Sudden Caffeine Withdrawal Triggers Migraine—A Randomized Controlled Trial

Alstadhaug, Karl Bjørnar; Ofte, Hilde Karen; Müller, Kai Ivar; Andreou, Anna P.

doi:10.3389/fneur.2020.01002

Cited by 19 publications

(17 citation statements)

References 37 publications

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“…Tabel 1 menunjukkan rangkuman kajian kesepuluh penelitian tersebut. Literatur yang memiliki sampel terbanyak ialah penelitian Booth et al 12 dan yang paling sedikit ialah penelitian Alstadhaug et al 13 Dari 10 penelitian yang dikaji, didapatkan hubungan antara kafein dan migrain, Pada hampir semua penelitian terlihat bahwa kafein dapat menyebabkan migrain baik setelah kafein dikonsumsi (kelompok nonabsen) maupun saat kafein sedang tidak dikonsumsi (kelompok absen). Tabel 2 memperlihatkan bahwa sembilan dari 10 penelitian menunjukkan adanya hubungan antara kafein dan migrain.…”

Section: Hasil Penelitianunclassified

“…Pada penelitian ini didapatkan hanya tiga literatur yang membahas kelompok absen. Sekitar 53% dari total jumlah subjek penelitian Alstadhaug et al 13 mengalami migrain sementara hanya 33% dari total jumlah sampel penelitian Lee et al 17 yang mengalami migrain pada kelompok absen. Terdapat dua literatur yang memiliki data kedua kelompok tersebut.…”

Section: Hasil Penelitianunclassified

“…Terdapat dua literatur yang memiliki data kedua kelompok tersebut. Yang pertama ialah penelitian Alstadhaug et al 13 yang semua sampelnya mengalami migrain dan dibagi atas dua kelompok, yaitu kelompok absen (53%) dan kelompok nonabsen (47%). Yang kedua ialah penelitian Lee et al 17 yang semua sampelnya juga mengalami migrain dengan sekitar 66,7% dari total jumlah sampelnya ialah kelompok nonabsen.…”

Section: Hasil Penelitianunclassified

“…7,8 Gejala putus kafein atau caffeine withdrawal symptoms umum terjadi pada individu yang sudah mengalami adaptasi toleransi karena mengonsumsi kafein secara kronis sehingga ketidakhadiran kafein dalam tubuh dapat memunculkan gejala seperti migrain. 8,9 Penelitian Alstadhaug et al 13 yang meneliti 17 subjek yang sudah mengalami migrain dan mengonsumsi kafein ≥300 mg sampai ≤800 mg setiap hari selama minimal satu bulan, menemukan bahwa terdapat subjek yang meneruskan konsumsi kafeinnya dan ada yang menghentikan. Terdapat perbedaan bermakna antara perbandingan proporsi subjek yang mengalami migrain saat plasebo dan subjek yang mengonsumsi kafein.…”

Section: Bahasanunclassified

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Hubungan antara Migrain dan Kafein

Kumaat

Pertiwi²,

Mawuntu³

2021

eCL

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Migraine is one of the primary headaches that often causes moderate to severe disability. One of the most commonly consumed psychoactive substances associated with migraine is caffeine. This study was aimed to evaluate the relationship between migraine and caffeine thoroughly based on various studies. This was a literature review study using databases of Pubmed/Medline, Cochrane, Wiley Online Library, Science Direct, Google Scholar, and Garuda. The eligibility criteria for this study were observational research articles or clinical trials, written in Indonesian or English, published in the last five years, and their fulltexts could be accessed. The results obtained 10 articles. Almost all of them showed that caffeine could cause migraine whether after caffeine consumption (non-absent group) or no consumption of caffeine (absent group). The association of caffeine with migraine was more significant than with tension headaches. Besides being a trigger factor of migraine, caffeine cpuld also act as a migraine therapy. In conclusion, there is a close association between migraine and caffeine. Migraine tends to be triggered than to be reduced by caffeine.Keywords: caffeine, migraine Abstrak: Migrain merupakan salah satu jenis nyeri kepala primer yang sering menyebabkan disabilitas sedang dan berat. Salah satu zat psikoaktif yang umum dikonsumsi dan berhubungan dengan migrain yaitu kafein. Penelitian ini bertujuan untuk menelaah hubungan migrain dan kafein lebih mendalam berdasarkan berbagai penelitian. Jenis penelitian ialah literature review menggunakan database dari Pubmed/Medline, Cochrane, Wiley Online Library, Science Direct, Google Scholar, dan Garuda. Kriteria kelayakan artikel penelitian ialah artikel penelitian observasional atau uji klinis, ditulis dalam Bahasa Indonesia atau Inggris, terbit dalam lima tahun terakhir, dan naskah lengkap artikel dapat diakses secara lengkap. Hasil penelitian mendapatkan 10 artikel penelitian. Hampir semua penelitian memperlihatkan bahwa kafein dapat menyebabkan migrain baik setelah kafein dikonsumsi (kelompok nonabsen) maupun saat kafein sudah tidak dikonsumsi (kelompok absen). Hubungan kafein dengan migrain lebih kuat dibandingkan dengan nyeri kepala tipe tegang. Selain menjadi factor pencetus, kafein juga dapat berperan sebagai terapi migrain. Simpulan penelitian ini ialah terdapat hubungan erat antara migrain dan kafein. Migrain cenderung lebih sering dicetuskan oleh kafein dibandingkan diringankan oleh kafein.Kata kunci: kafein, migrain

