Sucrose Diester of Aryldihydronaphthalene-Type Lignan with Anti-inflammatory Activity from Heliotropium angiospermum

Santos, George Luís Dias dos; Araújo, Diego Igor Alves Fernandes de; Silva, Joanda Paolla Raimundo e; Nascimento, Yuri Mangueira do; Souza, Thalisson Amorim de; Opretzka, Luiza Carolina França; Villarreal, Cristiane Flora; Abreu, Lucas Silva; Santos, Fernando Martins dos; Melo, José Iranildo Miranda de; Fechine, Yvana; Tavares, Josean Fechine; Silva, Marcelo Sobral da

doi:10.1007/s43450-022-00295-1

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It possesses mainly neuroprotective, anti-acetyl cholinesterase and hepatoprotective properties, and is rapidly eliminated from human and rat blood circulation after per os administration, metabolized predominantly to caffeic, coumaric and ferulic acids. According to the results of previous phytochemical studies, RA is considered as a chemotaxonomic marker among Boraginaceae taxa [ 11 , 12 , 13 , 14 ], while it has been also isolated from H. foertherianum [ 30 ] and H. angiospermum [ 31 ], together with ethyl lithosprmate in the latter.…”

Section: Discussionmentioning

confidence: 99%

Heliotropium procubens Mill: Taxonomic Significance and Characterization of Phenolic Compounds via UHPLC–HRMS- In Vitro Antioxidant and Enzyme Inhibitory Activities

et al. 2023

View full text Add to dashboard Cite

The aim of the present study was the phytochemical analysis of the aerial parts of Heliotropium procumbens Mill., a herb from Boraginaceae plant family not previously studied. The methanol (ME) and aqueous extracts (WE) of the aerial parts were assayed for their total phenolic and flavonoid content and antioxidant properties, using free radical scavenging (DPPH, ABTS), reducing power (FRAP, CUPRAC), phosphomolybdenum and metal chelating assays. The extracts displayed considerable free radical scavenging activity against DPPH and ABTS radicals, with potential values of 46.88 and 68.31 mg TE/g extract for ME, and 93.43 and 131.48 mg TE/g extract for WE, respectively. Key clinical enzymes involved in neurodegenerative diseases AChE and BChE, diabetes (α-amylase and α-glucosidase) and skin whitening (tyrosinase) were also assayed. The phytochemical profile of the studied species was determined through UHPLC–HRMS, whereby 26 secondary metabolites were identified, three of which (luteolin-7-glucoside, lithospermic and rosmarinic acids) were isolated and structurally determined by NMR spectral means. H. procubens was found to harbor bioactive metabolites and could, hence, serve as a source of biological activities which could be further explored and exploited for potential applications.

show abstract