Successful treatment of frontal fibrosing alopecia with alitretinoin

Lee, Ji Young; Hong, John; Lee, Seung Ho; Lee, Ai-Young

doi:10.1111/dth.13037

Cited by 11 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A retrospective analysis of 54 women with FFA treated with oral isotreinoin (20 mg/day), acitretin (20 mg/day), or finasteride (5 mg/day) showed a stoppage of progression in 76%, 73%, and 43% of patients, respectively [ 197 ]. Alitretinoin has also been used in a woman with FFA, who showed improvement after one month with 30 mg/day [ 198 ].…”

Section: Treatmentmentioning

confidence: 99%

Frontal Fibrosing Alopecia: A Review

Porriño‐Bustamante

Fernández‐Pugnaire

Arias‐Santiago

2021

JCM

View full text Add to dashboard Cite

Frontal fibrosing alopecia is a scarring alopecia, the prevalence of which is increasing worldwide since its first description in 1994. The reason for this emerging epidemic may be a higher exposure to an unknown trigger, although its aethiology and pathogenesis still remain enigmatic. Clinical, trichoscopic, sonographic, and histopathologic findings are allowing clinicians to understand more aspects about this type of cicatricial alopecia. Several treatments have been used in frontal fibrosing alopecia, although the 5-alpha reductase inhibitors seem to be the most promising. The aim of this report is to provide a compilation about the published data regarding frontal fibrosing alopecia in a narrative review.

show abstract

Section: Treatmentmentioning

confidence: 99%

Frontal Fibrosing Alopecia: A Review

Porriño‐Bustamante

Fernández‐Pugnaire

Arias‐Santiago

2021

JCM

View full text Add to dashboard Cite

show abstract

“…Retinoic acid has been reported to be effective as a topical treatment in OLP [52,53]. Oral treatment of tretinoin (a generic name of Vitinoin) has been reported to be effective in treating LP [36]. In Supplementary Table 2_C, we provide enrichment analysis results pertaining to drug terms within DSigDB In Figure 7, two subgraphs obtained from PPI networks are shown, including the following 25 genes:…”

Section: Methods Rank Term Overlap P-valuementioning

confidence: 99%

“…Table 4 shows retrieved terms pertaining to drugs associated with provided genes. The first term is for the drug Alitretinoin, which has been shown to be clinically effective in the treatment of LP cases [36,37]. The 2nd-ranked drug was Vitinoin, the generic name of which is tretinoin, which has been included in clinical trials and has demonstrated potential improvements in the clinical treatments pertaining to LP [38,39].…”

Section: Tablementioning

confidence: 99%

GENEvaRX: A Novel AI-Driven Method and Web Tool Can Identify Critical Genes and Effective Drugs for Lichen Planus

Turki

Taguchi

2023

Preprint

View full text Add to dashboard Cite

Lichen planus (LP) is an autoimmune disorder diagnosed based on physical symptoms and lab tests. Examples of symptoms include flat bumps, and itchy and purplish skin, while lab tests include a shave biopsy of the lesion. When the pathology report shows consistency with LP and is negative for potential triggers for an allergy test and hepatitis C, a dermatologist typically prescribes corticosteroid in the form of pills or injection into the lesion to treat the symptoms. To understand the molecular mechanism of the disease and thereby overcome issues associated with disease treatment, there is a need to identify potential effective drugs, drug targets, and therapeutic targets associated the LP. Hence, we propose a novel computational framework based on new constrained optimization to support vector machines coupled with enrichment analysis. First, we downloaded three gene expression datasets (GSE63741, GSE193351, GSE52130) pertaining to healthy and LP patients from the gene expression omnibus (GEO) database. We then processed each dataset and entered it into our computational framework to select important genes. Finally, we performed enrichment analysis of selected genes, reporting the following results. Our methods outperformed baseline methods in terms of identifying disease and skin tissue. Moreover, we report 5 drugs (including, dexamethasone, retinoic acid, and quercetin), 45 unique genes (including PSMB8, KRT31, KRT16, KRT19, KRT17, COL3A1, LCE2D, LCE2A), and 23 unique TFs (including NFKB1, STAT1, STAT3) reportedly related to LP pathogenesis, treatments, and therapeutic targets. Our methods are publicly available in the GENEvaRX web server at https://aibio.shinyapps.io/GENEvaRX/.

show abstract

“…Frontal fibrosing alopecia (FFA) is an irreversible scarring cicatricial alopecia, manifesting as atrophic and band‐like recession of symmetric fronto‐temporal and fronto‐parietal hairline. FFA has been reported mainly in premenopausal women and rarely in men 1‐5 . It is considered a variant of lichen planopilaris (LPP) and is frequently associated with the presence of perifollicular erythema and scaling in the affected area.…”

Section: Introductionmentioning

confidence: 99%

“…FFA has been reported mainly in premenopausal women and rarely in men. [1][2][3][4][5] It is considered a variant of lichen planopilaris (LPP) and is frequently associated with the presence of perifollicular erythema and scaling in the affected area. The pathogenesis of FFA is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Allergic contact dermatitis in patients with frontal fibrosing alopecia: An international multi‐center study

Rudnicka

Rokni

Lotti

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Frontal fibrosing alopecia (FFA) mainly affects the anterior hairline and eyebrows and its etiology and associated factors remain obscure. The aim of this study was to evaluate the allergic contact dermatitis with patch test in patients with FFA. In this prospective study, 20 patients with FFA and 24 age and sex‐matched healthy individuals were evaluated with patch testing. Diagnosis was made histologically, clinically and based on dermoscopic findings. Demographic data, age of onset, disease duration and FFA severity index are evaluated in all patients. Positive patch test reaction to one or more allergen was observed in 65% of patients while it was 37.5% in control group (P = .003). There was a significant difference between age (P = .006) and positive patch test results. No statistical significant difference was observed in the results of patch testing and disease duration (P = .519), menopausal status (P = .085), and FFA severity index (P = .573). Our findings suggest an association between FFA and allergic contact dermatitis. The utility of patch testing in FFA patients can explore the role of allergic etiology and may have an enormous impact on the diagnostic potential and quality of life of these patients.

show abstract

Successful treatment of frontal fibrosing alopecia with alitretinoin

Cited by 11 publications

References 14 publications

Frontal Fibrosing Alopecia: A Review

Frontal Fibrosing Alopecia: A Review

GENEvaRX: A Novel AI-Driven Method and Web Tool Can Identify Critical Genes and Effective Drugs for Lichen Planus

Allergic contact dermatitis in patients with frontal fibrosing alopecia: An international multi‐center study

Contact Info

Product

Resources

About