Successful treatment of niclosamide- and praziquantel-resistant beef tapeworm infection with nitazoxanide

Lateef, Mohammad; Zargar, Showkat Ali; Khan, Abdul Rashid; Nazir, Muzzaffar; Shoukat, Abid

doi:10.1016/j.ijid.2007.04.017

Cited by 59 publications

(23 citation statements)

References 7 publications

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“…Niclosamide, albendazloe, nitazoxanide and praziquantel are the antihelminthic drugs available for the treatment of tapeworm infections. T. saginata infections resistant to niclosamide and praziqauntel but sensitive to nitazoxanide was reported by Lateef et al 4 The present case was not responding to repeated doses of albendazole and niclosamide but responded to a single dosage of praziquantel. Taeniasis due to T. saginata is rare in India except in certain communities who eat beef regularly.…”

Section: Discussionsupporting

confidence: 60%

A case of albendazole and niclosamide resistant Taenia saginata infection

et al. 2017

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Taenia saginata infection is an important food-borne parasitic zoonosis which is endemic in countries where majority of people eat raw or inadequately cooked beef. The infection is rare in India except in Jammu Kashmir and Northeast states, India. Majority of taeniasis patients are asymptomatic, few may present with a variety of abdominal symptoms and rarely hepatobiliary complications. Diagnosis is made commonly by finding proglottids and or eggs in the faeces. Here we report a chronic and uncomplicated case of saginata taeniasis resistant to niclosamide and albendazole but responded to a single dosage of praziquantel 15 mg per Kg body weight.

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Section: Discussionsupporting

confidence: 60%

A case of albendazole and niclosamide resistant Taenia saginata infection

et al. 2017

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“…The drug of choice for human Taenia infections is praziquantel although niclosamide is also recommended. While these drugs offer a highly effective treatment for the disease, reports of praziquantel-and niclosamide-resistant Taenia populations are emerging (Lateef et al 2008); hence the use of both drugs should be tightly regulated in the future. Early diagnosis of Taenia infection is crucial for the prevention of cysticercosis in humans and a number of coproantigen (Allan & Craig 2006) and serological tests (Garcia et al 2007) based on purified parasite antigens are now available.…”

Section: Zoonotic Cestode Infections (A) Cysticercosismentioning

confidence: 99%

Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases

Robinson

Dalton

2009

Phil. Trans. R. Soc. B

148

109

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Zoonotic infections are among the most common on earth and are responsible for .60 per cent of all human infectious diseases. Some of the most important and well-known human zoonoses are caused by worm or helminth parasites, including species of nematodes (trichinellosis), cestodes (cysticercosis, echinococcosis) and trematodes (schistosomiasis). However, along with social, epidemiological and environmental changes, together with improvements in our ability to diagnose helminth infections, several neglected parasite species are now fast-becoming recognized as important zoonotic diseases of humans, e.g. anasakiasis, several fish-borne trematodiasis and fasciolosis. In the present review, we discuss the current disease status of these primary helminth zoonotic infections with particular emphasis on their diagnosis and control. Advances in molecular biology, proteomics and the release of helminth genome-sequencing project data are revolutionizing parasitology research. The use of these powerful experimental approaches, and their potential benefits to helminth biology are also discussed in relation to the future control of helminth infections of animals and humans.

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“…Niclosamide (C13H8Cl2N2O4) is a small-molecule drug of the teniacide anthelmintic family that is effective against human tapeworms (14,15). This agent was previously reported to have therapeutic activities in several cancers by inhibition of STAT3 (14,16,17).…”

Section: Introductionmentioning

confidence: 99%

JAK2/STAT3 pathway as a therapeutic target in ovarian cancers

et al. 2018

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Abstract. The activation of JAK2/STAT3 pathway has been reported to have critical roles in several solid tumors. The present study aimed to evaluate the correlation between JAK2/STAT3 activation and clinicopathological parameters in ovarian cancer types. Tissue microarrays made from the patients treated at the National Defense Medical College Hospital between 1984 and 2008 were evaluated using immunohistochemical (IHC) stainings. Medical charts of these patients including IHC results were retrospectively analyzed, and prognostic factors for progression-free survival and overall survival were evaluated. Among 341 enrolled patients, positive expression of p-STAT3 was observed in 95 cases (28%). Positive p-STAT3 was an independent worse prognostic factor for overall survival in all the cases. Additionally, p-STAT3 expression was related with overall survival in patients with clear-cell histology, but not in serous histology. The effect of an inhibitor of STAT3, niclosamide, was evaluated in ovarian clear-cell cancer cells, and niclosamide treatment decreased expression of p-STAT3, leading to increased apoptosis in a dose-dependent manner in vitro. The activation of JAK2/STAT3 pathway had significant impact on survival of ovarian cancers, especially for the cases with clear-cell histology. Although further analyses are needed, suppression of this pathway could be a candidate for the treatment of ovarian cancers.

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Successful treatment of niclosamide- and praziquantel-resistant beef tapeworm infection with nitazoxanide

Abstract: Nitazoxanide is a safe, effective, inexpensive, and well-tolerated drug for the treatment of niclosamide- and praziquantel-resistant beef tapeworm infection.

Cited by 59 publications

References 7 publications

A case of albendazole and niclosamide resistant Taenia saginata infection

A case of albendazole and niclosamide resistant Taenia saginata infection

Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases

JAK2/STAT3 pathway as a therapeutic target in ovarian cancers

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