Successful Treatment of Malignant Priapism by Radiotherapy: Report of a Case, Review of the Literature, and Treatment Recommendations

The Current Challenges in Diagnosing and Treating Malignant Priapism: A Comprehensive Review

“…In renal cell carcinoma (RCC), radiotherapy can be a treatment modality that significantly improves MP outcomes. 29 However, the guideline for optimal dose and fractionation in radiotherapy has not been published yet. High-dose palliative radiotherapy (40-50 Gy) is recommended due to the beneficial outcome for MP secondary to prostate, urothelial, and rectal carcinoma.…”

“…High-dose palliative radiotherapy (40-50 Gy) is recommended due to the beneficial outcome for MP secondary to prostate, urothelial, and rectal carcinoma. 13 , 26 - 29 The volumetric modulated arc therapy (VMAT), which is moderately hypo-fractionated high-dose radiotherapy, is preferred because of the simple patient setup and reducing patient stress. Specific in genitourinary or lower intestinal malignancies, which require high-dose radiotherapy and palliative pelvic radiotherapy, VMAT can minimize pelvic tissue damage.…”

“…Specific in genitourinary or lower intestinal malignancies, which require high-dose radiotherapy and palliative pelvic radiotherapy, VMAT can minimize pelvic tissue damage. 29 However, for the type of cancer resistant to radiotherapy and chemotherapy, persistent pain, and urine symptoms, surgical management, such as partial or complete penectomy, may be an effective therapy. Although total penectomy might cause psychological trauma and has limited survival benefits, it is pain free for the patient and improves the patient’s quality of life.…”

“… 2 , 33 In contrast, a cohort study conducted by Cocci et al 34 showed a better cancer survival time (CaST) when MP was presented as the first symptom of metastases; the median CaST of MP from urogenital origin was 30 months, which is longer than other origins with a median of 15 months. 29 , 34 Therefore, MP tends to have a poor prognosis, but it depends on the primary cancer.…”

Clinical analysis of secondary penile cancer: a case series at a tertiary referral center in China

“…For some patients, malignant priapism is a crucial manifestation of secondary penile cancer. 1 2 3 4 5 …”