Successful treatment of pulmonary invasive fungal infection by <i>Penicillium</i> non<i>‐marneffei</i> in lymphoblastic lymphoma: case report and literature review

Ramírez, Isabel; Hidrón, Alicia; Cardona, Ricardo

doi:10.1002/ccr3.1527

Cited by 24 publications

(12 citation statements)

References 20 publications

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“… 16 Both P. citrinum and P. oxalicum have been previously reported as agents of invasive mycoses causing breakthrough infections in patients on voriconazole therapy. 17 , 18 In the present study, a 1–9 dilution step (2–18-fold) and a 2–12 dilution step (4–24-fold) decrease in in vitro activity of olorofim as compared with amphotericin B and systemic azoles, respectively, were observed, suggesting the novel antifungal to be a promising candidate in treatment of infections with Penicillium and Talaromyces species.…”

Section: Discussionsupporting

confidence: 55%

In vitroactivity of the novel antifungal olorofim against dermatophytes and opportunistic moulds includingPenicilliumandTalaromycesspecies

Singh

Meis

et al. 2021

Journal of Antimicrobial Chemotherapy

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Objectives Olorofim is a novel antifungal agent with in vitro activity against Aspergillus and other opportunistic moulds. We investigated the in vitro activity of olorofim against a range of filamentous fungi comprising isolates of Aspergillus species, Scedosporium species, Alternaria alternata, dermatophytes, including terbinafine- and multidrug-resistant Trichophyton species, and Penicillium/Talaromyces species originating from patients in North India. Methods Antifungal susceptibility of olorofim was tested against 241 mould isolates of Penicillium/Talaromyces species, Trichophyton species, A. fumigatus and cryptic Aspergillus species, Scedosporium species, and Alternaria alternata using CLSI broth microdilution. The comparators were five systemic azoles, amphotericin B, terbinafine, and luliconazole. Results Overall, olorofim showed highly potent in vitro activity against dermatophytes and opportunistic moulds (MIC range of 0.004–0.125 mg/L) except for Alternaria alternata. Penicillium, and Talaromyces species and Trichophyton species exhibited a low geometric mean (GM) MIC (GM 0.027 mg/L and 0.015 mg/L, respectively) of olorofim. Importantly, a 2–12 dilution step decrease in in vitro activity of olorofim as compared with azoles was observed against Penicillium and Talaromyces. Notably, olorofim displayed potent in vitro activity against Trichophyton isolates including terbinafine-resistant and azole-resistant Trichophyton mentagrophytes/interdigitale with a modal MIC value of 0.008 mg/L. Further, azole-resistant A. fumigatus isolates harbouring mutations in azole target Cyp51A genes and several cryptic aspergilli displayed low MICs (range 0.004–0.03 mg/L) of olorofim. However, no in vitro activity of olorofim against Alternaria alternata was observed. Conclusions The potent in vitro activity of olorofim against drug-resistant dermatophytes and opportunistic moulds is promising, warranting evaluation of the clinical utility of olorofim.

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Section: Discussionsupporting

confidence: 55%

In vitroactivity of the novel antifungal olorofim against dermatophytes and opportunistic moulds includingPenicilliumandTalaromycesspecies

Singh

Meis

et al. 2021

Journal of Antimicrobial Chemotherapy

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“…The most frequent isolates in our research were members of the genus Penicillium, which have already been described in several cases of invasive fungal infections, with pulmonary, pericardial, hepatosplenic involvement, and others (Geltner et al 2013; Ramírez et al 2018). Cladosporium spp.…”

Section: Discussionsupporting

confidence: 58%

Fungi in dialysis water and dialysate: occurrence, susceptibility to antifungal agents and biofilm production capacity

Anversa

Lara

Romani

et al. 2021

Journal of Water and Health

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The aim of this study was to investigate the occurrence of fungi in dialysis water and dialysate, in addition to evaluating the susceptibility to antifungals and the biofilm production capacity of isolated microorganisms. The samples were collected in three hemodialysis units in Bauru (Brazil), every 15 days (July 2017–June 2018) at post-reverse osmosis, reuse, and dialysate points. The fungi were isolated by spread plate on Sabouraud dextrose agar. Filamentous fungi were phenotypically identified and yeasts were subjected to molecular evaluation of the ITS region. Susceptibility test to antifungals was carried out by the broth microdilution method and biofilm production capacity was evaluated in microtiter plates using crystal violet staining. Fungi were isolated in 52/216 (24.1%) samples, with an average count of 16.3 (10–40) CFU/mL. Overall, 61 microorganisms were identified, with 54 (88.5%) filamentous fungi and 7 (11.5%) yeasts. The main genera included were Penicillium, Cladosporium, Scedosporium, Rhinocladiella, Fusarium, and Emmonsia. Most isolates showed high values of minimum inhibitory concentration for 5-flucytosine and fluconazole and 35/45 (77.8%) isolates were classified as strong producers of biofilm. In order to increase the safety of the dialysis process, the adoption of control measures and monitoring of fungi in hemodialysis fluids is suggested.

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“…In patients with hematologic malignancy, invasive fungal infection has an incidence rate as high as 25% and is an important cause of morbidity and mortality, with Aspergillus species representing the most frequently isolated microorganisms. Penicillium species (excluding Talaromyces species, such as T. marneffei, formerly known as P. marneffei ) are a rare but increasingly recognized opportunistic pathogen causing invasive fungal infections in this population, particularly in patients with acute leukemia who are marrow suppressed from intensive chemotherapy [ 5 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The majority of cases in this review were pulmonary [ 5 , 18–23 ], including 1 that also caused local extension with pericardial tamponade [ 18 ], and 4 cases were disseminated infection [ 24–27 ]. These cases demonstrate that exposure to Penicillium via inhalation in vulnerable hosts appears to be a common mechanism leading to pulmonary and disseminated infection.…”

Section: Discussionmentioning

confidence: 99%

First Reported Case of Invasive Cutaneous Penicillium cluniae Infection in a Patient With Acute Myelogenous Leukemia: A Case Report and Literature Review

Mehta

Hofacker

Villalba

et al. 2021

Open Forum Infectious Diseases

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Certain Penicillium species are emerging opportunistic pathogens. While these can be common causes of airborne contamination of clinical cultures, an increasing number of reports describe clinically significant disease in the immunocompromised population, particularly in patients with hematologic malignancy. The typical site of infection is respiratory but disseminated infection is also reported with some frequency. Therefore, culture growth of Penicillium in respiratory and other clinical samples from immunocompromised patients requires thorough investigation with clinical correlation. Here we report a case of angioinvasive Penicillium cluniae infection of the right shin in a patient with acute myeloid leukemia and review reported cases of invasive Penicillium infection (excluding Talaromyces marneffei) in hematologic malignancy patients to characterize the emerging pathogen in this vulnerable population.

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Successful treatment of pulmonary invasive fungal infection by Penicillium non‐marneffei in lymphoblastic lymphoma: case report and literature review

Cited by 24 publications

References 20 publications

In vitroactivity of the novel antifungal olorofim against dermatophytes and opportunistic moulds includingPenicilliumandTalaromycesspecies

In vitroactivity of the novel antifungal olorofim against dermatophytes and opportunistic moulds includingPenicilliumandTalaromycesspecies

Fungi in dialysis water and dialysate: occurrence, susceptibility to antifungal agents and biofilm production capacity

First Reported Case of Invasive Cutaneous Penicillium cluniae Infection in a Patient With Acute Myelogenous Leukemia: A Case Report and Literature Review

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