Successfully drug treatment for necrotizing fasciitis caused by Streptococcus pyogenes in 88‐year‐old patient

Abstract

Necrotizing fasciitis (NF) is a soft-tissue infection that is rare but rapidly progressive with incidence estimated to be 4.0 to 15.5 cases per 100,000 population. 1 NF is characterized by a progressive destruction of the muscle fascia and overlying subcutaneous fat. Due to a high risk of mortality, prompt diagnosis of signs and symptoms and treatment are essential to avoid an adverse patient care pathway including sepsis, amputation, and death. 2 Monomicrobial NF is most commonly associated with Gram-positive organisms such as group A Streptococcus. 1 Pyrogenic toxics produced by this germ can induced streptococcal toxic shock syndrome associated with worse prognosis particularly in elderly population. 3 In this report, we present a case of lower-extremity NF caused by Streptococcus pyogenes that was successfully treated without interval surgical intervention.

Ozone adjunct treatment in facing multidrug‐resistant bacteria?

“…A recent paper on this journal reported a successful anti‐septic treatment on a case of necrotizing fasciitis caused by Streptococcus pyogenes infection in an 88‐year‐old woman. 1 The patient suffered an S. faecalis infected scar for 15 days on the left tibia, making her unable to stand. The leg appeared inflamed and painful, with a 3 cm wound exhibiting a necrotic area on the left heel.…”

“…Antibiotic treatment consisted in amoxicillin 8 g/day on hospital Day 1 (without clavulanic acid) and clindamycin 1.2 g/day for 15 days. 1 Following this treatment, the patient did not fully ameliorate her wound aspect and stenosis, yet the wound was washed, treated with alginate‐based dressings and fibrin removed, then some improvement could be observed. The antibiotic treatment failed in reducing the bacterial inflammation.…”