Successful Treatment of Refractory Angina Pectoris due to Multivessel Coronary Spasm with Valsartan

Sakamoto, Tomohiro; Shintomi, Yoshitaka; Yoshimura, Michihiro; Ogawa, Hisao

doi:10.2169/internalmedicine.46.0132

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…A renin-angiotensin system (RAS) inhibitor was used to prevent left ventricular remodeling caused by AMI in the present case. Indeed, adding an RAS inhibitor to antianginal drugs has been reported to control refractory CSA ( 8 ). RAS inhibitor may have some preventive effect against CSA.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Corticosteroid Treatment for Refractory Multivessel Vasospastic Coronary Angina with Hypereosinophilia

et al. 2018

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A 43-year-old man was diagnosed with acute myocardial infarction (AMI) due to multivessel coronary vasospasm. Accordingly, two coronary vasodilators were administered, and he was discharged without an angina attack. However, from the following day, he reported frequent chest pain and was re-hospitalized. Despite adding multiple coronary vasodilators, it was difficult to completely suppress the angina attack. He also demonstrated hypereosinophilia from the onset of AMI, and his eosinophil count gradually increased up to 6,238 /μL. After corticosteroid administration was started, the vasospasm was completely controlled, and his eosinophil count normalized. He remained free from angina attacks for two years with corticosteroid therapy.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Corticosteroid Treatment for Refractory Multivessel Vasospastic Coronary Angina with Hypereosinophilia

et al. 2018

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“…A drug-refractory case of VSA with multi vessel spasm was successfully treated with valsartan as an add-on drug (daily dose of 80 mg followed by 160 mg) associated with regular antianginal and antioxidative medications (maximum daily doses of isosorbide mononitrate (40 mg), diltiazem (200 mg), and tocopherol nicotinate (300 mg) 100) . The effect of valsartan was confirmed by the re-occurrence of the attacks with the same frequency after stopping valsartan.…”

Section: Oestrogen Replacement Therapy In Postmenopausal Womenmentioning

confidence: 99%