Sucrose polyester does not inhibit gastric acid secretion or stimulate cholecystokinin release in men

Maas, M.I.M.; Hopman, W. P. M.; Wijk, Thea van der; Katan, Martijn B.; Jansen, J. B. M. J.

doi:10.1093/ajcn/65.3.761

Cited by 15 publications

(5 citation statements)

References 56 publications

(53 reference statements)

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“…Thus, substitution of chips made with olestra for chips cooked with conventional oils reduced the occurrence of postprandial gastro‐oesophageal reflux. These results are consistent with a lower production of serum CCK after the olestra meal, 30 because CCK is implicated in reducing lower oesophageal sphincter pressure.…”

Section: Structure and Function Of The Gastrointestinal Tractsupporting

confidence: 85%

Review article: olestra and its gastrointestinal safety

Thomson

Hunt

Zorich

1998

Aliment Pharmacol Ther

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Olestra is a fat substitute made from sucrose and vegetable oil. Olestra is neither digested nor absorbed, and therefore adds no calories or fat to the diet. Because the gut is the only organ that is exposed to olestra, the potential for olestra to affect gastrointestinal structure and function, and the absorption of nutrients from the gut, has been investigated. Histological evaluations performed after long-term feeding studies have shown no indications that olestra causes injury to the gastrointestinal mucosa. Olestra is not metabolized by the colonic microflora, and has no meaningful effects on the metabolic function of these organisms. Studies of gastrointestinal transit have shown that the consumption of olestra with food does not affect gastric emptying, or small or large bowel transit times. Olestra does not affect the absorption of macronutrients, water-soluble vitamins or minerals. It causes a dose-responsive decrease in the availability of the fat-soluble vitamins A, D, E and K; however, this potentially adverse effect is offset by the addition of vitamins to olestra-containing foods. Olestra has no consistent effect on the amount of total bile acids excreted in the faeces, and therefore probably has no significant effect on bile acid absorption. The occurrence of gastrointestinal symptoms, including diarrhoea, loose stools, gas and abdominal cramping, after consumption of olestra under ordinary snacking conditions is comparable to that following consumption of triglyceride-containing snacks.

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Section: Structure and Function Of The Gastrointestinal Tractsupporting

confidence: 85%

Review article: olestra and its gastrointestinal safety

Thomson

Hunt

Zorich

1998

Aliment Pharmacol Ther

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“…It has been suggested that CCK acts as a satiety agent for fat in humans, based on the observation that a blocker of the CCK receptor inhibits the satiating effect of intestinal fat [45]. Fat substitutes, however, do not release CCK [46], which may explain why satiety decreases.…”

Section: Satiety Signalsmentioning

confidence: 99%

The global obesity epidemic: Snacking and obesity may start with free meals during infant feeding

Erlanson–Albertsson¹,

Zetterström²

2005

Acta Paediatrica

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“…We believe that with a shorter time interval the volume and weight effects rather than the energy content and macronutrient effects of the preload will be measured on appetite and energy intake. Another argument in favour of a 90 min time interval is that the digestion of regular amounts of carbohydrates and fats results in the largest differences after 60 ± 90 min in appetite-related physiological responses, such as CCK (Maas et al, 1997), insulin (Jenkins et al, 1987), glucose (Wolever et al, 1991;Jenkins et al, 1987) and diet-induced thermogenesis (Blundell et al, 1993;Visser et al, 1995).…”

Section: Designmentioning

confidence: 99%

Short-term regulation of food intake in children, young adults and the elderly

et al. 2000

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Objective: The present study investigated the effects of consuming preloads with different macronutrient and energy contents on subsequent intake and subjective feelings of hunger and satiety in children, young adults and the elderly. Subjects: 30 Children (4 ± 6 y), 33 young adults (18 ± 26 y) and 24 elderly (61 ± 86 y). Design: A`preload test meal' design was applied. Subjects were given four different strawberry yoghurt preloads that varied in energy and macronutrient content, or no yoghurt. Children, young adults and elderly consumed 200, 340 and 300 g of the preload, respectively. One yoghurt was low-fat, low-carbohydrate and low in energy (the control; 0.7 MJa500 g serving), one yoghurt was high-fat and medium in energy (71% of energy (en%) of fat; 2 MJa500 g serving), one yoghurt was high-carbohydrate and medium in energy (87 en% of carbohydrate; 2 MJa500 g serving) and the fourth yoghurt was high-fat and high-carbohydrate and high in energy (42 en% of fat and 53 en% of carbohydrate; 3 MJa500 g serving). Ninety minutes after preload consumption, subjects had an attractive ad libitum lunch-buffet. Energy intake at lunch and subjective feelings of hunger and satiety were analysed. Results: The ability to compensate at lunch did not differ among the three age groups. Compared to the nopreload condition, all children, young adults and elderly ate signi®cantly less after the high-fat and highcarbohydrate yoghurt. The energy compensation observed in the children ranged between 7 21% and 34%, in the young adults between 15% and 44% and in the elderly between 17% and 23%. Hunger responses were clearly different between young adults and the elderly. Compared to the no-preload condition, the young adults showed larger differences in their appetite ratings than the elderly, indicating that the elderly were less sensitive to the energy content of the preload than the young adults. Conclusion: We conclude that the ability to regulate the food intake within a preload 90 min test meal paradigm did not differ among children, young adults and the elderly. Sponsorship: This study was funded by the European Commission as part of project FAIR-CT95-0574.

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Sucrose polyester does not inhibit gastric acid secretion or stimulate cholecystokinin release in men

Cited by 15 publications

References 56 publications

Review article: olestra and its gastrointestinal safety

Review article: olestra and its gastrointestinal safety

The global obesity epidemic: Snacking and obesity may start with free meals during infant feeding

Short-term regulation of food intake in children, young adults and the elderly

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