Succession Analysis of Gut Microbiota Structure of Participants from Long-Lived Families in Hechi, Guangxi, China

Abstract

The gut microbiota structure has been proposed to be involved in longevity. In this study, trajectories of age-related changes in gut microbiota were analyzed by comparing the gut microbiota composition from long-lived families. A specific bacterial community pattern and signature taxa of long-lived people were found in long-lived families, such as the enrichment of Enterobacteriaceae in all age groups and the higher abundances of Christensenellaceae, Verrucomicrobiaceae, Porphyromonadaceae, Rikenellaceae, Mogibacteriaceae, and Odoribacteraceae in long-lived elderly and the positive correlation between them. The cumulative abundance of the core microbiota was approximately stable along with age, but the genera and species in the core microbiota were rearranged with age, especially in Ruminococcaceae and Lachnospiraceae. Compared with the control group, the proportions of Lachnospiraceae, Roseburia, and Blautia were significantly higher in participants from the long-lived village, but their abundances gradually decreased along with age. Based on functional predictions, the proportions of pathways related to short-chain fatty acid metabolism, amino acid metabolism, and lipoic acid metabolism were significantly higher in the long-lived elderly compared with the offspring group. The trajectory of gut microbiota composition along with age in participants from long-lived families might reveal potential health-promoting metabolic characteristics, which could play an important role in healthy aging.

Arenga pinnata Resistant Starch Modulate Gut Microbiota and Ameliorate Intestinal Inflammation in Aged Mice

“…The methods used for fecal microbial genomic DNA extraction, library construction, sequencing, and bioinformatics analysis were the same as we previously described [ 5 ]. The analysis of α-diversity, which included the calculation of observed OTU numbers, Chao1, Shannon index, and Simpson index in all samples, was estimated by MOTHUR (v1.31.2) at the OTU level.…”

“…Aging is associated with changes in the gut microbiota that might result in dysbiosis and illnesses [ 4 ]. It is reported that specific beneficial bacteria, such as Bifidobacterium, are depleted in elderly individuals [ 4 ], and the abundance of Lactobacillus in the elderly from a long-lived village was higher than in controls [ 5 ]. Therefore, regulating the gut microbiota may provide an opportunity to improve health among the elderly [ 6 ].…”

The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps

“…Higher levels of Akkermansia are also found in healthy individuals' feces than in feces from individuals with inflammatory or metabolic diseases (70). The families to which ASVs associated with RSB are assigned, Verrucomicrobiaceae, Rikenellaceae, Ruminococcaceae, Lachnospiraceae, Christensenellaceae, and Mogibacteriaceae, were also enriched in long-lived families in a recent study (71). Additionally, the family Christensenellaceae consistently has been associated with reduced visceral fat mass and leanness (72), and Christenellaceae, Mogibacteriaceae, and Rikenellaceae were associated with leanness, longevity, healthy aging, and protective of cardiovascular and metabolic disorders (73,74).…”

Assessment of the safety and probiotic properties of Roseburia intestinalis: A potential “Next Generation Probiotic”

“…Administration of R. intestinalis increased the levels of certain beneficial gut bacteria. Porphyromonadaceae abundance increased in long-lived populations, and the proportion of R. intestinalis also increased ( Ren et al, 2021 ). The abundance of Barnesiella , Porphyromonadaceae , and Roseburia also increased after vitamin D1 administration in patients with Crohn’s disease ( Schäffler et al, 2018 ), indicating that these bacteria may function synergistically.…”