lesion characterized histologically by a proliferation of eccrine glands and vascular structures

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Successful Treatment of Eccrine Angiomatous Hamartoma With Botulinum Toxin

Cited by 39 publications

References 21 publications

Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Large eccrine angiomatous hamartoma: a novel clinical presentation of disease

Eccrine angiomatous hamartoma with sudden enlargement and pain in an adolescent girl after menarche

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