Bleeding at the site cannulation in subclavian artery and pulmonary bleeding: case reportAn 18-year-old woman developed bleeding at the site of the subclavian artery and pulmonary bleeding during anticoagulant treatment with heparin for extracorporeal membrane oxygenation (ECMO).The pregnant woman was admitted to the hospital in Lithuania on 19 October 2012 at gestational weeks 27. She had a high fever, pain in her lower back and abdomen, headache, nausea and dizziness. The blood tests revealed elevated inflammatory markers. The specimen for blood culture was taken, and she started receiving empirical treatment with IV cefuroxime 750mg every 8h. An ultrasound of the fetus revealed breech presentation, with the amniotic fluid index normal. On admission day 2, she delivered a baby girl via C-section due to breech presentation. The neonate's birthweight was 1562g and an Apgar score was 7-8. An unpleasant smell and turbid excreta appeared straight after the separation of the placenta from the wall of the uterus. Surgery was finished without complications. However, the mother suddenly experienced significant tachycardia and specimen for blood culture was taken. After 45 minutes of surgery, she developed disseminated intravascular coagulation (DIC) leading to massive bleeding. It was concluded that sepsis provoked the DIC. Her antibacterial therapy was immediately changed from cefuroxime to vancomycin and meropenem. She was transferred to the ICU due to pulmonary oedema which had started four hours after the bleeding. She developed acute cardiopulmonary failure and septic shock, requiring intubation, mechanical ventilation and vasopressor support. Blood culture results were received and both were positive. Staphylococcus aureus was in the first culture, which had been taken after the woman's admission to hospital. Two different strains of Enterobacter cloacea were in the second culture, which had been taken during the C-section. As a result of uterine infection, she underwent a hysterectomy on the fourth day after the C-section resulting in slight recovery. On day 3 after the hysterectomy, her respiratory function deteriorated due to acute respiratory distress syndrome (ARDS). She developed permissive hypercapnia and haemodynamic instability requiring norepinephrine. Therefore, she was initiated on ECMO under heparin anticoagulation [dosage and route not stated]. As a result of heparin, she developed bleeding and haematoma at the site of the subclavian artery where the ECMO cannula was inserted [duration of treatment to reaction onset not stated]. Moreover, she had infection of haematoma and septicaemia with Enterobacter spp. was observed.The woman's antibacterial treatment was adjusted to imipenem and vancomycin. A thoracotomy was performed and the haematoma removed. The postoperative period was complicated with a severe pulmonary bleeding episode requiring several rethoracotomies. While maintaining hypocoagulation for the ECMO, pulmonary bleeding continued leading to a new haematoma. She again underwent a thoracotomy...