Successful Treatment of Naegleria fowleri Meningoencephalitis by Using Intravenous Amphotericin B, Fluconazole and Rifampicin

Vargas-Zepeda, Jesús; Gómez-Alcalá, Alejandro V.; Vázquez-Morales, José Alfonso; Licea-Amaya, Leonardo; Jonckheere, Johan F. De; Lares‐Villa, Fernando

doi:10.1016/j.arcmed.2004.11.003

Cited by 127 publications

(84 citation statements)

References 17 publications

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“…Naegleria fowleri infections are difficult to control and the mortality of patients is >95% because of rapid progression of disease, difficulty in diagnosis and lack of effective drugs [8]. There have been reports of cases successfully treated with amphotericin B, fluconazole, rifampicin and chloramphenicol [24,25]. Previously, other investigators have also reported the in vitro or in vivo effects of various antimicrobial, antiprotozoal, antiviral and antifungal agents against Naegleria spp.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri

Kim

Lee

Sohn

et al. 2008

International Journal of Antimicrobial Agents

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Section: Discussionmentioning

confidence: 99%

Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri

Kim

Lee

Sohn

et al. 2008

International Journal of Antimicrobial Agents

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“…Granulomas are surrounded by an infiltrate rich in lymphocytes and plasma cells. Multinucleated giant cells may be present inside and outside granulomas [34,59]. Diagnosis includes skin biopsy, staining, indirect immunofluorescence assays and culture methods.…”

Section: Eye Infections -Acanthamoeba Keratitis (Ak)mentioning

confidence: 99%

Human infections caused by free-living amoebae

Król-Turmińska¹,

Olender²

2017

Ann Agric Environ Med.

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Introduction. Among free-living amoebae that are widely distributed in nature only four genera/species are known as agents of human infections: Acanthamoeba spp., Naegleriafowleri, Balamuthia mandrillaris and Sappiniapedata. These amoebae are not well adapted to parasitism, and could exist in the human environment without the need for a host. Infections due to these amoebae, despite low morbidity, are characterized by relatively high mortality rate and pose serious clinical problems. Objectve. This review study presents and summarizes current knowledge about infections due to pathogenic and opportunistic free-living amoebae focused on epidemiology, clinical manifestations, diagnosis and treatment based on global literature. State of knowledge. All four genera have been recognized as etiologic factors of fatal central nervous system infections and other serious diseases in humans. N. fowleri causes an acute fulminating meningoencephalitis in children and young adults. Acanthamoeba spp. and B.mandrillaris are opportunistic pathogens causing granulomatous amoebic encephalitis and disseminated or localized infections which could affect the skin, sinuses, lungs, adrenals and/or bones. Acanthamoeba spp. is also the main agent of acute eye infection -Acanthamoeba keratitis, mostly in contact lens wearers. However, there is only one recognized case of encephalitis caused by S. pedata. Conclusions. Amoebic diseases are difficult to diagnose which leads to delayed treatment, and result in a high mortality rate. Considering those issues, there is an urgent need to draw more attention to this type of diseases.

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“…Estes organismos constituem um grupo de protozoários presentes no solo e em pequenos reservatórios de água fresca (12). Algumas espécies de amebas de vida livre podem comportar-se como parasitas facultativos em seres humanos e animais domésticos, sendo capazes de invadir o sistema nervoso central e outros tecidos (13,14).…”

Section: Introductionunclassified

AVALIAÇÃO DA CONTAMINAÇÃO PARASITOLÓGICA DE RÚCULAS (Eruca sativa) COMERCIALIZADAS EM ERECHIM, RS, BRASIL

Matiasso

Gonçalves

Grazziotin

2014

Infarma

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This study aimed to evaluate the presence of enteroparasites in arugula (Eruca sativa) commercialized in Erechim, RS. In the period from March to May 2013 were analyzed, through spontaneous sedimentation method, 40 samples, obtained from markets. Among the argulas analysed, 22.5 showed contamination with trophozoites and/or cysts of amoeba. Eggs or larvae of pathogenic helminths were not found in the analysed samples. Vegetables consumed without previous cooking can present standard of sanitary and hygienic quality inadequate, condition that emphasizes the need for greater guidance to producers and handlers, with regard to its correct handling and hygiene. Keywords: Eruca sativa; amoeba; intestinal parasites RESUMOEste estudo teve como objetivo avaliar a contaminação por enteroparasitas em amostras de rúcula (Eruca sativa) comercializadas na cidade de Erechim-RS. No período de março a maio de 2013, foram analisadas, pelo método de sedimentação espontânea, 40 amostras, obtidas em mercados e feiras do produtor. Dentre as rúculas analisadas, 22,5% apresentaram contaminação por trofozoítos e/ou cistos de ameba. Não foram encontrados ovos ou larvas de helmintos patogênicos ao homem. Vegetais consumidos sem cozimento prévio podem apresentar padrão de qualidade higiênico-sanitária inadequado, o que destaca a necessidade de maior orientação aos produtores e manipuladores, no que se refere à sua correta manipulação e higienização.Palavras Chave: Eruca sativa; amebas; parasitas intestinais

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Successful Treatment of Naegleria fowleri Meningoencephalitis by Using Intravenous Amphotericin B, Fluconazole and Rifampicin

Cited by 127 publications

References 17 publications

Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri

Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri

Human infections caused by free-living amoebae

AVALIAÇÃO DA CONTAMINAÇÃO PARASITOLÓGICA DE RÚCULAS (Eruca sativa) COMERCIALIZADAS EM ERECHIM, RS, BRASIL

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