Successful treatment of malignant rhabdoid tumor of the vulva in an older patient: a case report and review of the literature

Tzilinis, Argyrios; Clarke, Leon E.; Affuso, Cristina; Fessenden, John

doi:10.1016/s0149-7944(02)00652-9

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…Most of these tumors of the vulva are noted in the age group 30-50 years (7 of 10 cases reported earlier, Table 1), youngest patient being 19 years and oldest being 63 years of age. [3,5] Most of the reported MRTs of the vulva presented as a painless, firm-to-hard circumscribed mass of 2-to10 cmsize. Lymphatic spread was rare as in most of the other sarcomas compared to more common vulvar carcinomas.…”

Section: Discussionmentioning

confidence: 99%

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Malignant extrarenal rhabdoid tumor of the vulva in an adult

et al. 2010

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Sarcomas of the vulva account for only 1-3% of all vulvar malignancies. Most common vulvar sarcomas are leiomyosarcomas, malignant fibrohistiocytomas, and aggressive angiomyxomas. Malignant rhabdoid tumor (MRT) of the kidney is a distinctive clinicopathological entity that is recognized as a highly aggressive renal tumor of childhood. Extrarenal malignant rhabdoid tumors have been proposed to exist at several sites, including soft parts. MRT of the vulva is a rare and very aggressive neoplasm. Median survival reported in other studies is 9 months. Only 10 cases have been reported thus far in the English literature. We are reporting the 11 th case who remains disease free 30 months following surgery and radiotherapy till the time of reporting.

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Section: Discussionmentioning

confidence: 99%

“…Chemotherapy and radiotherapy do not appear to be effective in controlling recurrent or metastaic disease. [5,12,13] Table 1 shows a summary of reported cases of MRT of the vulva. …”

Section: Discussionmentioning

confidence: 99%

Malignant extrarenal rhabdoid tumor of the vulva in an adult

et al. 2010

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“…Based on this, we suspect that the cases of vulvar epithelioid sarcoma that have been reported in the literature account for only a fraction of the total. Additional examples of vulvar proximal‐type epithelioid sarcoma have likely been reported as malignant rhabdoid tumors in adults 97,121‐129 …”

Section: Epithelioid Sarcomamentioning

confidence: 99%

Update on SWI/SNF‐related gynecologic mesenchymal neoplasms: SMARCA4‐deficient uterine sarcoma and SMARCB1‐deficient vulvar neoplasms

Howitt

Folpe

2020

Genes Chromosomes & Cancer

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Our knowledge regarding the role of genes encoding the chromatin remodeling switch/sucrose non‐fermenting (SWI/SNF) complex in the initiation and progression of gynecologic malignancies continues to evolve. This review focuses on gynecologic tumors in which the sole or primary genetic alteration is in SMARCA4 or SMARCB1, two members of the SWI/SNF chromatin remodeling complex. In this review, we present a brief overview of the classical example of such tumors, ovarian small cell carcinoma of hypercalcemic type, and then a detailed review and update of SMARCB1‐deficient and SMARCA4‐deficient tumors of the uterus and vulva.

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