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Section: Hasil Penelitianunclassified

Section: Bahasanunclassified

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Hubungan antara Migrain dan Kafein

Kumaat

Pertiwi²,

Mawuntu³

2021

eCL

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“…Fasting is a well-known migraine trigger (7), with many hypotheses on the reasons for this (8). Important factors that are associated with fasting during Ramadan are sudden caffeine withdrawal, a possible migraine trigger (9) and sleep pattern, which may also result in these headaches (7). The objective of this study is to understand the impact of fasting of the month of Ramadan on migraines.…”

Section: Introductionmentioning

confidence: 99%

Impact of Ramadan Fasting on Migraine Headache

Al-Hashel

Abokalawa

Toma

et al. 2021

Preprint

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Background: Fasting is known as a migraine trigger for migraine. Muslims fast one month every luminal year. We aimed to study the impact of The Holy month of Ramadan on episodic migraine.Methods: This retrospective study included patients diagnosed as migraine according to The International Classification of Headache Disorders, 3rd edition (ICDH-3). Both genders, aged between 18 and 65 years were included. The impact of fasting and changing habits during the month of Ramadan was studied. Frequency, severity of migraine attacks and number of analgesic days during Ramadan were compared to those during Shaban, the Immediate previous month to Ramadan. Number of breaking fasting due to migraine was reported.Results: This study identified 293 with migraine with mean age and mean disease duration 37.09 ±9.36, 12.34±9.27 years respectively. Most of them were females(89.1%). During Ramadan month, the patient had significant increase in migraine days 10.42±7.98 compared with 6.90±6.55 migraine days during the previous month (p < 0.001). Also, days of analgesic use (11.32±10.46 versus 6.11±6.69;P<0,001) and migraine severity (7.46±2.39 versus 6.84±2.25; P<0,001) were significantly increased during Ramadan compared to Shaban. Most of the patients completed fasting the whole month of Ramadan. A minority (1.7) could not tolerate fasting whole Ramadan due intolerable migraine headache and 36.5% broke their fasting for some days during Ramadan. Some patients changed previous prophylactic therapy before fasting to reduce the impact of fasting on migraine headache. Most of our cohort (82.3%) continue on the same management plan for migraine during Ramadan. Majority of cohort (75.4%) reported that migraine interfered with their daily activities due to fasting during Ramadan. Conclusion: Ramadan fasting has negative impact on the majority of migraine patients. Physicians should educate migraine patients who to manage their headache and habits before starting fasting.

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Pharmacokinetics and Safety of the Nucleoside Analog Antiviral Drug Galidesivir Administered to Healthy Adult Subjects

Mathis

Collins

Dobo

et al. 2022

Clinical Pharm in Drug Dev

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Galidesivir (BCX4430) is an adenosine nucleoside analog broadly active in cell culture against multiple RNA virus families, and active in animal models of viral diseases associated with Ebola, Marburg, yellow fever, Zika, and Rift Valley fever. Current studies demonstrated the pharmacokinetics and safety of the first‐in‐human evaluations of galidesivir as intramuscular (IM) and intravenous (IV) formulations. Two double‐blind, placebo‐controlled, dose‐ranging studies were conducted enrolling 126 healthy subjects. Study 1 evaluated the safety and tolerability of IM galidesivir over single day dosing, single day dosing ± lidocaine, and 7‐day dosing with lidocaine. Study 2 evaluated the safety and tolerability of single ascending doses of IV galidesivir. Safety and tolerability were evaluated via clinical and laboratory monitoring. The plasma concentration–time profile of galidesivir at doses 0.3 to 10 mg/kg IM was characterized by rapid absorption, an initial rapid distribution and clearance phase, and an extended terminal elimination phase. The initial rapid distribution and extended terminal elimination were mimicked in the profile of galidesivir at doses 5 to 20 mg/kg IV. No fatal events or related serious adverse events were reported. No clinically significant dose‐related trends in laboratory values, vital signs, electrocardiograms, or echocardiograms were noted. Galidesivir was safe and generally well tolerated.

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Sudden Caffeine Withdrawal Triggers Migraine—A Randomized Controlled Trial

Cited by 19 publications

References 37 publications

Hubungan antara Migrain dan Kafein

Hubungan antara Migrain dan Kafein

Impact of Ramadan Fasting on Migraine Headache

Pharmacokinetics and Safety of the Nucleoside Analog Antiviral Drug Galidesivir Administered to Healthy Adult Subjects

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