Successful Treatment of Metastatic Skin Lesions With Electrochemotherapy

Kubota, Yōko; Mir, Lluis M.; Nakada, Teruhiro; Sasagawa, Isoji; Suzuki, Hitoshi; Aoyama, Natsumi

doi:10.1016/s0022-5347(01)62559-x

Cited by 49 publications

(15 citation statements)

References 3 publications

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“…Electrochemotherapy has been proven effective as a palliative treatment for hemorrhagic and painful tumor nodules [124,125,140,162]. This is a secondary result of the 'vascular lock' phenomenon -explained earlier in this review.…”

Section: Clinical Applications Of Ect In the Treatment Of Melanomamentioning

confidence: 80%

“…This study showed that the results of the treatment were comparable among the institutions even though there were small differences in their treatment protocols and the route used for administering bleomycin. Additional studies using ECT with intratumoral bleomycin for metastatic melanoma lesions, even though they were limited to a small number of patients, showed OR rates of 71-100% (CR 23-100% and PR 0-62%) [124,[138][139][140]. Rols et al in 2000 published the results of four melanoma patients with 54 metastatic nodules treated with ECT and intravenous bleomycin, obtaining OR rates of 93% [141].…”

Section: Evolution Of Ect From In Vitro Studies To Clinical Practicementioning

confidence: 99%

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Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

Möller¹,

Salwa

Soden

et al. 2009

Expert Review of Anticancer Therapy

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Treatment of recurrent or in-transit unresectable melanoma continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a therapeutic option for those patients whose lesions are not suitable for surgical resection and who have exhausted all other treatment modalities. ECT combines electroporation of tumor cells with the administration either of intravenous or intratumoral antineoplastic drugs, such as bleomycin or cisplatin. The cell membranes are thus rendered permeant to these impermeant hydrophilic drugs with a several hundred-fold increase in intracellular delivery and cytotoxicity. ECT is an effective treatment in the palliative management of unresectable recurrent disease with overall objective response rates of approximately 80-90%. ECT technology continues to evolve allowing application to deeper lesions. By combining ECT with tumor-specific immunostimulating approaches, such as perilesional IL-2, CpG oligonucleotides or prior immunogene therapy, there is a promise of both local and systemic control of this disease.

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Section: Clinical Applications Of Ect In the Treatment Of Melanomamentioning

confidence: 80%

Section: Evolution Of Ect From In Vitro Studies To Clinical Practicementioning

confidence: 99%

Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

Möller¹,

Salwa

Soden

et al. 2009

Expert Review of Anticancer Therapy

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“…4,24,25 Nevertheless, any increase in the CIS or MMC cytotoxicity is appreciated because bladder cancer is already sensitive to these drugs. Our study shows that electrochemotherapy was effective using intratumor MMC or CIS.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Experiments on Electrochemotherapy for Bladder Cancer

et al. 2015

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“…Kubata et al also discuss a case of complete resolution in a patient treated with bleomycin electrochemotherapy. [9]. Although we need to consider that a non-operative clinical plan in these patients leads to certain disease progression, a single case in the literature describes a case of cutaneous metastasis with spontaneous regression [10].…”

Section: Discussionmentioning

confidence: 99%

Solitary skin metastasis from sarcomatoid carcinoma of the bladder: a case report

et al. 2011

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IntroductionCutaneous metastases from carcinomas of the bladder are very rare. They are related to advanced stages of the disease and have poor prognosis with low survival rates. The common treatment modality of cutaneous metastases from a primary bladder cancer is wide local excision followed by chemotherapy.Case presentationWe report a case of solitary skin metastasis from a rare type of urinary bladder carcinoma in a 68 year-old Caucasian man. Urinary bladder carcinoma metastasizing to the skin is an uncommon finding despite the high incidence of this tumor. Skin metastasis generally presents in the late stages of this disease and indicates a poor outcome.ConclusionsBecause of the extremely aggressive malignant potential of sarcomatoid carcinomas, the indications for a transurethral resection of the bladder should be carefully assessed and suitable therapeutic strategies should be examined further.

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Successful Treatment of Metastatic Skin Lesions With Electrochemotherapy

Cited by 49 publications

References 3 publications

Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

In Vitro and In Vivo Experiments on Electrochemotherapy for Bladder Cancer

Solitary skin metastasis from sarcomatoid carcinoma of the bladder: a case report

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